Organochlorine levels in adipose tissue of women from a littoral region of Argentina

Autores
Muñoz de Toro, Monica Milagros; Beldomenico, Horacio Ramon; García, Silvia R.; Stoker, Cora; De Jesús, Juan J.; Beldomenico, Pablo Martín; Ramos, Jorge Guillermo; Luque, Enrique Hugo
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls (PCBs), are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogen-like effects. Northeastern Argentina, near the Paraná River, is characterized by intensive farming and agricultural activities and industrial development, and is therefore prone to high incidences of environmental and dietary exposure to OCCs. Hence, we conducted a study to (1) estimate the organochlorine residues present in mammary fat tissue in a population of women from this littoral region and (2) identify potential sources of exposure to OCCs. Our subjects were 76 women (residing in and around Santa Fe city and not occupationally exposed to organochlorines) who underwent excision biopsy of a breast lesion or had plastic surgery. Both frequency of occurrence and levels of organochlorine residues were high in breast adipose tissue of all the participants. The organochlorine residues most frequently found were p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) in all the subjects analyzed, hexachlorobenzene (HCB) in 86.8%, and β-hexachlorocyclohexane (β-HCH) in 75.0%. The incidence of PCB congeners was very low. p,p′-DDE and β-HCH residues reached the highest levels, 4794 and 1780 ppb, respectively. The diet was a relevant source of exposure, consumption of animal fat and freshwater fish playing a significant role. Bioaccumulation was evidenced by the significant positive association between organochlorine levels and body mass index (p = 0.0 0 0 3) and the age of the patient (p = 0.0 0 0 2). The frequency and levels of OCCs found in our study population raise concerns regarding Argentinean exposure to these endocrine disruptors.
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Beldomenico, Horacio Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: García, Silvia R.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Stoker, Cora. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: De Jesús, Juan J.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Beldomenico, Pablo Martín. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Ramos, Jorge Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina
Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina
Materia
BREAST TISSUE
DIET EXPOSURE
ENDOCRINE DISRUPTORS
ENVIRONMENTAL CONTAMINATION
PESTICIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99797
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99797
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Organochlorine levels in adipose tissue of women from a littoral region of ArgentinaMuñoz de Toro, Monica MilagrosBeldomenico, Horacio RamonGarcía, Silvia R.Stoker, CoraDe Jesús, Juan J.Beldomenico, Pablo MartínRamos, Jorge GuillermoLuque, Enrique HugoBREAST TISSUEDIET EXPOSUREENDOCRINE DISRUPTORSENVIRONMENTAL CONTAMINATIONPESTICIDEShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls (PCBs), are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogen-like effects. Northeastern Argentina, near the Paraná River, is characterized by intensive farming and agricultural activities and industrial development, and is therefore prone to high incidences of environmental and dietary exposure to OCCs. Hence, we conducted a study to (1) estimate the organochlorine residues present in mammary fat tissue in a population of women from this littoral region and (2) identify potential sources of exposure to OCCs. Our subjects were 76 women (residing in and around Santa Fe city and not occupationally exposed to organochlorines) who underwent excision biopsy of a breast lesion or had plastic surgery. Both frequency of occurrence and levels of organochlorine residues were high in breast adipose tissue of all the participants. The organochlorine residues most frequently found were p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) in all the subjects analyzed, hexachlorobenzene (HCB) in 86.8%, and β-hexachlorocyclohexane (β-HCH) in 75.0%. The incidence of PCB congeners was very low. p,p′-DDE and β-HCH residues reached the highest levels, 4794 and 1780 ppb, respectively. The diet was a relevant source of exposure, consumption of animal fat and freshwater fish playing a significant role. Bioaccumulation was evidenced by the significant positive association between organochlorine levels and body mass index (p = 0.0 0 0 3) and the age of the patient (p = 0.0 0 0 2). The frequency and levels of OCCs found in our study population raise concerns regarding Argentinean exposure to these endocrine disruptors.Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Beldomenico, Horacio Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: García, Silvia R.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Stoker, Cora. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: De Jesús, Juan J.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Beldomenico, Pablo Martín. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Ramos, Jorge Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; ArgentinaFil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; ArgentinaAcademic Press Inc Elsevier Science2006-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99797Muñoz de Toro, Monica Milagros; Beldomenico, Horacio Ramon; García, Silvia R.; Stoker, Cora; De Jesús, Juan J.; et al.; Organochlorine levels in adipose tissue of women from a littoral region of Argentina; Academic Press Inc Elsevier Science; Environmental Research; 102; 1; 9-2006; 107-1120013-9351CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2005.12.017info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0013935105002069info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:33:46Zoai:ri.conicet.gov.ar:11336/99797instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:33:46.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Organochlorine levels in adipose tissue of women from a littoral region of Argentina
title Organochlorine levels in adipose tissue of women from a littoral region of Argentina
spellingShingle Organochlorine levels in adipose tissue of women from a littoral region of Argentina
Muñoz de Toro, Monica Milagros
BREAST TISSUE
DIET EXPOSURE
ENDOCRINE DISRUPTORS
ENVIRONMENTAL CONTAMINATION
PESTICIDES
title_short Organochlorine levels in adipose tissue of women from a littoral region of Argentina
title_full Organochlorine levels in adipose tissue of women from a littoral region of Argentina
title_fullStr Organochlorine levels in adipose tissue of women from a littoral region of Argentina
title_full_unstemmed Organochlorine levels in adipose tissue of women from a littoral region of Argentina
title_sort Organochlorine levels in adipose tissue of women from a littoral region of Argentina
dc.creator.none.fl_str_mv Muñoz de Toro, Monica Milagros
Beldomenico, Horacio Ramon
García, Silvia R.
