Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome

Autores
Exeni, Ramón A.; Fernández, Gabriela Cristina; Palermo, Marina Sandra
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thrombotic microangiopathy and acute renal failure are cardinal features of post-diarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a Gram-negative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patient's studies in an attempt to elucidate the pathogenic mechanisms of HUS. ©2007 with author. Published by TheScientificWorld.
Fil: Exeni, Ramón A.. Hospital Municipal del Niño; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Materia
HEMOLYTIC UREMIC SYNDROME
INFLAMMATION
MOUSE MODEL
PATIENTS
POLYMORPHONUCLEAR NEUTROPHILS
TYPICAL HUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55919
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndromeExeni, Ramón A.Fernández, Gabriela CristinaPalermo, Marina SandraHEMOLYTIC UREMIC SYNDROMEINFLAMMATIONMOUSE MODELPATIENTSPOLYMORPHONUCLEAR NEUTROPHILSTYPICAL HUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Thrombotic microangiopathy and acute renal failure are cardinal features of post-diarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a Gram-negative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patient's studies in an attempt to elucidate the pathogenic mechanisms of HUS. ©2007 with author. Published by TheScientificWorld.Fil: Exeni, Ramón A.. Hospital Municipal del Niño; ArgentinaFil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaHINDAWI publishing Corporation2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55919Exeni, Ramón A.; Fernández, Gabriela Cristina; Palermo, Marina Sandra; Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome; HINDAWI publishing Corporation; Scientific World Journal; 7; 8-2007; 1155-11641537-744XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1100/tsw.2007.172info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/tswj/2007/131386/abs/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:06:12Zoai:ri.conicet.gov.ar:11336/55919instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:06:12.392CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
title Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
spellingShingle Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
Exeni, Ramón A.
HEMOLYTIC UREMIC SYNDROME
INFLAMMATION
MOUSE MODEL
PATIENTS
POLYMORPHONUCLEAR NEUTROPHILS
TYPICAL HUS
title_short Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
title_full Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
title_fullStr Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
title_full_unstemmed Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
title_sort Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
dc.creator.none.fl_str_mv Exeni, Ramón A.
Fernández, Gabriela Cristina
Palermo, Marina Sandra
author Exeni, Ramón A.
author_facet Exeni, Ramón A.
Fernández, Gabriela Cristina
Palermo, Marina Sandra
author_role author
author2 Fernández, Gabriela Cristina
Palermo, Marina Sandra
author2_role author
author
dc.subject.none.fl_str_mv HEMOLYTIC UREMIC SYNDROME
INFLAMMATION
MOUSE MODEL
PATIENTS
POLYMORPHONUCLEAR NEUTROPHILS
TYPICAL HUS
topic HEMOLYTIC UREMIC SYNDROME
INFLAMMATION
MOUSE MODEL
PATIENTS
POLYMORPHONUCLEAR NEUTROPHILS
TYPICAL HUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Thrombotic microangiopathy and acute renal failure are cardinal features of post-diarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a Gram-negative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patient's studies in an attempt to elucidate the pathogenic mechanisms of HUS. ©2007 with author. Published by TheScientificWorld.
Fil: Exeni, Ramón A.. Hospital Municipal del Niño; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
description Thrombotic microangiopathy and acute renal failure are cardinal features of post-diarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a Gram-negative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patient's studies in an attempt to elucidate the pathogenic mechanisms of HUS. ©2007 with author. Published by TheScientificWorld.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55919
Exeni, Ramón A.; Fernández, Gabriela Cristina; Palermo, Marina Sandra; Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome; HINDAWI publishing Corporation; Scientific World Journal; 7; 8-2007; 1155-1164
1537-744X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55919
identifier_str_mv Exeni, Ramón A.; Fernández, Gabriela Cristina; Palermo, Marina Sandra; Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome; HINDAWI publishing Corporation; Scientific World Journal; 7; 8-2007; 1155-1164
1537-744X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1100/tsw.2007.172
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/tswj/2007/131386/abs/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv HINDAWI publishing Corporation
publisher.none.fl_str_mv HINDAWI publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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