Markers of bone matebolism during 14 days of bed rest in young and older men

Autores
Buehlmeier, J.; Frings Meuthen, P.; Mohorko, N.; Lau, P.; Mazzucco, S.; Ferretti, Jose Luis; Biolo, G.; Pisot, R.; Simunic, B.; Rittweger, J.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and toassess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwentbed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented proteinand potassium bicarbonate afterwards. Biochemical markers of bone and calcium/phosphate metabolism were assessed.Results: At baseline urinary NTX and CTX were greater in younger than in older subjects (P<0.001), but increased duringBR (P<0.001) by a similar amount (P>0.17). P1NP was greater in young than in older subjects (P<0.001) and decreasedduring BR in the Young (P<0.001). Sclerostin increased during BR across groups (P=0.016). No systematic effects ofthe countermeasure were observed. Conclusion: In men, older age did not affect control of bone metabolism, but boneturnover was reduced. During BR formation markers were reduced only in younger men whereas resorption markersincreased to a comparable extent. Thus, we assume that older men are not at an elevated, and possibly even at a reducedrisk to lose bone when immobilized.
Fil: Buehlmeier, J.. Institute of Aerospace Medicine; Alemania. Universitat Bonn; Alemania
Fil: Frings Meuthen, P.. Institute of Aerospace Medicine; Alemania
Fil: Mohorko, N.. University of Primorska; Eslovenia
Fil: Lau, P.. Institute of Aerospace Medicine; Alemania
Fil: Mazzucco, S.. University Trieste; Italia
Fil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Biolo, G.. University Trieste; Italia
Fil: Pisot, R.. University of Primorska; Eslovenia
Fil: Simunic, B.. University of Primorska; Eslovenia
Fil: Rittweger, J.. Institute of Aerospace Medicine; Alemania
Materia
MECHANO ADAPTATION
AGE EFFECTS
IMMOBILIZATION
WNT SIGNALLING
COUNTERMEASURE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72328
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/72328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Markers of bone matebolism during 14 days of bed rest in young and older menBuehlmeier, J.Frings Meuthen, P.Mohorko, N.Lau, P.Mazzucco, S.Ferretti, Jose LuisBiolo, G.Pisot, R.Simunic, B.Rittweger, J.MECHANO ADAPTATIONAGE EFFECTSIMMOBILIZATIONWNT SIGNALLINGCOUNTERMEASUREhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and toassess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwentbed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented proteinand potassium bicarbonate afterwards. Biochemical markers of bone and calcium/phosphate metabolism were assessed.Results: At baseline urinary NTX and CTX were greater in younger than in older subjects (P<0.001), but increased duringBR (P<0.001) by a similar amount (P>0.17). P1NP was greater in young than in older subjects (P<0.001) and decreasedduring BR in the Young (P<0.001). Sclerostin increased during BR across groups (P=0.016). No systematic effects ofthe countermeasure were observed. Conclusion: In men, older age did not affect control of bone metabolism, but boneturnover was reduced. During BR formation markers were reduced only in younger men whereas resorption markersincreased to a comparable extent. Thus, we assume that older men are not at an elevated, and possibly even at a reducedrisk to lose bone when immobilized.Fil: Buehlmeier, J.. Institute of Aerospace Medicine; Alemania. Universitat Bonn; AlemaniaFil: Frings Meuthen, P.. Institute of Aerospace Medicine; AlemaniaFil: Mohorko, N.. University of Primorska; EsloveniaFil: Lau, P.. Institute of Aerospace Medicine; AlemaniaFil: Mazzucco, S.. University Trieste; ItaliaFil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Biolo, G.. University Trieste; ItaliaFil: Pisot, R.. University of Primorska; EsloveniaFil: Simunic, B.. University of Primorska; EsloveniaFil: Rittweger, J.. Institute of Aerospace Medicine; AlemaniaISMNI2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72328Buehlmeier, J.; Frings Meuthen, P.; Mohorko, N.; Lau, P.; Mazzucco, S.; et al.; Markers of bone matebolism during 14 days of bed rest in young and older men; ISMNI; Journal of Musculoskeletal and neuronal interaction; 17; 1; 1-2017; 399-4081108-71611108-7161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383768/info:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/pdf/67/jmni_17_399.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:22Zoai:ri.conicet.gov.ar:11336/72328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:22.691CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Markers of bone matebolism during 14 days of bed rest in young and older men
title Markers of bone matebolism during 14 days of bed rest in young and older men
spellingShingle Markers of bone matebolism during 14 days of bed rest in young and older men
Buehlmeier, J.
