Autophagy and pancreas disease

Autores
Vaccaro, Maria Ines
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Autophagy is an evolutionarily preserved degradation process of cytoplasm cellular constituents, which has been known for its roles in protecting cells against stresses such as starvation and in eliminating defective cellular constituents including sub-cellular structures. It is essentially a form of self-cannibalism hence the name that means, “self-eating” in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin H. et al in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.
Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ACUTE PANCREATITIS
AUTOPHAGY
CELL DEATH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161984
Acceder
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spelling Autophagy and pancreas diseaseVaccaro, Maria InesACUTE PANCREATITISAUTOPHAGYCELL DEATHhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Autophagy is an evolutionarily preserved degradation process of cytoplasm cellular constituents, which has been known for its roles in protecting cells against stresses such as starvation and in eliminating defective cellular constituents including sub-cellular structures. It is essentially a form of self-cannibalism hence the name that means, “self-eating” in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin H. et al in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaKarger2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161984Vaccaro, Maria Ines; Autophagy and pancreas disease; Karger; Pancreatology; 8; 4-5; 12-2008; 425-4291424-3903CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Pdf/151480info:eu-repo/semantics/altIdentifier/doi/10.1159/000151480info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:02:34Zoai:ri.conicet.gov.ar:11336/161984instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:02:34.879CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autophagy and pancreas disease
title Autophagy and pancreas disease
spellingShingle Autophagy and pancreas disease
Vaccaro, Maria Ines
ACUTE PANCREATITIS
AUTOPHAGY
CELL DEATH
title_short Autophagy and pancreas disease
title_full Autophagy and pancreas disease
title_fullStr Autophagy and pancreas disease
title_full_unstemmed Autophagy and pancreas disease
title_sort Autophagy and pancreas disease
dc.creator.none.fl_str_mv Vaccaro, Maria Ines
author Vaccaro, Maria Ines
author_facet Vaccaro, Maria Ines
author_role author
dc.subject.none.fl_str_mv ACUTE PANCREATITIS
AUTOPHAGY
CELL DEATH
topic ACUTE PANCREATITIS
AUTOPHAGY
CELL DEATH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Autophagy is an evolutionarily preserved degradation process of cytoplasm cellular constituents, which has been known for its roles in protecting cells against stresses such as starvation and in eliminating defective cellular constituents including sub-cellular structures. It is essentially a form of self-cannibalism hence the name that means, “self-eating” in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin H. et al in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.
Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Autophagy is an evolutionarily preserved degradation process of cytoplasm cellular constituents, which has been known for its roles in protecting cells against stresses such as starvation and in eliminating defective cellular constituents including sub-cellular structures. It is essentially a form of self-cannibalism hence the name that means, “self-eating” in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin H. et al in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161984
Vaccaro, Maria Ines; Autophagy and pancreas disease; Karger; Pancreatology; 8; 4-5; 12-2008; 425-429
1424-3903
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161984
identifier_str_mv Vaccaro, Maria Ines; Autophagy and pancreas disease; Karger; Pancreatology; 8; 4-5; 12-2008; 425-429
1424-3903
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Pdf/151480
info:eu-repo/semantics/altIdentifier/doi/10.1159/000151480
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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