APP signaling in Alzheimer's disease

Autores
Bignante, Elena Anahi; Lorenzo, Alfredo Guillermo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter of debate, in the last two decades several groups have generated compelling evidence supporting a role of Amyloid β Precursor Protein (APP) as a bona fide receptor for Aβ that can trigger neurodegeneration.
Fil: Bignante, Elena Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Lorenzo, Alfredo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
AMYLOID Β (AΒ)
AMYLOID Β PRECURSOR PROTEIN (APP)
GALLEIN
GO PROTEIN
GΒΓ COMPLEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96883
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96883
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling APP signaling in Alzheimer's diseaseBignante, Elena AnahiLorenzo, Alfredo GuillermoAMYLOID Β (AΒ)AMYLOID Β PRECURSOR PROTEIN (APP)GALLEINGO PROTEINGΒΓ COMPLEXhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter of debate, in the last two decades several groups have generated compelling evidence supporting a role of Amyloid β Precursor Protein (APP) as a bona fide receptor for Aβ that can trigger neurodegeneration.Fil: Bignante, Elena Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Lorenzo, Alfredo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaImpact Journals2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96883Bignante, Elena Anahi; Lorenzo, Alfredo Guillermo; APP signaling in Alzheimer's disease; Impact Journals; Aging; 10; 11; 11-2018; 3063-30641945-4589CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.18632/aging.101641info:eu-repo/semantics/altIdentifier/url/https://www.aging-us.com/article/101641/textinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286822/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:43Zoai:ri.conicet.gov.ar:11336/96883instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:43.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv APP signaling in Alzheimer's disease
title APP signaling in Alzheimer's disease
spellingShingle APP signaling in Alzheimer's disease
Bignante, Elena Anahi
AMYLOID Β (AΒ)
AMYLOID Β PRECURSOR PROTEIN (APP)
GALLEIN
GO PROTEIN
GΒΓ COMPLEX
title_short APP signaling in Alzheimer's disease
title_full APP signaling in Alzheimer's disease
title_fullStr APP signaling in Alzheimer's disease
title_full_unstemmed APP signaling in Alzheimer's disease
title_sort APP signaling in Alzheimer's disease
dc.creator.none.fl_str_mv Bignante, Elena Anahi
Lorenzo, Alfredo Guillermo
author Bignante, Elena Anahi
author_facet Bignante, Elena Anahi
Lorenzo, Alfredo Guillermo
author_role author
author2 Lorenzo, Alfredo Guillermo
author2_role author
dc.subject.none.fl_str_mv AMYLOID Β (AΒ)
AMYLOID Β PRECURSOR PROTEIN (APP)
GALLEIN
GO PROTEIN
GΒΓ COMPLEX
topic AMYLOID Β (AΒ)
AMYLOID Β PRECURSOR PROTEIN (APP)
GALLEIN
GO PROTEIN
GΒΓ COMPLEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter of debate, in the last two decades several groups have generated compelling evidence supporting a role of Amyloid β Precursor Protein (APP) as a bona fide receptor for Aβ that can trigger neurodegeneration.
Fil: Bignante, Elena Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Lorenzo, Alfredo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter of debate, in the last two decades several groups have generated compelling evidence supporting a role of Amyloid β Precursor Protein (APP) as a bona fide receptor for Aβ that can trigger neurodegeneration.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96883
Bignante, Elena Anahi; Lorenzo, Alfredo Guillermo; APP signaling in Alzheimer's disease; Impact Journals; Aging; 10; 11; 11-2018; 3063-3064
1945-4589
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96883
identifier_str_mv Bignante, Elena Anahi; Lorenzo, Alfredo Guillermo; APP signaling in Alzheimer's disease; Impact Journals; Aging; 10; 11; 11-2018; 3063-3064
1945-4589
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.18632/aging.101641
info:eu-repo/semantics/altIdentifier/url/https://www.aging-us.com/article/101641/text
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286822/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614328660000768
score 13.070432

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