MECHANO ADAPTATION
AGE EFFECTS
IMMOBILIZATION
WNT SIGNALLING
COUNTERMEASURE
title_short Markers of bone matebolism during 14 days of bed rest in young and older men
title_full Markers of bone matebolism during 14 days of bed rest in young and older men
title_fullStr Markers of bone matebolism during 14 days of bed rest in young and older men
title_full_unstemmed Markers of bone matebolism during 14 days of bed rest in young and older men
title_sort Markers of bone matebolism during 14 days of bed rest in young and older men
dc.creator.none.fl_str_mv Buehlmeier, J.
Frings Meuthen, P.
Mohorko, N.
Lau, P.
Mazzucco, S.
Ferretti, Jose Luis
Biolo, G.
Pisot, R.
Simunic, B.
Rittweger, J.
author Buehlmeier, J.
author_facet Buehlmeier, J.
Frings Meuthen, P.
Mohorko, N.
Lau, P.
Mazzucco, S.
Ferretti, Jose Luis
Biolo, G.
Pisot, R.
Simunic, B.
Rittweger, J.
author_role author
author2 Frings Meuthen, P.
Mohorko, N.
Lau, P.
Mazzucco, S.
Ferretti, Jose Luis
Biolo, G.
Pisot, R.
Simunic, B.
Rittweger, J.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MECHANO ADAPTATION
AGE EFFECTS
IMMOBILIZATION
WNT SIGNALLING
COUNTERMEASURE
topic MECHANO ADAPTATION
AGE EFFECTS
IMMOBILIZATION
WNT SIGNALLING
COUNTERMEASURE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and toassess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwentbed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented proteinand potassium bicarbonate afterwards. Biochemical markers of bone and calcium/phosphate metabolism were assessed.Results: At baseline urinary NTX and CTX were greater in younger than in older subjects (P<0.001), but increased duringBR (P<0.001) by a similar amount (P>0.17). P1NP was greater in young than in older subjects (P<0.001) and decreasedduring BR in the Young (P<0.001). Sclerostin increased during BR across groups (P=0.016). No systematic effects ofthe countermeasure were observed. Conclusion: In men, older age did not affect control of bone metabolism, but boneturnover was reduced. During BR formation markers were reduced only in younger men whereas resorption markersincreased to a comparable extent. Thus, we assume that older men are not at an elevated, and possibly even at a reducedrisk to lose bone when immobilized.
Fil: Buehlmeier, J.. Institute of Aerospace Medicine; Alemania. Universitat Bonn; Alemania
Fil: Frings Meuthen, P.. Institute of Aerospace Medicine; Alemania
Fil: Mohorko, N.. University of Primorska; Eslovenia
Fil: Lau, P.. Institute of Aerospace Medicine; Alemania
Fil: Mazzucco, S.. University Trieste; Italia
Fil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Biolo, G.. University Trieste; Italia
Fil: Pisot, R.. University of Primorska; Eslovenia
Fil: Simunic, B.. University of Primorska; Eslovenia
Fil: Rittweger, J.. Institute of Aerospace Medicine; Alemania
description Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and toassess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwentbed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented proteinand potassium bicarbonate afterwards. Biochemical markers of bone and calcium/phosphate metabolism were assessed.Results: At baseline urinary NTX and CTX were greater in younger than in older subjects (P<0.001), but increased duringBR (P<0.001) by a similar amount (P>0.17). P1NP was greater in young than in older subjects (P<0.001) and decreasedduring BR in the Young (P<0.001). Sclerostin increased during BR across groups (P=0.016). No systematic effects ofthe countermeasure were observed. Conclusion: In men, older age did not affect control of bone metabolism, but boneturnover was reduced. During BR formation markers were reduced only in younger men whereas resorption markersincreased to a comparable extent. Thus, we assume that older men are not at an elevated, and possibly even at a reducedrisk to lose bone when immobilized.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72328
Buehlmeier, J.; Frings Meuthen, P.; Mohorko, N.; Lau, P.; Mazzucco, S.; et al.; Markers of bone matebolism during 14 days of bed rest in young and older men; ISMNI; Journal of Musculoskeletal and neuronal interaction; 17; 1; 1-2017; 399-408
1108-7161
1108-7161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72328
identifier_str_mv Buehlmeier, J.; Frings Meuthen, P.; Mohorko, N.; Lau, P.; Mazzucco, S.; et al.; Markers of bone matebolism during 14 days of bed rest in young and older men; ISMNI; Journal of Musculoskeletal and neuronal interaction; 17; 1; 1-2017; 399-408
1108-7161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383768/
info:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/pdf/67/jmni_17_399.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ISMNI
publisher.none.fl_str_mv ISMNI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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