A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
- Autores
- Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.
Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina
Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina - Materia
-
Hiv
Antiretroviral Drugs
Optimal Control
Nonlinear Dynamics - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/26151
Ver los metadatos del registro completo
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A Closed-Loop Approach to Antiretroviral Therapies for HIV InfectionCostanza, VicenteRivadeneira Paz, Pablo SantiagoBiafore, Federico LeonardoD'attellis, Carlos EnriqueHivAntiretroviral DrugsOptimal ControlNonlinear Dynamicshttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; ArgentinaFil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; ArgentinaElsevier2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26151Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-1481746-8094CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2009.02.005info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809409000147info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:03Zoai:ri.conicet.gov.ar:11336/26151instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:03.471CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
title |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
spellingShingle |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection Costanza, Vicente Hiv Antiretroviral Drugs Optimal Control Nonlinear Dynamics |
title_short |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
title_full |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
title_fullStr |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
title_full_unstemmed |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
title_sort |
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection |
dc.creator.none.fl_str_mv |
Costanza, Vicente Rivadeneira Paz, Pablo Santiago Biafore, Federico Leonardo D'attellis, Carlos Enrique |
author |
Costanza, Vicente |
author_facet |
Costanza, Vicente Rivadeneira Paz, Pablo Santiago Biafore, Federico Leonardo D'attellis, Carlos Enrique |
author_role |
author |
author2 |
Rivadeneira Paz, Pablo Santiago Biafore, Federico Leonardo D'attellis, Carlos Enrique |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Hiv Antiretroviral Drugs Optimal Control Nonlinear Dynamics |
topic |
Hiv Antiretroviral Drugs Optimal Control Nonlinear Dynamics |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.4 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies. Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina |
description |
Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/26151 Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-148 1746-8094 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/26151 |
identifier_str_mv |
Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-148 1746-8094 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2009.02.005 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809409000147 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613051404255232 |
score |
13.070432 |