Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance

Autores
Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.
Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil
Fil: Berbert, Luiz R.. Fundación Oswaldo Cruz; Brasil
Fil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
Materia
CHAGAS DISEASE
CORTISOL
DEHYDROEPIANDROSTERONE
THYMUS
TRYPANOSOMA CRUZI INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/195203
Acceder
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spelling Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalancePerez, Ana RosaMorrot, AlexandreBerbert, Luiz R.Terra Granado, EugeniaSavino, WilsonCHAGAS DISEASECORTISOLDEHYDROEPIANDROSTERONETHYMUSTRYPANOSOMA CRUZI INFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; BrasilFil: Berbert, Luiz R.. Fundación Oswaldo Cruz; BrasilFil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; BrasilFil: Savino, Wilson. Fundación Oswaldo Cruz; BrasilBlackwell Publishing2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195203Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-360077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06627.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06627.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:13Zoai:ri.conicet.gov.ar:11336/195203instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:13.56CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
title Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
spellingShingle Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
Perez, Ana Rosa
CHAGAS DISEASE
CORTISOL
DEHYDROEPIANDROSTERONE
THYMUS
TRYPANOSOMA CRUZI INFECTION
title_short Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
title_full Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
title_fullStr Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
title_full_unstemmed Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
title_sort Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
dc.creator.none.fl_str_mv Perez, Ana Rosa
Morrot, Alexandre
Berbert, Luiz R.
Terra Granado, Eugenia
Savino, Wilson
author Perez, Ana Rosa
author_facet Perez, Ana Rosa
Morrot, Alexandre
Berbert, Luiz R.
Terra Granado, Eugenia
Savino, Wilson
author_role author
author2 Morrot, Alexandre
Berbert, Luiz R.
Terra Granado, Eugenia
Savino, Wilson
author2_role author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
CORTISOL
DEHYDROEPIANDROSTERONE
THYMUS
TRYPANOSOMA CRUZI INFECTION
topic CHAGAS DISEASE
CORTISOL
DEHYDROEPIANDROSTERONE
THYMUS
TRYPANOSOMA CRUZI INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.
Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil
Fil: Berbert, Luiz R.. Fundación Oswaldo Cruz; Brasil
Fil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
description Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/195203
Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-36
0077-8923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/195203
identifier_str_mv Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-36
0077-8923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06627.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06627.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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