Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway

Autores
Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; Arrizurieta, Elvira; Nowicki, Susana; Ibarra, Fernando R.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.
Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
Eicosanoides
Hipertension
Na,K-Atpasa
Dopamina
Hormonas Sexuales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8122

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oai_identifier_str oai:ri.conicet.gov.ar:11336/8122
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 PathwayDi Ciano, Luis A.Azurmendi, Pablo JavierColombero, CeciliaLevin, Gloria MabelOddo, Elisabet MónicaArrizurieta, ElviraNowicki, SusanaIbarra, Fernando R.EicosanoidesHipertensionNa,K-AtpasaDopaminaHormonas Sexualeshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaAmerican Physiological Society2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/8122Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-13681931-857Xenginfo:eu-repo/semantics/altIdentifier/url/http://ajprenal.physiology.org/content/early/2015/04/29/ajprenal.00450.2014info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.00450.2014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:50Zoai:ri.conicet.gov.ar:11336/8122instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:50.641CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
title Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
spellingShingle Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
Di Ciano, Luis A.
Eicosanoides
Hipertension
Na,K-Atpasa
Dopamina
Hormonas Sexuales
title_short Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
title_full Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
title_fullStr Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
title_full_unstemmed Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
title_sort Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
dc.creator.none.fl_str_mv Di Ciano, Luis A.
Azurmendi, Pablo Javier
Colombero, Cecilia
Levin, Gloria Mabel
Oddo, Elisabet Mónica
Arrizurieta, Elvira
Nowicki, Susana
Ibarra, Fernando R.
author Di Ciano, Luis A.
author_facet Di Ciano, Luis A.
Azurmendi, Pablo Javier
Colombero, Cecilia
Levin, Gloria Mabel
Oddo, Elisabet Mónica
Arrizurieta, Elvira
Nowicki, Susana
Ibarra, Fernando R.
author_role author
author2 Azurmendi, Pablo Javier
Colombero, Cecilia
Levin, Gloria Mabel
Oddo, Elisabet Mónica
Arrizurieta, Elvira
Nowicki, Susana
Ibarra, Fernando R.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Eicosanoides
Hipertension
Na,K-Atpasa
Dopamina
Hormonas Sexuales
topic Eicosanoides
Hipertension
Na,K-Atpasa
Dopamina
Hormonas Sexuales
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.
Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8122
Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-1368
1931-857X
url http://hdl.handle.net/11336/8122
identifier_str_mv Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-1368
1931-857X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ajprenal.physiology.org/content/early/2015/04/29/ajprenal.00450.2014
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.00450.2014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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