Stoker, Cora
De Jesús, Juan J.
Beldomenico, Pablo Martín
Ramos, Jorge Guillermo
Luque, Enrique Hugo
author Muñoz de Toro, Monica Milagros
author_facet Muñoz de Toro, Monica Milagros
Beldomenico, Horacio Ramon
García, Silvia R.
Stoker, Cora
De Jesús, Juan J.
Beldomenico, Pablo Martín
Ramos, Jorge Guillermo
Luque, Enrique Hugo
author_role author
author2 Beldomenico, Horacio Ramon
García, Silvia R.
Stoker, Cora
De Jesús, Juan J.
Beldomenico, Pablo Martín
Ramos, Jorge Guillermo
Luque, Enrique Hugo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BREAST TISSUE
DIET EXPOSURE
ENDOCRINE DISRUPTORS
ENVIRONMENTAL CONTAMINATION
PESTICIDES
topic BREAST TISSUE
DIET EXPOSURE
ENDOCRINE DISRUPTORS
ENVIRONMENTAL CONTAMINATION
PESTICIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls (PCBs), are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogen-like effects. Northeastern Argentina, near the Paraná River, is characterized by intensive farming and agricultural activities and industrial development, and is therefore prone to high incidences of environmental and dietary exposure to OCCs. Hence, we conducted a study to (1) estimate the organochlorine residues present in mammary fat tissue in a population of women from this littoral region and (2) identify potential sources of exposure to OCCs. Our subjects were 76 women (residing in and around Santa Fe city and not occupationally exposed to organochlorines) who underwent excision biopsy of a breast lesion or had plastic surgery. Both frequency of occurrence and levels of organochlorine residues were high in breast adipose tissue of all the participants. The organochlorine residues most frequently found were p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) in all the subjects analyzed, hexachlorobenzene (HCB) in 86.8%, and β-hexachlorocyclohexane (β-HCH) in 75.0%. The incidence of PCB congeners was very low. p,p′-DDE and β-HCH residues reached the highest levels, 4794 and 1780 ppb, respectively. The diet was a relevant source of exposure, consumption of animal fat and freshwater fish playing a significant role. Bioaccumulation was evidenced by the significant positive association between organochlorine levels and body mass index (p = 0.0 0 0 3) and the age of the patient (p = 0.0 0 0 2). The frequency and levels of OCCs found in our study population raise concerns regarding Argentinean exposure to these endocrine disruptors.
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Beldomenico, Horacio Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: García, Silvia R.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Stoker, Cora. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: De Jesús, Juan J.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Beldomenico, Pablo Martín. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Ramos, Jorge Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina
Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina
description Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls (PCBs), are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogen-like effects. Northeastern Argentina, near the Paraná River, is characterized by intensive farming and agricultural activities and industrial development, and is therefore prone to high incidences of environmental and dietary exposure to OCCs. Hence, we conducted a study to (1) estimate the organochlorine residues present in mammary fat tissue in a population of women from this littoral region and (2) identify potential sources of exposure to OCCs. Our subjects were 76 women (residing in and around Santa Fe city and not occupationally exposed to organochlorines) who underwent excision biopsy of a breast lesion or had plastic surgery. Both frequency of occurrence and levels of organochlorine residues were high in breast adipose tissue of all the participants. The organochlorine residues most frequently found were p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) in all the subjects analyzed, hexachlorobenzene (HCB) in 86.8%, and β-hexachlorocyclohexane (β-HCH) in 75.0%. The incidence of PCB congeners was very low. p,p′-DDE and β-HCH residues reached the highest levels, 4794 and 1780 ppb, respectively. The diet was a relevant source of exposure, consumption of animal fat and freshwater fish playing a significant role. Bioaccumulation was evidenced by the significant positive association between organochlorine levels and body mass index (p = 0.0 0 0 3) and the age of the patient (p = 0.0 0 0 2). The frequency and levels of OCCs found in our study population raise concerns regarding Argentinean exposure to these endocrine disruptors.
publishDate 2006
dc.date.none.fl_str_mv 2006-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99797
Muñoz de Toro, Monica Milagros; Beldomenico, Horacio Ramon; García, Silvia R.; Stoker, Cora; De Jesús, Juan J.; et al.; Organochlorine levels in adipose tissue of women from a littoral region of Argentina; Academic Press Inc Elsevier Science; Environmental Research; 102; 1; 9-2006; 107-112
0013-9351
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99797
identifier_str_mv Muñoz de Toro, Monica Milagros; Beldomenico, Horacio Ramon; García, Silvia R.; Stoker, Cora; De Jesús, Juan J.; et al.; Organochlorine levels in adipose tissue of women from a littoral region of Argentina; Academic Press Inc Elsevier Science; Environmental Research; 102; 1; 9-2006; 107-112
0013-9351
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2005.12.017
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0013935105002069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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