Brain folding shapes the branching pattern of the middle cerebral artery

Autores
Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.
Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mallela, Arka. University of Pittsburgh; Estados Unidos
Fil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; Argentina
Fil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados Unidos
Materia
brain
folding
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182217
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Brain folding shapes the branching pattern of the middle cerebral arteryShalóm, Diego EdgarTrevisan, Marcos AlbertoMallela, ArkaNuñez, MaximilianoGoldschmidt, Ezequiel Daríobrainfoldinghttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Mallela, Arka. University of Pittsburgh; Estados UnidosFil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; ArgentinaFil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados UnidosPublic Library of Science2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182217Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-131932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245167info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0245167info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:18:46Zoai:ri.conicet.gov.ar:11336/182217instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:18:46.904CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain folding shapes the branching pattern of the middle cerebral artery
title Brain folding shapes the branching pattern of the middle cerebral artery
spellingShingle Brain folding shapes the branching pattern of the middle cerebral artery
Shalóm, Diego Edgar
brain
folding
title_short Brain folding shapes the branching pattern of the middle cerebral artery
title_full Brain folding shapes the branching pattern of the middle cerebral artery
title_fullStr Brain folding shapes the branching pattern of the middle cerebral artery
title_full_unstemmed Brain folding shapes the branching pattern of the middle cerebral artery
title_sort Brain folding shapes the branching pattern of the middle cerebral artery
dc.creator.none.fl_str_mv Shalóm, Diego Edgar
Trevisan, Marcos Alberto
Mallela, Arka
Nuñez, Maximiliano
Goldschmidt, Ezequiel Darío
author Shalóm, Diego Edgar
author_facet Shalóm, Diego Edgar
Trevisan, Marcos Alberto
Mallela, Arka
Nuñez, Maximiliano
Goldschmidt, Ezequiel Darío
author_role author
author2 Trevisan, Marcos Alberto
Mallela, Arka
Nuñez, Maximiliano
Goldschmidt, Ezequiel Darío
author2_role author
author
author
author
dc.subject.none.fl_str_mv brain
folding
topic brain
folding
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.
Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mallela, Arka. University of Pittsburgh; Estados Unidos
Fil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; Argentina
Fil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados Unidos
description The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182217
Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-13
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182217
identifier_str_mv Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-13
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245167
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0245167
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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