Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status

Autores
Kamariski, Mariana; Biscardi, Mónica; Cestino, Laura; Miatello, Roberto; Guntche Enrique; Garramuño, Patricia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim: To study whether adiponectin and resistin serum concentrations in children on peritoneal dialysis (PD) were related to insulin resistance (IR) and anthropometric parameters of nutritional status, 11 PD patients, 9 chronic kidney disease (CKD) patients and 10 healthy children were studied. Methods: Glucose and insulin were measured during the oral glucose tolerance test. Levels of adiponectin and resistin were evaluated by ELISA, insulin by RIA. Results: In CKD patients, higher homeostasis model assessment-insulin resistance (HOMA-IR), fasting and 2-hour serum insulin levels were shown compared to control and to PD patients. Body mass index (BMI) and body fat content were severely decreased while serum adiponectin levels were significantly higher in PD patients relative to controls. No differences among groups were shown in resistin levels. On regression modeling, inverse independent associations were observed between adiponectin with percentile BMI, weight and height z-score, and with body fat content. In contrast, no relationship was found between adiponectin and IR parameters. In multiple regression analysis, adiponectin was negatively correlated with BMI. A negative association of adiponectin and resistin with glomerular filtration rate was also shown. Conclusion: A role for adiponectin in terms of its association with clinical wasting parameters in PD pediatric patients might be suggested.
Fil: Kamariski, Mariana. Hospital Pediátricos H. Notti, Mendoza, Argentina; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Biscardi, Mónica. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Cestino, Laura. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Miatello, Roberto. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Guntche Enrique. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Garramuño, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
Adiponectin, Children
Chronic Kidney Disease
Continuous Ambulatory Peritoneal Dialysis
Insulin Resistance
Nutritional Status
Oral Glucose Tolerance Testing
Peritoneal Dialysis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79659
Acceder
id CONICETDig_d25ab30224cde3f737b4afd36ced793d
oai_identifier_str oai:ri.conicet.gov.ar:11336/79659
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional statusKamariski, MarianaBiscardi, MónicaCestino, LauraMiatello, RobertoGuntche EnriqueGarramuño, PatriciaAdiponectin, ChildrenChronic Kidney DiseaseContinuous Ambulatory Peritoneal DialysisInsulin ResistanceNutritional StatusOral Glucose Tolerance TestingPeritoneal Dialysishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Aim: To study whether adiponectin and resistin serum concentrations in children on peritoneal dialysis (PD) were related to insulin resistance (IR) and anthropometric parameters of nutritional status, 11 PD patients, 9 chronic kidney disease (CKD) patients and 10 healthy children were studied. Methods: Glucose and insulin were measured during the oral glucose tolerance test. Levels of adiponectin and resistin were evaluated by ELISA, insulin by RIA. Results: In CKD patients, higher homeostasis model assessment-insulin resistance (HOMA-IR), fasting and 2-hour serum insulin levels were shown compared to control and to PD patients. Body mass index (BMI) and body fat content were severely decreased while serum adiponectin levels were significantly higher in PD patients relative to controls. No differences among groups were shown in resistin levels. On regression modeling, inverse independent associations were observed between adiponectin with percentile BMI, weight and height z-score, and with body fat content. In contrast, no relationship was found between adiponectin and IR parameters. In multiple regression analysis, adiponectin was negatively correlated with BMI. A negative association of adiponectin and resistin with glomerular filtration rate was also shown. Conclusion: A role for adiponectin in terms of its association with clinical wasting parameters in PD pediatric patients might be suggested.Fil: Kamariski, Mariana. Hospital Pediátricos H. Notti, Mendoza, Argentina; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Biscardi, Mónica. Hospital Pediátrico H. Notti, Mendoza, Argentina; ArgentinaFil: Cestino, Laura. Hospital Pediátrico H. Notti, Mendoza, Argentina; ArgentinaFil: Miatello, Roberto. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Guntche Enrique. Hospital Pediátrico H. Notti, Mendoza, Argentina; ArgentinaFil: Garramuño, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaKarger2009-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79659Kamariski, Mariana; Biscardi, Mónica; Cestino, Laura; Miatello, Roberto; Guntche Enrique; et al.; Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status; Karger; Nephron Clinical Practice; 113; 1; 8-2009; c24-c321660-2110CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/228072info:eu-repo/semantics/altIdentifier/doi/10.1159/000228072info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:36Zoai:ri.conicet.gov.ar:11336/79659instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:36.55CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
title Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
spellingShingle Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
Kamariski, Mariana
Adiponectin, Children
