Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations

Autores
Nuñez, Sebastián; Garelli, Fabricio; de Battista, Hernan
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, a control strategy to guarantee a minimum dissolved oxygen concentration in aerobic fed-batch bioprocesses is proposed. The strategy is equally applicable to avoid low oxygen concentrations that might be detrimental for metabolites production, to prevent metabolic changes and to maintain an oxygen level in the culture compatible with the desired growth rate during the growing phase of the process. It essentially consists in adapting the set-point of the feeding controller to cope with faults and saturation in the oxygen regulation subsystem. The idea behind this adaptation is to manipulate, when necessary, the oxygen consumption in such a way that the oxygen in the culture is maintained above a prescribed threshold. The algorithm is based on sliding mode techniques, and its main features are as follows: simplicity, robustness to process uncertainties, easy implementation, and versatility to be combined with different dissolved oxygen and feeding controllers. The method is assessed numerically in a fed-batch growth phase of Pichia pastoris where an oxygen shortage leads to excessive glycerol accumulation.
Fil: Nuñez, Sebastián. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Decentralized Control
Aerobic Fermentations
Do Control
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13617
Acceder
id CONICETDig_cdf35c63d632301344ac49024e17fdd3
oai_identifier_str oai:ri.conicet.gov.ar:11336/13617
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivationsNuñez, SebastiánGarelli, Fabriciode Battista, HernanDecentralized ControlAerobic FermentationsDo Controlhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2In this work, a control strategy to guarantee a minimum dissolved oxygen concentration in aerobic fed-batch bioprocesses is proposed. The strategy is equally applicable to avoid low oxygen concentrations that might be detrimental for metabolites production, to prevent metabolic changes and to maintain an oxygen level in the culture compatible with the desired growth rate during the growing phase of the process. It essentially consists in adapting the set-point of the feeding controller to cope with faults and saturation in the oxygen regulation subsystem. The idea behind this adaptation is to manipulate, when necessary, the oxygen consumption in such a way that the oxygen in the culture is maintained above a prescribed threshold. The algorithm is based on sliding mode techniques, and its main features are as follows: simplicity, robustness to process uncertainties, easy implementation, and versatility to be combined with different dissolved oxygen and feeding controllers. The method is assessed numerically in a fed-batch growth phase of Pichia pastoris where an oxygen shortage leads to excessive glycerol accumulation.Fil: Nuñez, Sebastián. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Chemical Society2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13617Nuñez, Sebastián; Garelli, Fabricio; de Battista, Hernan; Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations; American Chemical Society; Industrial & Engineering Chemical Research; 52; 50; 12-2013; 18014-180210888-58851520-5045enginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ie4021107info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie4021107info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:35Zoai:ri.conicet.gov.ar:11336/13617instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:36.2CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
title Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
spellingShingle Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
Nuñez, Sebastián
Decentralized Control
Aerobic Fermentations
Do Control
title_short Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
title_full Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
title_fullStr Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
title_full_unstemmed Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
title_sort Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations
dc.creator.none.fl_str_mv Nuñez, Sebastián
Garelli, Fabricio
de Battista, Hernan
author Nuñez, Sebastián
author_facet Nuñez, Sebastián
Garelli, Fabricio
de Battista, Hernan
author_role author
author2 Garelli, Fabricio
de Battista, Hernan
author2_role author
author
dc.subject.none.fl_str_mv Decentralized Control
Aerobic Fermentations
Do Control
topic Decentralized Control
Aerobic Fermentations
Do Control
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work, a control strategy to guarantee a minimum dissolved oxygen concentration in aerobic fed-batch bioprocesses is proposed. The strategy is equally applicable to avoid low oxygen concentrations that might be detrimental for metabolites production, to prevent metabolic changes and to maintain an oxygen level in the culture compatible with the desired growth rate during the growing phase of the process. It essentially consists in adapting the set-point of the feeding controller to cope with faults and saturation in the oxygen regulation subsystem. The idea behind this adaptation is to manipulate, when necessary, the oxygen consumption in such a way that the oxygen in the culture is maintained above a prescribed threshold. The algorithm is based on sliding mode techniques, and its main features are as follows: simplicity, robustness to process uncertainties, easy implementation, and versatility to be combined with different dissolved oxygen and feeding controllers. The method is assessed numerically in a fed-batch growth phase of Pichia pastoris where an oxygen shortage leads to excessive glycerol accumulation.
Fil: Nuñez, Sebastián. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In this work, a control strategy to guarantee a minimum dissolved oxygen concentration in aerobic fed-batch bioprocesses is proposed. The strategy is equally applicable to avoid low oxygen concentrations that might be detrimental for metabolites production, to prevent metabolic changes and to maintain an oxygen level in the culture compatible with the desired growth rate during the growing phase of the process. It essentially consists in adapting the set-point of the feeding controller to cope with faults and saturation in the oxygen regulation subsystem. The idea behind this adaptation is to manipulate, when necessary, the oxygen consumption in such a way that the oxygen in the culture is maintained above a prescribed threshold. The algorithm is based on sliding mode techniques, and its main features are as follows: simplicity, robustness to process uncertainties, easy implementation, and versatility to be combined with different dissolved oxygen and feeding controllers. The method is assessed numerically in a fed-batch growth phase of Pichia pastoris where an oxygen shortage leads to excessive glycerol accumulation.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13617
Nuñez, Sebastián; Garelli, Fabricio; de Battista, Hernan; Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations; American Chemical Society; Industrial & Engineering Chemical Research; 52; 50; 12-2013; 18014-18021
0888-5885
1520-5045
url http://hdl.handle.net/11336/13617
identifier_str_mv Nuñez, Sebastián; Garelli, Fabricio; de Battista, Hernan; Decentralized control with minimum dissolved oxygen guaranties in aerobic fed-batch cultivations; American Chemical Society; Industrial & Engineering Chemical Research; 52; 50; 12-2013; 18014-18021
0888-5885
1520-5045
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/ie4021107
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie4021107
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269589930508288
score 12.984792

Publicaciones similares