Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful

Autores
Sosnik, Alejandro Dario; Gotelli, Gustavo A.; Abraham, Gustavo Abel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lack of reproducibility, difficult and expensive scale-up and standarization of synthetic processes are the main hurdles towards the industrial production of raw synthetic and semi-synthetic polymers for (bio)pharmaceutical applications. Time- and energy-consuming synthetic pathways that usually involve the use of volatile, flammable or toxic organic solvents are apparently cost-viable and environment-friendly for the synthesis at a laboratory scale. However, they are often not viable in industrial settings especially due to the impact they have on the product cost and the deleterious effect on the environment. This has presented hurdles to the incorporation of many new biomaterials displaying novel structural features into clinics. Nevertheless, owing to unique advantages such as shorter reaction times, higher yields, limited generation of by-products and relatively easy scale-up without detrimental effects, microwave-assisted organic synthesis has become an appealing synthetic tool. Regardless of these features, the use of microwave radiation in biomaterials science has been comparatively scarce. A growing interest in the basic aspects of the synthesis of either ceramic and polymeric biomaterials has been apparent during the last decade. This article reviews the most recent and prominent applications of MW as a versatile tool to synthesize and process organic and inorganic polymeric biomaterials, and discusses the unmet goals and the perspectives for a technology that probably has the potential to make biomaterials more accessible pharmaceutical excipients and the products that involve them more affordable to patients.
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Gotelli, Gustavo A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
BIOMEDICAL COMPOSITES
EMULSION IN SITU POLYMERIZATION
GRAFT POLYMERIZATION
HYDROGELS
MICROWAVE IRRADIATION
RING OPENING POLYMERIZATION
SYNTHESIS OF POLYMERIC BIOMATERIALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163279
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/163279
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerfulSosnik, Alejandro DarioGotelli, Gustavo A.Abraham, Gustavo AbelBIOMEDICAL COMPOSITESEMULSION IN SITU POLYMERIZATIONGRAFT POLYMERIZATIONHYDROGELSMICROWAVE IRRADIATIONRING OPENING POLYMERIZATIONSYNTHESIS OF POLYMERIC BIOMATERIALShttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Lack of reproducibility, difficult and expensive scale-up and standarization of synthetic processes are the main hurdles towards the industrial production of raw synthetic and semi-synthetic polymers for (bio)pharmaceutical applications. Time- and energy-consuming synthetic pathways that usually involve the use of volatile, flammable or toxic organic solvents are apparently cost-viable and environment-friendly for the synthesis at a laboratory scale. However, they are often not viable in industrial settings especially due to the impact they have on the product cost and the deleterious effect on the environment. This has presented hurdles to the incorporation of many new biomaterials displaying novel structural features into clinics. Nevertheless, owing to unique advantages such as shorter reaction times, higher yields, limited generation of by-products and relatively easy scale-up without detrimental effects, microwave-assisted organic synthesis has become an appealing synthetic tool. Regardless of these features, the use of microwave radiation in biomaterials science has been comparatively scarce. A growing interest in the basic aspects of the synthesis of either ceramic and polymeric biomaterials has been apparent during the last decade. This article reviews the most recent and prominent applications of MW as a versatile tool to synthesize and process organic and inorganic polymeric biomaterials, and discusses the unmet goals and the perspectives for a technology that probably has the potential to make biomaterials more accessible pharmaceutical excipients and the products that involve them more affordable to patients.Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Gotelli, Gustavo A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaPergamon-Elsevier Science Ltd2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163279Sosnik, Alejandro Dario; Gotelli, Gustavo A.; Abraham, Gustavo Abel; Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful; Pergamon-Elsevier Science Ltd; PROGRESS IN POLYMER SCIENCE - (Print); 36; 8; 8-2011; 1050-10780079-6700CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0079670010001255info:eu-repo/semantics/altIdentifier/doi/10.1016/j.progpolymsci.2010.12.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:02Zoai:ri.conicet.gov.ar:11336/163279instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:02.848CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
title Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
spellingShingle Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
Sosnik, Alejandro Dario
BIOMEDICAL COMPOSITES
EMULSION IN SITU POLYMERIZATION
GRAFT POLYMERIZATION
HYDROGELS
MICROWAVE IRRADIATION
RING OPENING POLYMERIZATION
SYNTHESIS OF POLYMERIC BIOMATERIALS
title_short Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
title_full Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
title_fullStr Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
title_full_unstemmed Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
title_sort Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful
dc.creator.none.fl_str_mv Sosnik, Alejandro Dario
Gotelli, Gustavo A.
