Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance
- Autores
- Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.
Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil
Fil: Berbert, Luiz R.. Fundación Oswaldo Cruz; Brasil
Fil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil - Materia
-
CHAGAS DISEASE
CORTISOL
DEHYDROEPIANDROSTERONE
THYMUS
TRYPANOSOMA CRUZI INFECTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/195203
Ver los metadatos del registro completo
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Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalancePerez, Ana RosaMorrot, AlexandreBerbert, Luiz R.Terra Granado, EugeniaSavino, WilsonCHAGAS DISEASECORTISOLDEHYDROEPIANDROSTERONETHYMUSTRYPANOSOMA CRUZI INFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations.Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; BrasilFil: Berbert, Luiz R.. Fundación Oswaldo Cruz; BrasilFil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; BrasilFil: Savino, Wilson. Fundación Oswaldo Cruz; BrasilBlackwell Publishing2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195203Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-360077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06627.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06627.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:34Zoai:ri.conicet.gov.ar:11336/195203instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:34.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
title |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
spellingShingle |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance Perez, Ana Rosa CHAGAS DISEASE CORTISOL DEHYDROEPIANDROSTERONE THYMUS TRYPANOSOMA CRUZI INFECTION |
title_short |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
title_full |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
title_fullStr |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
title_full_unstemmed |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
title_sort |
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance |
dc.creator.none.fl_str_mv |
Perez, Ana Rosa Morrot, Alexandre Berbert, Luiz R. Terra Granado, Eugenia Savino, Wilson |
author |
Perez, Ana Rosa |
author_facet |
Perez, Ana Rosa Morrot, Alexandre Berbert, Luiz R. Terra Granado, Eugenia Savino, Wilson |
author_role |
author |
author2 |
Morrot, Alexandre Berbert, Luiz R. Terra Granado, Eugenia Savino, Wilson |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CHAGAS DISEASE CORTISOL DEHYDROEPIANDROSTERONE THYMUS TRYPANOSOMA CRUZI INFECTION |
topic |
CHAGAS DISEASE CORTISOL DEHYDROEPIANDROSTERONE THYMUS TRYPANOSOMA CRUZI INFECTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations. Fil: Perez, Ana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil Fil: Berbert, Luiz R.. Fundación Oswaldo Cruz; Brasil Fil: Terra Granado, Eugenia. Fundación Oswaldo Cruz; Brasil Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil |
description |
Double positive CD4+CD8+ (DP) T cells normally represent a thymic subpopulation that is developed in the thymus as precursors of CD4+ or CD8+ single-positive T cells. Recent evidence showed that DP cells could be also tracked in secondary lymph organs showing an activated phenotype. The detection of DP activated population in the periphery that bears T cell receptors unselected during the thymic negative selection of either murine models of Trypanosoma cruzi infection and similar findings in human with Chagas disease raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and their possible links with immunoendocrine alterations. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/195203 Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-36 0077-8923 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/195203 |
identifier_str_mv |
Perez, Ana Rosa; Morrot, Alexandre; Berbert, Luiz R.; Terra Granado, Eugenia; Savino, Wilson; Extrathymic CD4+CD8+ lymphocytes in Chagas disease: Possible relationship with an immunoendocrine imbalance; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 4-2012; 27-36 0077-8923 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06627.x info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06627.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Blackwell Publishing |
publisher.none.fl_str_mv |
Blackwell Publishing |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613453874987008 |
score |
13.070432 |