Histone methylations in the developing central nervous system and in neural tube defects

Autores
Villarreal, Alejandro; Franz, Henriette; Vogel, Tanja
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms regulate gene expression in a spatio-temporal manner and are implicated in diverse cellular actions one of which is cell differentiation. Therefore, the study of these mechanisms is of great relevance in the context of development and disease. In this article, we will review histone methylations as epigenetic modification and how they impact on gene expression and cell differentiation in central nervous system development and neural differentiation. Further, we will discuss an emerging link between histone methylation in the etiology of neural tube defects. We will specifically highlight the role of the disruptor of telomeric silencing like 1 (DOT1L) and histone H3 lysine 79 methylation (H3K79me), which is an unusual histone modification with implication for proper central nervous system development.
Fil: Villarreal, Alejandro. Institute Of Anatomy And Cell Biology; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Franz, Henriette. Institute Of Anatomy And Cell Biology; Alemania
Fil: Vogel, Tanja. Institute Of Anatomy And Cell Biology; Alemania
Materia
DEVELOPMENT
EPIGENETICS
HISTONE METHYLATION
NEURAL DIFFERENTIATION
NEURAL TUBE DEFECTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/90461
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Histone methylations in the developing central nervous system and in neural tube defectsVillarreal, AlejandroFranz, HenrietteVogel, TanjaDEVELOPMENTEPIGENETICSHISTONE METHYLATIONNEURAL DIFFERENTIATIONNEURAL TUBE DEFECTShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms regulate gene expression in a spatio-temporal manner and are implicated in diverse cellular actions one of which is cell differentiation. Therefore, the study of these mechanisms is of great relevance in the context of development and disease. In this article, we will review histone methylations as epigenetic modification and how they impact on gene expression and cell differentiation in central nervous system development and neural differentiation. Further, we will discuss an emerging link between histone methylation in the etiology of neural tube defects. We will specifically highlight the role of the disruptor of telomeric silencing like 1 (DOT1L) and histone H3 lysine 79 methylation (H3K79me), which is an unusual histone modification with implication for proper central nervous system development.Fil: Villarreal, Alejandro. Institute Of Anatomy And Cell Biology; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Franz, Henriette. Institute Of Anatomy And Cell Biology; AlemaniaFil: Vogel, Tanja. Institute Of Anatomy And Cell Biology; AlemaniaDe Gruyter2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90461Villarreal, Alejandro; Franz, Henriette; Vogel, Tanja; Histone methylations in the developing central nervous system and in neural tube defects; De Gruyter; Neuroforum; 24; 2; 5-2018; A85-A942363-70130947-0875CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/nf.ahead-of-print/nf-2018-A001/nf-2018-A001.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/nf-2018-A001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:41Zoai:ri.conicet.gov.ar:11336/90461instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:42.081CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histone methylations in the developing central nervous system and in neural tube defects
title Histone methylations in the developing central nervous system and in neural tube defects
spellingShingle Histone methylations in the developing central nervous system and in neural tube defects
Villarreal, Alejandro
DEVELOPMENT
EPIGENETICS
HISTONE METHYLATION
NEURAL DIFFERENTIATION
NEURAL TUBE DEFECTS
title_short Histone methylations in the developing central nervous system and in neural tube defects
title_full Histone methylations in the developing central nervous system and in neural tube defects
title_fullStr Histone methylations in the developing central nervous system and in neural tube defects
title_full_unstemmed Histone methylations in the developing central nervous system and in neural tube defects
title_sort Histone methylations in the developing central nervous system and in neural tube defects
dc.creator.none.fl_str_mv Villarreal, Alejandro
Franz, Henriette
Vogel, Tanja
author Villarreal, Alejandro
author_facet Villarreal, Alejandro
Franz, Henriette
Vogel, Tanja
author_role author
author2 Franz, Henriette
Vogel, Tanja
author2_role author
author
dc.subject.none.fl_str_mv DEVELOPMENT
EPIGENETICS
HISTONE METHYLATION
NEURAL DIFFERENTIATION
NEURAL TUBE DEFECTS
topic DEVELOPMENT
EPIGENETICS
HISTONE METHYLATION
NEURAL DIFFERENTIATION
NEURAL TUBE DEFECTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms regulate gene expression in a spatio-temporal manner and are implicated in diverse cellular actions one of which is cell differentiation. Therefore, the study of these mechanisms is of great relevance in the context of development and disease. In this article, we will review histone methylations as epigenetic modification and how they impact on gene expression and cell differentiation in central nervous system development and neural differentiation. Further, we will discuss an emerging link between histone methylation in the etiology of neural tube defects. We will specifically highlight the role of the disruptor of telomeric silencing like 1 (DOT1L) and histone H3 lysine 79 methylation (H3K79me), which is an unusual histone modification with implication for proper central nervous system development.
Fil: Villarreal, Alejandro. Institute Of Anatomy And Cell Biology; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Franz, Henriette. Institute Of Anatomy And Cell Biology; Alemania
Fil: Vogel, Tanja. Institute Of Anatomy And Cell Biology; Alemania
description Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms regulate gene expression in a spatio-temporal manner and are implicated in diverse cellular actions one of which is cell differentiation. Therefore, the study of these mechanisms is of great relevance in the context of development and disease. In this article, we will review histone methylations as epigenetic modification and how they impact on gene expression and cell differentiation in central nervous system development and neural differentiation. Further, we will discuss an emerging link between histone methylation in the etiology of neural tube defects. We will specifically highlight the role of the disruptor of telomeric silencing like 1 (DOT1L) and histone H3 lysine 79 methylation (H3K79me), which is an unusual histone modification with implication for proper central nervous system development.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/90461
Villarreal, Alejandro; Franz, Henriette; Vogel, Tanja; Histone methylations in the developing central nervous system and in neural tube defects; De Gruyter; Neuroforum; 24; 2; 5-2018; A85-A94
2363-7013
0947-0875
CONICET Digital
CONICET
url http://hdl.handle.net/11336/90461
identifier_str_mv Villarreal, Alejandro; Franz, Henriette; Vogel, Tanja; Histone methylations in the developing central nervous system and in neural tube defects; De Gruyter; Neuroforum; 24; 2; 5-2018; A85-A94
2363-7013
0947-0875
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/nf.ahead-of-print/nf-2018-A001/nf-2018-A001.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/nf-2018-A001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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