Intelligence and executive functions in frontotemporal dementia

Autores
Roca, María; Manes, Facundo Francisco; Gleichgerrcht, Ezequiel; Watson, Peter; Ibañez, Agustin Mariano; Thompson, Russell; Torralva, Teresa; Duncan, John
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman’s g) to define two sets of frontal lobe or “executive” tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g.
Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Gleichgerrcht, Ezequiel. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Watson, Peter. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
Fil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Thompson, Russell. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Duncan, John. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
Materia
Frontotemporal Dementia
Fluid Intelligence
Executive Functions
Theory Ofmind
Multitasking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22063
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Intelligence and executive functions in frontotemporal dementiaRoca, MaríaManes, Facundo FranciscoGleichgerrcht, EzequielWatson, PeterIbañez, Agustin MarianoThompson, RussellTorralva, TeresaDuncan, JohnFrontotemporal DementiaFluid IntelligenceExecutive FunctionsTheory OfmindMultitaskinghttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman’s g) to define two sets of frontal lobe or “executive” tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g.Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manes, Facundo Francisco. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Gleichgerrcht, Ezequiel. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Watson, Peter. Medical Research Council. Cognition and Brain Sciences Unit; Reino UnidoFil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Thompson, Russell. Medical Research Council. Cognition and Brain Sciences Unit; Reino UnidoFil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Duncan, John. Medical Research Council. Cognition and Brain Sciences Unit; Reino UnidoElsevier2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22063Roca, María; Manes, Facundo Francisco; Gleichgerrcht, Ezequiel; Watson, Peter; Ibañez, Agustin Mariano; et al.; Intelligence and executive functions in frontotemporal dementia; Elsevier; Neuropsychologia; 51; 4; 3-2013; 725-7300028-3932CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0028393213000146info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuropsychologia.2013.01.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:48Zoai:ri.conicet.gov.ar:11336/22063instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:48.387CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Intelligence and executive functions in frontotemporal dementia
title Intelligence and executive functions in frontotemporal dementia
spellingShingle Intelligence and executive functions in frontotemporal dementia
Roca, María
Frontotemporal Dementia
Fluid Intelligence
Executive Functions
Theory Ofmind
Multitasking
title_short Intelligence and executive functions in frontotemporal dementia
title_full Intelligence and executive functions in frontotemporal dementia
title_fullStr Intelligence and executive functions in frontotemporal dementia
title_full_unstemmed Intelligence and executive functions in frontotemporal dementia
title_sort Intelligence and executive functions in frontotemporal dementia
dc.creator.none.fl_str_mv Roca, María
Manes, Facundo Francisco
Gleichgerrcht, Ezequiel
Watson, Peter
Ibañez, Agustin Mariano
Thompson, Russell
Torralva, Teresa
Duncan, John
author Roca, María
author_facet Roca, María
Manes, Facundo Francisco
Gleichgerrcht, Ezequiel
Watson, Peter
Ibañez, Agustin Mariano
Thompson, Russell
Torralva, Teresa
Duncan, John
author_role author
author2 Manes, Facundo Francisco
Gleichgerrcht, Ezequiel
Watson, Peter
Ibañez, Agustin Mariano
Thompson, Russell
Torralva, Teresa
Duncan, John
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Frontotemporal Dementia
Fluid Intelligence
Executive Functions
Theory Ofmind
Multitasking
topic Frontotemporal Dementia
Fluid Intelligence
Executive Functions
Theory Ofmind
Multitasking
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman’s g) to define two sets of frontal lobe or “executive” tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g.
Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Gleichgerrcht, Ezequiel. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Watson, Peter. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
Fil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Thompson, Russell. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Duncan, John. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido
description Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman’s g) to define two sets of frontal lobe or “executive” tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22063
Roca, María; Manes, Facundo Francisco; Gleichgerrcht, Ezequiel; Watson, Peter; Ibañez, Agustin Mariano; et al.; Intelligence and executive functions in frontotemporal dementia; Elsevier; Neuropsychologia; 51; 4; 3-2013; 725-730
0028-3932
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22063
identifier_str_mv Roca, María; Manes, Facundo Francisco; Gleichgerrcht, Ezequiel; Watson, Peter; Ibañez, Agustin Mariano; et al.; Intelligence and executive functions in frontotemporal dementia; Elsevier; Neuropsychologia; 51; 4; 3-2013; 725-730
0028-3932
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0028393213000146
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuropsychologia.2013.01.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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