Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications

Autores
Delpino, María Victoria; Quarleri, Jorge Fabian
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), has presented global challenges with adiverse clinical spectrum, including severe respiratory complications andsystemic effects. This review explores the intricate relationship betweenmitochondrial dysfunction, aging, and obesity in COVID-19. Mitochondria arevital for cellular energy provision and resilience against age-relatedmacromolecule damage accumulation. They manage energy allocation incells, activating adaptive responses and stress signals such as redox imbalanceand innate immunity activation. As organisms age, mitochondrial functiondiminishes. Aging and obesity, linked to mitochondrial dysfunction,compromise the antiviral response, affecting the release of interferons, andworsening COVID-19 severity. Furthermore, the development of post-acutesequelae of SARS-CoV-2 infection (PASC), also known as long COVID hasbeen associated with altered energy metabolism, and chronic immunedysregulation derived from mitochondrial dysfunction. Understanding theinterplay between mitochondria, aging, obesity, and viral infections providesinsights into COVID-19 pathogenesis. Targeting mitochondrial health mayoffer potential therapeutic strategies to mitigate severe outcomes and addresslong-term consequences in infected individuals.
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
SARS-COV-2
AGING
MITOCHONDRIA
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261909
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implicationsDelpino, María VictoriaQuarleri, Jorge FabianSARS-COV-2AGINGMITOCHONDRIACOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The coronavirus disease 2019 (COVID-19), caused by severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), has presented global challenges with adiverse clinical spectrum, including severe respiratory complications andsystemic effects. This review explores the intricate relationship betweenmitochondrial dysfunction, aging, and obesity in COVID-19. Mitochondria arevital for cellular energy provision and resilience against age-relatedmacromolecule damage accumulation. They manage energy allocation incells, activating adaptive responses and stress signals such as redox imbalanceand innate immunity activation. As organisms age, mitochondrial functiondiminishes. Aging and obesity, linked to mitochondrial dysfunction,compromise the antiviral response, affecting the release of interferons, andworsening COVID-19 severity. Furthermore, the development of post-acutesequelae of SARS-CoV-2 infection (PASC), also known as long COVID hasbeen associated with altered energy metabolism, and chronic immunedysregulation derived from mitochondrial dysfunction. Understanding theinterplay between mitochondria, aging, obesity, and viral infections providesinsights into COVID-19 pathogenesis. Targeting mitochondrial health mayoffer potential therapeutic strategies to mitigate severe outcomes and addresslong-term consequences in infected individuals.Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFrontiers Media2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261909Delpino, María Victoria; Quarleri, Jorge Fabian; Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications; Frontiers Media; Frontiers in Aging; 5; 9-2024; 1-122673-6217CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fragi.2024.1442323/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fragi.2024.1442323info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:10Zoai:ri.conicet.gov.ar:11336/261909instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:10.363CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
title Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
spellingShingle Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
Delpino, María Victoria
SARS-COV-2
AGING
MITOCHONDRIA
COVID-19
title_short Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
title_full Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
title_fullStr Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
title_full_unstemmed Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
title_sort Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
dc.creator.none.fl_str_mv Delpino, María Victoria
Quarleri, Jorge Fabian
author Delpino, María Victoria
author_facet Delpino, María Victoria
Quarleri, Jorge Fabian
author_role author
author2 Quarleri, Jorge Fabian
author2_role author
dc.subject.none.fl_str_mv SARS-COV-2
AGING
MITOCHONDRIA
COVID-19
topic SARS-COV-2
AGING
MITOCHONDRIA
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The coronavirus disease 2019 (COVID-19), caused by severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), has presented global challenges with adiverse clinical spectrum, including severe respiratory complications andsystemic effects. This review explores the intricate relationship betweenmitochondrial dysfunction, aging, and obesity in COVID-19. Mitochondria arevital for cellular energy provision and resilience against age-relatedmacromolecule damage accumulation. They manage energy allocation incells, activating adaptive responses and stress signals such as redox imbalanceand innate immunity activation. As organisms age, mitochondrial functiondiminishes. Aging and obesity, linked to mitochondrial dysfunction,compromise the antiviral response, affecting the release of interferons, andworsening COVID-19 severity. Furthermore, the development of post-acutesequelae of SARS-CoV-2 infection (PASC), also known as long COVID hasbeen associated with altered energy metabolism, and chronic immunedysregulation derived from mitochondrial dysfunction. Understanding theinterplay between mitochondria, aging, obesity, and viral infections providesinsights into COVID-19 pathogenesis. Targeting mitochondrial health mayoffer potential therapeutic strategies to mitigate severe outcomes and addresslong-term consequences in infected individuals.
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description The coronavirus disease 2019 (COVID-19), caused by severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), has presented global challenges with adiverse clinical spectrum, including severe respiratory complications andsystemic effects. This review explores the intricate relationship betweenmitochondrial dysfunction, aging, and obesity in COVID-19. Mitochondria arevital for cellular energy provision and resilience against age-relatedmacromolecule damage accumulation. They manage energy allocation incells, activating adaptive responses and stress signals such as redox imbalanceand innate immunity activation. As organisms age, mitochondrial functiondiminishes. Aging and obesity, linked to mitochondrial dysfunction,compromise the antiviral response, affecting the release of interferons, andworsening COVID-19 severity. Furthermore, the development of post-acutesequelae of SARS-CoV-2 infection (PASC), also known as long COVID hasbeen associated with altered energy metabolism, and chronic immunedysregulation derived from mitochondrial dysfunction. Understanding theinterplay between mitochondria, aging, obesity, and viral infections providesinsights into COVID-19 pathogenesis. Targeting mitochondrial health mayoffer potential therapeutic strategies to mitigate severe outcomes and addresslong-term consequences in infected individuals.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261909
Delpino, María Victoria; Quarleri, Jorge Fabian; Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications; Frontiers Media; Frontiers in Aging; 5; 9-2024; 1-12
2673-6217
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261909
identifier_str_mv Delpino, María Victoria; Quarleri, Jorge Fabian; Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications; Frontiers Media; Frontiers in Aging; 5; 9-2024; 1-12
2673-6217
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fragi.2024.1442323/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fragi.2024.1442323
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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