Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials

Autores
Samame, Cecilia; Aprahamian, Ivan
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Introduction: A significant percentage of people with bipolar disorder (BD) exhibit conspicuous deficits in everyday functioning, even when appropriately treated and after symptomatic recovery is achieved. Given that cognitive impairment is one of the strongest correlates of socio-occupational outcomes and quality of life in BD, cognitive remediation (CR) has been proposed in recent years as a promising treatment that could help bridge the gap between symptomatic and full functional recovery. The aim of this study was to explore the efficacy of CR in improving executive deficits and functional outcomes in BD patients.Method: PubMed, PsycINFO, and CENTRAL were searched from inception to August 2022. Only randomized controlled trials exploring the effects of CR on cognition or functional adjustment in adult BD patients were eligible. Change-score effect sizes (Hedges’ g) were obtained and combined by means of meta-analytic procedures (PROSPERO, CRD42022306504). Results: Nine studies reporting the results of six independent trials (n = 544) were included. Meta-analytic findings revealed small durable improvements in working memory (g = 0.34; 95% CI = 0.12 to 0.56) and planning (g = 0.30; 95% CI = 0.03 to 0.56). However, no significant effects of CR were observed on functional outcomes at treatment completion or at follow-up assessment. Conclusion: Though CR may produce a modest improvement in some aspects of executive functioning, it has not proven to exert any effect on the functional outcomes of BD patients. The best evidence available does not support the inclusion of CR as recommendation in treatment guidelines.
Fil: Samame, Cecilia. Universidad Católica del Uruguay; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; Argentina
Fil: Aprahamian, Ivan. University Of Groninhen; Países Bajos
25th Annual Conference of the International Society for Bipolar Disorders
Chicago
Estados Unidos
International Society for Bipolar Disorders
Materia
Cognitive remediation
Meta-analysis
Bipolar disorder
Efficacy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/245817
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trialsSamame, CeciliaAprahamian, IvanCognitive remediationMeta-analysisBipolar disorderEfficacyhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Introduction: A significant percentage of people with bipolar disorder (BD) exhibit conspicuous deficits in everyday functioning, even when appropriately treated and after symptomatic recovery is achieved. Given that cognitive impairment is one of the strongest correlates of socio-occupational outcomes and quality of life in BD, cognitive remediation (CR) has been proposed in recent years as a promising treatment that could help bridge the gap between symptomatic and full functional recovery. The aim of this study was to explore the efficacy of CR in improving executive deficits and functional outcomes in BD patients.Method: PubMed, PsycINFO, and CENTRAL were searched from inception to August 2022. Only randomized controlled trials exploring the effects of CR on cognition or functional adjustment in adult BD patients were eligible. Change-score effect sizes (Hedges’ g) were obtained and combined by means of meta-analytic procedures (PROSPERO, CRD42022306504). Results: Nine studies reporting the results of six independent trials (n = 544) were included. Meta-analytic findings revealed small durable improvements in working memory (g = 0.34; 95% CI = 0.12 to 0.56) and planning (g = 0.30; 95% CI = 0.03 to 0.56). However, no significant effects of CR were observed on functional outcomes at treatment completion or at follow-up assessment. Conclusion: Though CR may produce a modest improvement in some aspects of executive functioning, it has not proven to exert any effect on the functional outcomes of BD patients. The best evidence available does not support the inclusion of CR as recommendation in treatment guidelines.Fil: Samame, Cecilia. Universidad Católica del Uruguay; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Aprahamian, Ivan. University Of Groninhen; Países Bajos25th Annual Conference of the International Society for Bipolar DisordersChicagoEstados UnidosInternational Society for Bipolar DisordersWiley2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245817Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials; 25th Annual Conference of the International Society for Bipolar Disorders; Chicago; Estados Unidos; 2023; 107-1071398-56471399-5618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13333info:eu-repo/semantics/altIdentifier/doi/10.1111/bdi.13338Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:07Zoai:ri.conicet.gov.ar:11336/245817instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:07.911CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
title Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
spellingShingle Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
Samame, Cecilia
Cognitive remediation
Meta-analysis
Bipolar disorder
Efficacy