Abraham, Gustavo Abel
author Sosnik, Alejandro Dario
author_facet Sosnik, Alejandro Dario
Gotelli, Gustavo A.
Abraham, Gustavo Abel
author_role author
author2 Gotelli, Gustavo A.
Abraham, Gustavo Abel
author2_role author
author
dc.subject.none.fl_str_mv BIOMEDICAL COMPOSITES
EMULSION IN SITU POLYMERIZATION
GRAFT POLYMERIZATION
HYDROGELS
MICROWAVE IRRADIATION
RING OPENING POLYMERIZATION
SYNTHESIS OF POLYMERIC BIOMATERIALS
topic BIOMEDICAL COMPOSITES
EMULSION IN SITU POLYMERIZATION
GRAFT POLYMERIZATION
HYDROGELS
MICROWAVE IRRADIATION
RING OPENING POLYMERIZATION
SYNTHESIS OF POLYMERIC BIOMATERIALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Lack of reproducibility, difficult and expensive scale-up and standarization of synthetic processes are the main hurdles towards the industrial production of raw synthetic and semi-synthetic polymers for (bio)pharmaceutical applications. Time- and energy-consuming synthetic pathways that usually involve the use of volatile, flammable or toxic organic solvents are apparently cost-viable and environment-friendly for the synthesis at a laboratory scale. However, they are often not viable in industrial settings especially due to the impact they have on the product cost and the deleterious effect on the environment. This has presented hurdles to the incorporation of many new biomaterials displaying novel structural features into clinics. Nevertheless, owing to unique advantages such as shorter reaction times, higher yields, limited generation of by-products and relatively easy scale-up without detrimental effects, microwave-assisted organic synthesis has become an appealing synthetic tool. Regardless of these features, the use of microwave radiation in biomaterials science has been comparatively scarce. A growing interest in the basic aspects of the synthesis of either ceramic and polymeric biomaterials has been apparent during the last decade. This article reviews the most recent and prominent applications of MW as a versatile tool to synthesize and process organic and inorganic polymeric biomaterials, and discusses the unmet goals and the perspectives for a technology that probably has the potential to make biomaterials more accessible pharmaceutical excipients and the products that involve them more affordable to patients.
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Gotelli, Gustavo A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description Lack of reproducibility, difficult and expensive scale-up and standarization of synthetic processes are the main hurdles towards the industrial production of raw synthetic and semi-synthetic polymers for (bio)pharmaceutical applications. Time- and energy-consuming synthetic pathways that usually involve the use of volatile, flammable or toxic organic solvents are apparently cost-viable and environment-friendly for the synthesis at a laboratory scale. However, they are often not viable in industrial settings especially due to the impact they have on the product cost and the deleterious effect on the environment. This has presented hurdles to the incorporation of many new biomaterials displaying novel structural features into clinics. Nevertheless, owing to unique advantages such as shorter reaction times, higher yields, limited generation of by-products and relatively easy scale-up without detrimental effects, microwave-assisted organic synthesis has become an appealing synthetic tool. Regardless of these features, the use of microwave radiation in biomaterials science has been comparatively scarce. A growing interest in the basic aspects of the synthesis of either ceramic and polymeric biomaterials has been apparent during the last decade. This article reviews the most recent and prominent applications of MW as a versatile tool to synthesize and process organic and inorganic polymeric biomaterials, and discusses the unmet goals and the perspectives for a technology that probably has the potential to make biomaterials more accessible pharmaceutical excipients and the products that involve them more affordable to patients.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163279
Sosnik, Alejandro Dario; Gotelli, Gustavo A.; Abraham, Gustavo Abel; Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful; Pergamon-Elsevier Science Ltd; PROGRESS IN POLYMER SCIENCE - (Print); 36; 8; 8-2011; 1050-1078
0079-6700
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163279
identifier_str_mv Sosnik, Alejandro Dario; Gotelli, Gustavo A.; Abraham, Gustavo Abel; Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful; Pergamon-Elsevier Science Ltd; PROGRESS IN POLYMER SCIENCE - (Print); 36; 8; 8-2011; 1050-1078
0079-6700
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0079670010001255
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.progpolymsci.2010.12.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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