Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology

Autores
Fuertes, Mariana; Gerez, Juan Atilio; Haedo, Mariana Raquel; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Labeur, Marta; Stalla, Günter K; Arzt, Eduardo Simon
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.
Fil: Fuertes, Mariana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerez, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Páez Pereda, Marcelo. Affectis Pharmaceuticals; Alemania
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
Fil: Stalla, Günter K. Max Planck Institute of Psychiatry; Alemania
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Rsume
Pituitary
Gp130 Cytokines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12635
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12635
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biologyFuertes, MarianaGerez, Juan AtilioHaedo, Mariana RaquelGiacomini, Damiana PaulaPáez Pereda, MarceloLabeur, MartaStalla, Günter KArzt, Eduardo SimonRsumePituitaryGp130 Cytokineshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.Fil: Fuertes, Mariana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gerez, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Páez Pereda, Marcelo. Affectis Pharmaceuticals; AlemaniaFil: Labeur, Marta. Max Planck Institute of Psychiatry; AlemaniaFil: Stalla, Günter K. Max Planck Institute of Psychiatry; AlemaniaFil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaKarger2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12635Fuertes, Mariana; Gerez, Juan Atilio; Haedo, Mariana Raquel; Giacomini, Damiana Paula; Páez Pereda, Marcelo; et al.; Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology; Karger; Frontiers of Hormone Research; 38; 2010; 1-60301-3073enginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/318488info:eu-repo/semantics/altIdentifier/doi/10.1159/000318488info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:41Zoai:ri.conicet.gov.ar:11336/12635instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:42.052CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
spellingShingle Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
Fuertes, Mariana
Rsume
Pituitary
Gp130 Cytokines
title_short Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_full Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_fullStr Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_full_unstemmed Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
title_sort Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
dc.creator.none.fl_str_mv Fuertes, Mariana
Gerez, Juan Atilio
Haedo, Mariana Raquel
Giacomini, Damiana Paula
Páez Pereda, Marcelo
Labeur, Marta
Stalla, Günter K
Arzt, Eduardo Simon
author Fuertes, Mariana
author_facet Fuertes, Mariana
Gerez, Juan Atilio
Haedo, Mariana Raquel
Giacomini, Damiana Paula
Páez Pereda, Marcelo
Labeur, Marta
Stalla, Günter K
Arzt, Eduardo Simon
author_role author
author2 Gerez, Juan Atilio
Haedo, Mariana Raquel
Giacomini, Damiana Paula
Páez Pereda, Marcelo
Labeur, Marta
Stalla, Günter K
Arzt, Eduardo Simon
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Rsume
Pituitary
Gp130 Cytokines
topic Rsume
Pituitary
Gp130 Cytokines
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.
Fil: Fuertes, Mariana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerez, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Páez Pereda, Marcelo. Affectis Pharmaceuticals; Alemania
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
Fil: Stalla, Günter K. Max Planck Institute of Psychiatry; Alemania
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-κB/IκB and HIF-1α pathways). Thus, it could have an important role in the development of the pituitary tumors. Copyright © 2010 S. Karger AG, Basel.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12635
Fuertes, Mariana; Gerez, Juan Atilio; Haedo, Mariana Raquel; Giacomini, Damiana Paula; Páez Pereda, Marcelo; et al.; Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology; Karger; Frontiers of Hormone Research; 38; 2010; 1-6
0301-3073
url http://hdl.handle.net/11336/12635
identifier_str_mv Fuertes, Mariana; Gerez, Juan Atilio; Haedo, Mariana Raquel; Giacomini, Damiana Paula; Páez Pereda, Marcelo; et al.; Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology; Karger; Frontiers of Hormone Research; 38; 2010; 1-6
0301-3073
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/318488
info:eu-repo/semantics/altIdentifier/doi/10.1159/000318488
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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