Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae)
- Autores
- Vera Candioti, Josefina; Soloneski, Sonia Maria Elsa; Larramendy, Marcelo Luis
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow1 (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow1 increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22?66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22? 66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow1 (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus.
Fil: Vera Candioti, Josefina. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Soloneski, Sonia Maria Elsa. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Larramendy, Marcelo Luis. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina - Materia
-
Patton Flow
Erythrocyte
Erythroblast Ratio
Micronucleus
Mortality
Poeciliidae - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/19171
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Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae)Vera Candioti, JosefinaSoloneski, Sonia Maria ElsaLarramendy, Marcelo LuisPatton FlowErythrocyteErythroblast RatioMicronucleusMortalityPoeciliidaehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow1 (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow1 increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22?66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22? 66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow1 (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus.Fil: Vera Candioti, Josefina. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Soloneski, Sonia Maria Elsa. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Larramendy, Marcelo Luis. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaSage Publications Ltd2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19171Vera Candioti, Josefina; Soloneski, Sonia Maria Elsa; Larramendy, Marcelo Luis; Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae); Sage Publications Ltd; Toxicology And Industrial Health; 31; 11; 3-2015; 1051-10600748-2337CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/0748233713486958info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0748233713486958info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:21Zoai:ri.conicet.gov.ar:11336/19171instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:21.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
title |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
spellingShingle |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) Vera Candioti, Josefina Patton Flow Erythrocyte Erythroblast Ratio Micronucleus Mortality Poeciliidae |
title_short |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
title_full |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
title_fullStr |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
title_full_unstemmed |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
title_sort |
Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) |
dc.creator.none.fl_str_mv |
Vera Candioti, Josefina Soloneski, Sonia Maria Elsa Larramendy, Marcelo Luis |
author |
Vera Candioti, Josefina |
author_facet |
Vera Candioti, Josefina Soloneski, Sonia Maria Elsa Larramendy, Marcelo Luis |
author_role |
author |
author2 |
Soloneski, Sonia Maria Elsa Larramendy, Marcelo Luis |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Patton Flow Erythrocyte Erythroblast Ratio Micronucleus Mortality Poeciliidae |
topic |
Patton Flow Erythrocyte Erythroblast Ratio Micronucleus Mortality Poeciliidae |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow1 (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow1 increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22?66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22? 66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow1 (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus. Fil: Vera Candioti, Josefina. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Soloneski, Sonia Maria Elsa. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Larramendy, Marcelo Luis. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Laboratorio de Citogenetica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina |
description |
We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow1 (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow1 increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22?66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22? 66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow1 (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/19171 Vera Candioti, Josefina; Soloneski, Sonia Maria Elsa; Larramendy, Marcelo Luis; Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae); Sage Publications Ltd; Toxicology And Industrial Health; 31; 11; 3-2015; 1051-1060 0748-2337 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/19171 |
identifier_str_mv |
Vera Candioti, Josefina; Soloneski, Sonia Maria Elsa; Larramendy, Marcelo Luis; Pirimicarb-based formulation-induced genotoxicity and cytotoxicity on the fresh water fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae); Sage Publications Ltd; Toxicology And Industrial Health; 31; 11; 3-2015; 1051-1060 0748-2337 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1177/0748233713486958 info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0748233713486958 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sage Publications Ltd |
publisher.none.fl_str_mv |
Sage Publications Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268725339750400 |
score |
13.13397 |