Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway
- Autores
- Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; Arrizurieta, Elvira; Nowicki, Susana; Ibarra, Fernando R.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.
Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina - Materia
-
Eicosanoides
Hipertension
Na,K-Atpasa
Dopamina
Hormonas Sexuales - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/8122
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Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 PathwayDi Ciano, Luis A.Azurmendi, Pablo JavierColombero, CeciliaLevin, Gloria MabelOddo, Elisabet MónicaArrizurieta, ElviraNowicki, SusanaIbarra, Fernando R.EicosanoidesHipertensionNa,K-AtpasaDopaminaHormonas Sexualeshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension.Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaAmerican Physiological Society2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/8122Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-13681931-857Xenginfo:eu-repo/semantics/altIdentifier/url/http://ajprenal.physiology.org/content/early/2015/04/29/ajprenal.00450.2014info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.00450.2014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:50Zoai:ri.conicet.gov.ar:11336/8122instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:50.641CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
title |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
spellingShingle |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway Di Ciano, Luis A. Eicosanoides Hipertension Na,K-Atpasa Dopamina Hormonas Sexuales |
title_short |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
title_full |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
title_fullStr |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
title_full_unstemmed |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
title_sort |
Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway |
dc.creator.none.fl_str_mv |
Di Ciano, Luis A. Azurmendi, Pablo Javier Colombero, Cecilia Levin, Gloria Mabel Oddo, Elisabet Mónica Arrizurieta, Elvira Nowicki, Susana Ibarra, Fernando R. |
author |
Di Ciano, Luis A. |
author_facet |
Di Ciano, Luis A. Azurmendi, Pablo Javier Colombero, Cecilia Levin, Gloria Mabel Oddo, Elisabet Mónica Arrizurieta, Elvira Nowicki, Susana Ibarra, Fernando R. |
author_role |
author |
author2 |
Azurmendi, Pablo Javier Colombero, Cecilia Levin, Gloria Mabel Oddo, Elisabet Mónica Arrizurieta, Elvira Nowicki, Susana Ibarra, Fernando R. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Eicosanoides Hipertension Na,K-Atpasa Dopamina Hormonas Sexuales |
topic |
Eicosanoides Hipertension Na,K-Atpasa Dopamina Hormonas Sexuales |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension. Fil: Di Ciano, Luis A.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina Fil: Colombero, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina Fil: Oddo, Elisabet Mónica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina Fil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina Fil: Ibarra, Fernando R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina |
description |
We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of total Na+, K+-ATPase α 1subunit (NKA). Upon high sodium (HS) intake ovariectomized (oVx) rats developed a defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in Cytochrome P4504A (CYP4A) expression and in 20-HETE production, while MBP kept normal. Blockade of D1R with the D1-like receptor antagonist SCH23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50 % and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both p<0.05), NKA was more dephosphorylated than in IFHS and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKCα expression did not vary among groups. The alteration of the renal dopamine system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load and the development of salt sensitive hypertension. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/8122 Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-1368 1931-857X |
url |
http://hdl.handle.net/11336/8122 |
identifier_str_mv |
Di Ciano, Luis A.; Azurmendi, Pablo Javier; Colombero, Cecilia; Levin, Gloria Mabel; Oddo, Elisabet Mónica; et al.; Defective Renal Dopamine Function and Sodium Sensitive Hypertension in Adult Ovariectomized Wistar Rats: Role of the Cytochrome P450 Pathway; American Physiological Society; American Journal Of Physiology-renal Physiology; 308; 12; 6-2015; 1358-1368 1931-857X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://ajprenal.physiology.org/content/early/2015/04/29/ajprenal.00450.2014 info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.00450.2014 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/zip application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society |
publisher.none.fl_str_mv |
American Physiological Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269930716659712 |
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13.13397 |