Brain folding shapes the branching pattern of the middle cerebral artery
- Autores
- Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.
Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mallela, Arka. University of Pittsburgh; Estados Unidos
Fil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; Argentina
Fil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados Unidos - Materia
-
brain
folding - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/182217
Ver los metadatos del registro completo
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Brain folding shapes the branching pattern of the middle cerebral arteryShalóm, Diego EdgarTrevisan, Marcos AlbertoMallela, ArkaNuñez, MaximilianoGoldschmidt, Ezequiel Daríobrainfoldinghttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Mallela, Arka. University of Pittsburgh; Estados UnidosFil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; ArgentinaFil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados UnidosPublic Library of Science2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182217Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-131932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245167info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0245167info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:20Zoai:ri.conicet.gov.ar:11336/182217instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:20.722CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Brain folding shapes the branching pattern of the middle cerebral artery |
title |
Brain folding shapes the branching pattern of the middle cerebral artery |
spellingShingle |
Brain folding shapes the branching pattern of the middle cerebral artery Shalóm, Diego Edgar brain folding |
title_short |
Brain folding shapes the branching pattern of the middle cerebral artery |
title_full |
Brain folding shapes the branching pattern of the middle cerebral artery |
title_fullStr |
Brain folding shapes the branching pattern of the middle cerebral artery |
title_full_unstemmed |
Brain folding shapes the branching pattern of the middle cerebral artery |
title_sort |
Brain folding shapes the branching pattern of the middle cerebral artery |
dc.creator.none.fl_str_mv |
Shalóm, Diego Edgar Trevisan, Marcos Alberto Mallela, Arka Nuñez, Maximiliano Goldschmidt, Ezequiel Darío |
author |
Shalóm, Diego Edgar |
author_facet |
Shalóm, Diego Edgar Trevisan, Marcos Alberto Mallela, Arka Nuñez, Maximiliano Goldschmidt, Ezequiel Darío |
author_role |
author |
author2 |
Trevisan, Marcos Alberto Mallela, Arka Nuñez, Maximiliano Goldschmidt, Ezequiel Darío |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
brain folding |
topic |
brain folding |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.7 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions. Fil: Shalóm, Diego Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Trevisan, Marcos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Mallela, Arka. University of Pittsburgh; Estados Unidos Fil: Nuñez, Maximiliano. Gobierno de la Provincia de Buenos Aires. Hospital El Cruce Doctor Néstor Carlos Kirchner. Centro de Medicina Traslacional; Argentina Fil: Goldschmidt, Ezequiel Darío. University of Pittsburgh; Estados Unidos |
description |
The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/182217 Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-13 1932-6203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/182217 |
identifier_str_mv |
Shalóm, Diego Edgar; Trevisan, Marcos Alberto; Mallela, Arka; Nuñez, Maximiliano; Goldschmidt, Ezequiel Darío; Brain folding shapes the branching pattern of the middle cerebral artery; Public Library of Science; Plos One; 16; 1; 1-2021; 1-13 1932-6203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245167 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0245167 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613528443420672 |
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13.070432 |