A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection

Autores
Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.
Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina
Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina
Materia
Hiv
Antiretroviral Drugs
Optimal Control
Nonlinear Dynamics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26151
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A Closed-Loop Approach to Antiretroviral Therapies for HIV InfectionCostanza, VicenteRivadeneira Paz, Pablo SantiagoBiafore, Federico LeonardoD'attellis, Carlos EnriqueHivAntiretroviral DrugsOptimal ControlNonlinear Dynamicshttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; ArgentinaFil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; ArgentinaElsevier2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26151Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-1481746-8094CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2009.02.005info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809409000147info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:15Zoai:ri.conicet.gov.ar:11336/26151instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:15.632CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
title A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
spellingShingle A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
Costanza, Vicente
Hiv
Antiretroviral Drugs
Optimal Control
Nonlinear Dynamics
title_short A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
title_full A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
title_fullStr A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
title_full_unstemmed A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
title_sort A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
dc.creator.none.fl_str_mv Costanza, Vicente
Rivadeneira Paz, Pablo Santiago
Biafore, Federico Leonardo
D'attellis, Carlos Enrique
author Costanza, Vicente
author_facet Costanza, Vicente
Rivadeneira Paz, Pablo Santiago
Biafore, Federico Leonardo
D'attellis, Carlos Enrique
author_role author
author2 Rivadeneira Paz, Pablo Santiago
Biafore, Federico Leonardo
D'attellis, Carlos Enrique
author2_role author
author
author
dc.subject.none.fl_str_mv Hiv
Antiretroviral Drugs
Optimal Control
Nonlinear Dynamics
topic Hiv
Antiretroviral Drugs
Optimal Control
Nonlinear Dynamics
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.
Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina
Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina
description Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26151
Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-148
1746-8094
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26151
identifier_str_mv Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-148
1746-8094
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2009.02.005
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809409000147
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082620351315968
score 13.22299

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