5-Fluorouracil-loaded ultradeformable liposomes for skin therapy

Autores
Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; Martinetti Montanari, Jorge Anibal
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.
Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Couto, Veronica Muniz. Universidade Estadual de Campinas; Brasil
Fil: de Paula, Eneida. Universidade Estadual de Campinas; Brasil
Fil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina
Materia
Ultradeformable liposomes
Skin- therapy
5-Fluorouracil
Antineoplastic drug
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86630
Acceder
id CONICETDig_d35fe1b0711495b7f82bd6f6e61c4ae6
oai_identifier_str oai:ri.conicet.gov.ar:11336/86630
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 5-Fluorouracil-loaded ultradeformable liposomes for skin therapyCalienni, Maria NataliaPrieto, Maria JimenaCouto, Veronica Munizde Paula, EneidaAlonso, Silvia del ValleMartinetti Montanari, Jorge AnibalUltradeformable liposomesSkin- therapy5-FluorouracilAntineoplastic drughttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/25-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Couto, Veronica Muniz. Universidade Estadual de Campinas; BrasilFil: de Paula, Eneida. Universidade Estadual de Campinas; BrasilFil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; ArgentinaAmerican Institute of Physics Inc.2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86630Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-80094-243XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1063/1.5047778info:eu-repo/semantics/altIdentifier/url/https://aip.scitation.org/doi/abs/10.1063/1.5047778info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:38Zoai:ri.conicet.gov.ar:11336/86630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:38.799CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
title 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
spellingShingle 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
Calienni, Maria Natalia
Ultradeformable liposomes
Skin- therapy
5-Fluorouracil
Antineoplastic drug
title_short 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
title_full 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
title_fullStr 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
title_full_unstemmed 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
title_sort 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
dc.creator.none.fl_str_mv Calienni, Maria Natalia
Prieto, Maria Jimena
Couto, Veronica Muniz
de Paula, Eneida
Alonso, Silvia del Valle
Martinetti Montanari, Jorge Anibal
author Calienni, Maria Natalia
author_facet Calienni, Maria Natalia
Prieto, Maria Jimena
Couto, Veronica Muniz
de Paula, Eneida
Alonso, Silvia del Valle
Martinetti Montanari, Jorge Anibal
author_role author
author2 Prieto, Maria Jimena
Couto, Veronica Muniz
de Paula, Eneida
Alonso, Silvia del Valle
Martinetti Montanari, Jorge Anibal
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ultradeformable liposomes
Skin- therapy
5-Fluorouracil
Antineoplastic drug
topic Ultradeformable liposomes
Skin- therapy
5-Fluorouracil
Antineoplastic drug
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv 5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.
Fil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Couto, Veronica Muniz. Universidade Estadual de Campinas; Brasil
Fil: de Paula, Eneida. Universidade Estadual de Campinas; Brasil
Fil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina
description 5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the horny layer). In this work we propose the incorporation of 5FU into ultradeformable liposomes as a drug delivery system able to cross the intact skin barrier and transport the active to the viable epidermis. Thus, the drug could reach deep skin lesions in earlier stages of the disease. We present some biophysical parameters of a stable formulation and its toxic effects on zebrafish model (Danio rerio). In addition, we followed two co-encapsulated fluorescent probes along to the stratum corneum and viable epidermis of the human skin to determine the penetration profiles of both lipophilic and hydrophilic compounds in this kind of formulation.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86630
Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-8
0094-243X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86630
identifier_str_mv Calienni, Maria Natalia; Prieto, Maria Jimena; Couto, Veronica Muniz; de Paula, Eneida; Alonso, Silvia del Valle; et al.; 5-Fluorouracil-loaded ultradeformable liposomes for skin therapy; American Institute of Physics Inc.; AIP Conference Proceedings; 1990; 1; 7-2018; 1-8
0094-243X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1063/1.5047778
info:eu-repo/semantics/altIdentifier/url/https://aip.scitation.org/doi/abs/10.1063/1.5047778
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Institute of Physics Inc.
publisher.none.fl_str_mv American Institute of Physics Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613035080024064
score 13.069144

Publicaciones similares