A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic

Autores
Bellotti, Mariela I.; Dellavale Clara, Hector Damian; Bonetto, Fabian Jose
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We developed a technique that detects superficial ocular pathologies based on the measurement of electrical impedance spectra. The sensor used is a small microelectrode made of platinum insulated from a cylindrical counterelectrode built of surgical stainless steel. The sensor has the shape of a truncated cone made of acrylic with dimensions identical to that of a standard Goldman prism. The sensor is applied to normal and pathological subject eyes with a constant force provided by a commercial tonometer. The circuit is closed through the lacrimal layer and the epithelial and endothelial cells. We measure the electrical impedance with a programmable logic device in which we implemented all the significant functions. These are the synthesis of the seventeen sines for the excitation, one lock-in, and delta-sigma modulators for the digital-to-analog converter and analog-to-digital converter requirements. A simple analog circuit filters the output, implements a voltage divider, and acts as current limiter in order not to damage the cells. We convert the measurements to resistance and capacitance as a function of frequencies. Consistent results are obtained for left and right eyes of the normal subjects. Significant differences are detected between the results for normal eyes and pathological eyes.
Fil: Bellotti, Mariela I.. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina
Fil: Dellavale Clara, Hector Damian. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Bonetto, Fabian Jose. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Materia
ELECTRICAL IMPEDANCE
LOCK-IN
OCULAR PATHOLOGIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/190865
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/190865
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logicBellotti, Mariela I.Dellavale Clara, Hector DamianBonetto, Fabian JoseELECTRICAL IMPEDANCELOCK-INOCULAR PATHOLOGIEShttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2We developed a technique that detects superficial ocular pathologies based on the measurement of electrical impedance spectra. The sensor used is a small microelectrode made of platinum insulated from a cylindrical counterelectrode built of surgical stainless steel. The sensor has the shape of a truncated cone made of acrylic with dimensions identical to that of a standard Goldman prism. The sensor is applied to normal and pathological subject eyes with a constant force provided by a commercial tonometer. The circuit is closed through the lacrimal layer and the epithelial and endothelial cells. We measure the electrical impedance with a programmable logic device in which we implemented all the significant functions. These are the synthesis of the seventeen sines for the excitation, one lock-in, and delta-sigma modulators for the digital-to-analog converter and analog-to-digital converter requirements. A simple analog circuit filters the output, implements a voltage divider, and acts as current limiter in order not to damage the cells. We convert the measurements to resistance and capacitance as a function of frequencies. Consistent results are obtained for left and right eyes of the normal subjects. Significant differences are detected between the results for normal eyes and pathological eyes.Fil: Bellotti, Mariela I.. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; ArgentinaFil: Dellavale Clara, Hector Damian. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Bonetto, Fabian Jose. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaInstitute of Electrical and Electronics Engineers2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/190865Bellotti, Mariela I.; Dellavale Clara, Hector Damian; Bonetto, Fabian Jose; A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic; Institute of Electrical and Electronics Engineers; Ieee Transactions on Instrumentation and Measurement; 61; 12; 9-2012; 3290-32940018-9456CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1109/TIM.2012.2210458info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:11:54Zoai:ri.conicet.gov.ar:11336/190865instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:11:55.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
title A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
spellingShingle A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
Bellotti, Mariela I.
ELECTRICAL IMPEDANCE
LOCK-IN
OCULAR PATHOLOGIES
title_short A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
title_full A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
title_fullStr A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
title_full_unstemmed A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
title_sort A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic
dc.creator.none.fl_str_mv Bellotti, Mariela I.
Dellavale Clara, Hector Damian
Bonetto, Fabian Jose
author Bellotti, Mariela I.
author_facet Bellotti, Mariela I.
Dellavale Clara, Hector Damian
Bonetto, Fabian Jose
author_role author
author2 Dellavale Clara, Hector Damian
Bonetto, Fabian Jose
author2_role author
author
dc.subject.none.fl_str_mv ELECTRICAL IMPEDANCE
LOCK-IN
OCULAR PATHOLOGIES
topic ELECTRICAL IMPEDANCE
LOCK-IN
OCULAR PATHOLOGIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv We developed a technique that detects superficial ocular pathologies based on the measurement of electrical impedance spectra. The sensor used is a small microelectrode made of platinum insulated from a cylindrical counterelectrode built of surgical stainless steel. The sensor has the shape of a truncated cone made of acrylic with dimensions identical to that of a standard Goldman prism. The sensor is applied to normal and pathological subject eyes with a constant force provided by a commercial tonometer. The circuit is closed through the lacrimal layer and the epithelial and endothelial cells. We measure the electrical impedance with a programmable logic device in which we implemented all the significant functions. These are the synthesis of the seventeen sines for the excitation, one lock-in, and delta-sigma modulators for the digital-to-analog converter and analog-to-digital converter requirements. A simple analog circuit filters the output, implements a voltage divider, and acts as current limiter in order not to damage the cells. We convert the measurements to resistance and capacitance as a function of frequencies. Consistent results are obtained for left and right eyes of the normal subjects. Significant differences are detected between the results for normal eyes and pathological eyes.
Fil: Bellotti, Mariela I.. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina
Fil: Dellavale Clara, Hector Damian. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Bonetto, Fabian Jose. Comisión Nacional de Energía Atómica. Gerencia de Área de Energía Nuclear. Gerencia de Ingeniería Nuclear (CAB). Laboratorio Cavitación y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
description We developed a technique that detects superficial ocular pathologies based on the measurement of electrical impedance spectra. The sensor used is a small microelectrode made of platinum insulated from a cylindrical counterelectrode built of surgical stainless steel. The sensor has the shape of a truncated cone made of acrylic with dimensions identical to that of a standard Goldman prism. The sensor is applied to normal and pathological subject eyes with a constant force provided by a commercial tonometer. The circuit is closed through the lacrimal layer and the epithelial and endothelial cells. We measure the electrical impedance with a programmable logic device in which we implemented all the significant functions. These are the synthesis of the seventeen sines for the excitation, one lock-in, and delta-sigma modulators for the digital-to-analog converter and analog-to-digital converter requirements. A simple analog circuit filters the output, implements a voltage divider, and acts as current limiter in order not to damage the cells. We convert the measurements to resistance and capacitance as a function of frequencies. Consistent results are obtained for left and right eyes of the normal subjects. Significant differences are detected between the results for normal eyes and pathological eyes.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/190865
Bellotti, Mariela I.; Dellavale Clara, Hector Damian; Bonetto, Fabian Jose; A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic; Institute of Electrical and Electronics Engineers; Ieee Transactions on Instrumentation and Measurement; 61; 12; 9-2012; 3290-3294
0018-9456
CONICET Digital
CONICET
url http://hdl.handle.net/11336/190865
identifier_str_mv Bellotti, Mariela I.; Dellavale Clara, Hector Damian; Bonetto, Fabian Jose; A new technique to detect ocular pathologies based on electrical measurement implemented on programmable logic; Institute of Electrical and Electronics Engineers; Ieee Transactions on Instrumentation and Measurement; 61; 12; 9-2012; 3290-3294
0018-9456
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1109/TIM.2012.2210458
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781503982272512
score 12.982451

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