Chronic Kidney Disease
Continuous Ambulatory Peritoneal Dialysis
Insulin Resistance
Nutritional Status
Oral Glucose Tolerance Testing
Peritoneal Dialysis
title_short Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
title_full Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
title_fullStr Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
title_full_unstemmed Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
title_sort Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status
dc.creator.none.fl_str_mv Kamariski, Mariana
Biscardi, Mónica
Cestino, Laura
Miatello, Roberto
Guntche Enrique
Garramuño, Patricia
author Kamariski, Mariana
author_facet Kamariski, Mariana
Biscardi, Mónica
Cestino, Laura
Miatello, Roberto
Guntche Enrique
Garramuño, Patricia
author_role author
author2 Biscardi, Mónica
Cestino, Laura
Miatello, Roberto
Guntche Enrique
Garramuño, Patricia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adiponectin, Children
Chronic Kidney Disease
Continuous Ambulatory Peritoneal Dialysis
Insulin Resistance
Nutritional Status
Oral Glucose Tolerance Testing
Peritoneal Dialysis
topic Adiponectin, Children
Chronic Kidney Disease
Continuous Ambulatory Peritoneal Dialysis
Insulin Resistance
Nutritional Status
Oral Glucose Tolerance Testing
Peritoneal Dialysis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aim: To study whether adiponectin and resistin serum concentrations in children on peritoneal dialysis (PD) were related to insulin resistance (IR) and anthropometric parameters of nutritional status, 11 PD patients, 9 chronic kidney disease (CKD) patients and 10 healthy children were studied. Methods: Glucose and insulin were measured during the oral glucose tolerance test. Levels of adiponectin and resistin were evaluated by ELISA, insulin by RIA. Results: In CKD patients, higher homeostasis model assessment-insulin resistance (HOMA-IR), fasting and 2-hour serum insulin levels were shown compared to control and to PD patients. Body mass index (BMI) and body fat content were severely decreased while serum adiponectin levels were significantly higher in PD patients relative to controls. No differences among groups were shown in resistin levels. On regression modeling, inverse independent associations were observed between adiponectin with percentile BMI, weight and height z-score, and with body fat content. In contrast, no relationship was found between adiponectin and IR parameters. In multiple regression analysis, adiponectin was negatively correlated with BMI. A negative association of adiponectin and resistin with glomerular filtration rate was also shown. Conclusion: A role for adiponectin in terms of its association with clinical wasting parameters in PD pediatric patients might be suggested.
Fil: Kamariski, Mariana. Hospital Pediátricos H. Notti, Mendoza, Argentina; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Biscardi, Mónica. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Cestino, Laura. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Miatello, Roberto. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Guntche Enrique. Hospital Pediátrico H. Notti, Mendoza, Argentina; Argentina
Fil: Garramuño, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Aim: To study whether adiponectin and resistin serum concentrations in children on peritoneal dialysis (PD) were related to insulin resistance (IR) and anthropometric parameters of nutritional status, 11 PD patients, 9 chronic kidney disease (CKD) patients and 10 healthy children were studied. Methods: Glucose and insulin were measured during the oral glucose tolerance test. Levels of adiponectin and resistin were evaluated by ELISA, insulin by RIA. Results: In CKD patients, higher homeostasis model assessment-insulin resistance (HOMA-IR), fasting and 2-hour serum insulin levels were shown compared to control and to PD patients. Body mass index (BMI) and body fat content were severely decreased while serum adiponectin levels were significantly higher in PD patients relative to controls. No differences among groups were shown in resistin levels. On regression modeling, inverse independent associations were observed between adiponectin with percentile BMI, weight and height z-score, and with body fat content. In contrast, no relationship was found between adiponectin and IR parameters. In multiple regression analysis, adiponectin was negatively correlated with BMI. A negative association of adiponectin and resistin with glomerular filtration rate was also shown. Conclusion: A role for adiponectin in terms of its association with clinical wasting parameters in PD pediatric patients might be suggested.
publishDate 2009
dc.date.none.fl_str_mv 2009-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79659
Kamariski, Mariana; Biscardi, Mónica; Cestino, Laura; Miatello, Roberto; Guntche Enrique; et al.; Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status; Karger; Nephron Clinical Practice; 113; 1; 8-2009; c24-c32
1660-2110
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79659
identifier_str_mv Kamariski, Mariana; Biscardi, Mónica; Cestino, Laura; Miatello, Roberto; Guntche Enrique; et al.; Adiponectin in children on peritoneal dialysis: Relationship to insulin resistance and nutritional status; Karger; Nephron Clinical Practice; 113; 1; 8-2009; c24-c32
1660-2110
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/228072
info:eu-repo/semantics/altIdentifier/doi/10.1159/000228072
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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