5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
- Autores
- Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; Martinetti Montanari, Jorge Anibal
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- 5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.
Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Couto, Veronica Muniz. Universidade Estadual de Campinas; Brasil
Fil: de Paula, Eneida. Universidade Estadual de Campinas; Brasil
Fil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina - Materia
-
Ultradeformable liposomes
Skin- therapy
5-Fluorouracil
Antineoplastic drug - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/86630
Ver los metadatos del registro completo
id |
CONICETDig_d35fe1b0711495b7f82bd6f6e61c4ae6 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/86630 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapyCalienni, Maria NataliaPrieto, Maria JimenaCouto, Veronica Munizde Paula, EneidaAlonso, Silvia del ValleMartinetti Montanari, Jorge AnibalUltradeformable liposomesSkin- therapy5-FluorouracilAntineoplastic drughttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/25-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Couto, Veronica Muniz. Universidade Estadual de Campinas; BrasilFil: de Paula, Eneida. Universidade Estadual de Campinas; BrasilFil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; ArgentinaAmerican Institute of Physics Inc.2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86630Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-80094-243XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1063/1.5047778info:eu-repo/semantics/altIdentifier/url/https://aip.scitation.org/doi/abs/10.1063/1.5047778info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:02Zoai:ri.conicet.gov.ar:11336/86630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:02.778CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
title |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
spellingShingle |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy Calienni, Maria Natalia Ultradeformable liposomes Skin- therapy 5-Fluorouracil Antineoplastic drug |
title_short |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
title_full |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
title_fullStr |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
title_full_unstemmed |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
title_sort |
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy |
dc.creator.none.fl_str_mv |
Calienni, Maria Natalia Prieto, Maria Jimena Couto, Veronica Muniz de Paula, Eneida Alonso, Silvia del Valle Martinetti Montanari, Jorge Anibal |
author |
Calienni, Maria Natalia |
author_facet |
Calienni, Maria Natalia Prieto, Maria Jimena Couto, Veronica Muniz de Paula, Eneida Alonso, Silvia del Valle Martinetti Montanari, Jorge Anibal |
author_role |
author |
author2 |
Prieto, Maria Jimena Couto, Veronica Muniz de Paula, Eneida Alonso, Silvia del Valle Martinetti Montanari, Jorge Anibal |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ultradeformable liposomes Skin- therapy 5-Fluorouracil Antineoplastic drug |
topic |
Ultradeformable liposomes Skin- therapy 5-Fluorouracil Antineoplastic drug |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation. Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Couto, Veronica Muniz. Universidade Estadual de Campinas; Brasil Fil: de Paula, Eneida. Universidade Estadual de Campinas; Brasil Fil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina |
description |
5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/86630 Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-8 0094-243X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/86630 |
identifier_str_mv |
Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-8 0094-243X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1063/1.5047778 info:eu-repo/semantics/altIdentifier/url/https://aip.scitation.org/doi/abs/10.1063/1.5047778 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Institute of Physics Inc. |
publisher.none.fl_str_mv |
American Institute of Physics Inc. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842268640916799488 |
score |
13.13397 |