title_short Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
title_full Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
title_fullStr Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
title_full_unstemmed Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
title_sort Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials
dc.creator.none.fl_str_mv Samame, Cecilia
Aprahamian, Ivan
author Samame, Cecilia
author_facet Samame, Cecilia
Aprahamian, Ivan
author_role author
author2 Aprahamian, Ivan
author2_role author
dc.subject.none.fl_str_mv Cognitive remediation
Meta-analysis
Bipolar disorder
Efficacy
topic Cognitive remediation
Meta-analysis
Bipolar disorder
Efficacy
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Introduction: A significant percentage of people with bipolar disorder (BD) exhibit conspicuous deficits in everyday functioning, even when appropriately treated and after symptomatic recovery is achieved. Given that cognitive impairment is one of the strongest correlates of socio-occupational outcomes and quality of life in BD, cognitive remediation (CR) has been proposed in recent years as a promising treatment that could help bridge the gap between symptomatic and full functional recovery. The aim of this study was to explore the efficacy of CR in improving executive deficits and functional outcomes in BD patients.Method: PubMed, PsycINFO, and CENTRAL were searched from inception to August 2022. Only randomized controlled trials exploring the effects of CR on cognition or functional adjustment in adult BD patients were eligible. Change-score effect sizes (Hedges’ g) were obtained and combined by means of meta-analytic procedures (PROSPERO, CRD42022306504). Results: Nine studies reporting the results of six independent trials (n = 544) were included. Meta-analytic findings revealed small durable improvements in working memory (g = 0.34; 95% CI = 0.12 to 0.56) and planning (g = 0.30; 95% CI = 0.03 to 0.56). However, no significant effects of CR were observed on functional outcomes at treatment completion or at follow-up assessment. Conclusion: Though CR may produce a modest improvement in some aspects of executive functioning, it has not proven to exert any effect on the functional outcomes of BD patients. The best evidence available does not support the inclusion of CR as recommendation in treatment guidelines.
Fil: Samame, Cecilia. Universidad Católica del Uruguay; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; Argentina
Fil: Aprahamian, Ivan. University Of Groninhen; Países Bajos
25th Annual Conference of the International Society for Bipolar Disorders
Chicago
Estados Unidos
International Society for Bipolar Disorders
description Introduction: A significant percentage of people with bipolar disorder (BD) exhibit conspicuous deficits in everyday functioning, even when appropriately treated and after symptomatic recovery is achieved. Given that cognitive impairment is one of the strongest correlates of socio-occupational outcomes and quality of life in BD, cognitive remediation (CR) has been proposed in recent years as a promising treatment that could help bridge the gap between symptomatic and full functional recovery. The aim of this study was to explore the efficacy of CR in improving executive deficits and functional outcomes in BD patients.Method: PubMed, PsycINFO, and CENTRAL were searched from inception to August 2022. Only randomized controlled trials exploring the effects of CR on cognition or functional adjustment in adult BD patients were eligible. Change-score effect sizes (Hedges’ g) were obtained and combined by means of meta-analytic procedures (PROSPERO, CRD42022306504). Results: Nine studies reporting the results of six independent trials (n = 544) were included. Meta-analytic findings revealed small durable improvements in working memory (g = 0.34; 95% CI = 0.12 to 0.56) and planning (g = 0.30; 95% CI = 0.03 to 0.56). However, no significant effects of CR were observed on functional outcomes at treatment completion or at follow-up assessment. Conclusion: Though CR may produce a modest improvement in some aspects of executive functioning, it has not proven to exert any effect on the functional outcomes of BD patients. The best evidence available does not support the inclusion of CR as recommendation in treatment guidelines.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Conferencia
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245817
Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials; 25th Annual Conference of the International Society for Bipolar Disorders; Chicago; Estados Unidos; 2023; 107-107
1398-5647
1399-5618
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245817
identifier_str_mv Efficacy of cognitive and functional remediation in bipolar disorder: a meta-analysis of randomized controlled trials; 25th Annual Conference of the International Society for Bipolar Disorders; Chicago; Estados Unidos; 2023; 107-107
1398-5647
1399-5618
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13333
info:eu-repo/semantics/altIdentifier/doi/10.1111/bdi.13338
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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