Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice

Autores
Assef Leitão Lotif, Mara; Rocha Valadas, Lidia Audrey; Bottenberg, Peter; Squassi, Aldo Fabian; Farias Botelho Dantas, Thereza Cristina; Florêncio Passos, Vanara; Rodrigues Neto, Edilson Martins; Medeiros Bandeira, Mary Anne; de França Fonteles, Marta Maria
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). Methods: The dentifrice formulation was developed with calcium carbonate (CaCO3) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). Results: After 12 months of aging, the samples showed TF concentration ranging from 1198.9 26.9 to 1443.6 33.4 ppm F, TSF ranging from 869.6 105.5 to 965.8 149.8 ppm F, and IF ranging from 223.5 14.8 to 269.7 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 73.2 to 1083.1 32.4 ppm F, TSF ranging from 552.3 39.9 to 758.4 141.1 ppm F, and IF ranging from 102.2 4.0 to 174.7 4.9 ppm F. Conclusion: Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.
Fil: Assef Leitão Lotif, Mara. Universidade Federal Do Ceara; Brasil
Fil: Rocha Valadas, Lidia Audrey. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario. Catedra de Odontologia Preventiva y Comunitaria.; Argentina. Universidade Federal Do Ceara; Brasil
Fil: Bottenberg, Peter. Vrije Unviversiteit Brussel; Bélgica
Fil: Squassi, Aldo Fabian. Universidad de Buenos Aires. Rectorado. Instituto de Investigaciones en Salud Pública; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farias Botelho Dantas, Thereza Cristina. Christus University Center; Brasil
Fil: Florêncio Passos, Vanara. Universidade Federal Do Ceara; Brasil
Fil: Rodrigues Neto, Edilson Martins. Universidade Federal Do Ceara; Brasil
Fil: Medeiros Bandeira, Mary Anne. Universidade Federal Do Ceara; Brasil
Fil: de França Fonteles, Marta Maria. Universidade Federal Do Ceara; Brasil
Materia
dental caries
dentifrices
natural products
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279533
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/279533
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fluoride Content, Availability, and Stability in a Propolis‐Based DentifriceAssef Leitão Lotif, MaraRocha Valadas, Lidia AudreyBottenberg, PeterSquassi, Aldo FabianFarias Botelho Dantas, Thereza CristinaFlorêncio Passos, VanaraRodrigues Neto, Edilson MartinsMedeiros Bandeira, Mary Annede França Fonteles, Marta Mariadental cariesdentifricesnatural productshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Purpose: This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). Methods: The dentifrice formulation was developed with calcium carbonate (CaCO3) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). Results: After 12 months of aging, the samples showed TF concentration ranging from 1198.9 26.9 to 1443.6 33.4 ppm F, TSF ranging from 869.6 105.5 to 965.8 149.8 ppm F, and IF ranging from 223.5 14.8 to 269.7 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 73.2 to 1083.1 32.4 ppm F, TSF ranging from 552.3 39.9 to 758.4 141.1 ppm F, and IF ranging from 102.2 4.0 to 174.7 4.9 ppm F. Conclusion: Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.Fil: Assef Leitão Lotif, Mara. Universidade Federal Do Ceara; BrasilFil: Rocha Valadas, Lidia Audrey. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario. Catedra de Odontologia Preventiva y Comunitaria.; Argentina. Universidade Federal Do Ceara; BrasilFil: Bottenberg, Peter. Vrije Unviversiteit Brussel; BélgicaFil: Squassi, Aldo Fabian. Universidad de Buenos Aires. Rectorado. Instituto de Investigaciones en Salud Pública; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Farias Botelho Dantas, Thereza Cristina. Christus University Center; BrasilFil: Florêncio Passos, Vanara. Universidade Federal Do Ceara; BrasilFil: Rodrigues Neto, Edilson Martins. Universidade Federal Do Ceara; BrasilFil: Medeiros Bandeira, Mary Anne. Universidade Federal Do Ceara; BrasilFil: de França Fonteles, Marta Maria. Universidade Federal Do Ceara; BrasilJohn Wiley & Sons2025-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279533Assef Leitão Lotif, Mara; Rocha Valadas, Lidia Audrey; Bottenberg, Peter; Squassi, Aldo Fabian; Farias Botelho Dantas, Thereza Cristina; et al.; Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice; John Wiley & Sons; International Journal of Dentistry; 2025; 1; 4-2025; 1-71687-8736CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/ijod/3414733info:eu-repo/semantics/altIdentifier/doi/10.1155/ijod/3414733info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:24:51Zoai:ri.conicet.gov.ar:11336/279533instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:24:51.385CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
title Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
spellingShingle Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
Assef Leitão Lotif, Mara
dental caries
dentifrices
natural products
title_short Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
title_full Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
title_fullStr Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
title_full_unstemmed Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
title_sort Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice
dc.creator.none.fl_str_mv Assef Leitão Lotif, Mara
Rocha Valadas, Lidia Audrey
Bottenberg, Peter
Squassi, Aldo Fabian
Farias Botelho Dantas, Thereza Cristina
Florêncio Passos, Vanara
Rodrigues Neto, Edilson Martins
Medeiros Bandeira, Mary Anne
de França Fonteles, Marta Maria
author Assef Leitão Lotif, Mara
author_facet Assef Leitão Lotif, Mara
Rocha Valadas, Lidia Audrey
Bottenberg, Peter
Squassi, Aldo Fabian
Farias Botelho Dantas, Thereza Cristina
Florêncio Passos, Vanara
Rodrigues Neto, Edilson Martins
Medeiros Bandeira, Mary Anne
de França Fonteles, Marta Maria
author_role author
author2 Rocha Valadas, Lidia Audrey
Bottenberg, Peter
Squassi, Aldo Fabian
Farias Botelho Dantas, Thereza Cristina
Florêncio Passos, Vanara
Rodrigues Neto, Edilson Martins
Medeiros Bandeira, Mary Anne
de França Fonteles, Marta Maria
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv dental caries
dentifrices
natural products
topic dental caries
dentifrices
natural products
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). Methods: The dentifrice formulation was developed with calcium carbonate (CaCO3) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). Results: After 12 months of aging, the samples showed TF concentration ranging from 1198.9 26.9 to 1443.6 33.4 ppm F, TSF ranging from 869.6 105.5 to 965.8 149.8 ppm F, and IF ranging from 223.5 14.8 to 269.7 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 73.2 to 1083.1 32.4 ppm F, TSF ranging from 552.3 39.9 to 758.4 141.1 ppm F, and IF ranging from 102.2 4.0 to 174.7 4.9 ppm F. Conclusion: Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.
Fil: Assef Leitão Lotif, Mara. Universidade Federal Do Ceara; Brasil
Fil: Rocha Valadas, Lidia Audrey. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario. Catedra de Odontologia Preventiva y Comunitaria.; Argentina. Universidade Federal Do Ceara; Brasil
Fil: Bottenberg, Peter. Vrije Unviversiteit Brussel; Bélgica
Fil: Squassi, Aldo Fabian. Universidad de Buenos Aires. Rectorado. Instituto de Investigaciones en Salud Pública; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farias Botelho Dantas, Thereza Cristina. Christus University Center; Brasil
Fil: Florêncio Passos, Vanara. Universidade Federal Do Ceara; Brasil
Fil: Rodrigues Neto, Edilson Martins. Universidade Federal Do Ceara; Brasil
Fil: Medeiros Bandeira, Mary Anne. Universidade Federal Do Ceara; Brasil
Fil: de França Fonteles, Marta Maria. Universidade Federal Do Ceara; Brasil
description Purpose: This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). Methods: The dentifrice formulation was developed with calcium carbonate (CaCO3) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). Results: After 12 months of aging, the samples showed TF concentration ranging from 1198.9 26.9 to 1443.6 33.4 ppm F, TSF ranging from 869.6 105.5 to 965.8 149.8 ppm F, and IF ranging from 223.5 14.8 to 269.7 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 73.2 to 1083.1 32.4 ppm F, TSF ranging from 552.3 39.9 to 758.4 141.1 ppm F, and IF ranging from 102.2 4.0 to 174.7 4.9 ppm F. Conclusion: Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.
publishDate 2025
dc.date.none.fl_str_mv 2025-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279533
Assef Leitão Lotif, Mara; Rocha Valadas, Lidia Audrey; Bottenberg, Peter; Squassi, Aldo Fabian; Farias Botelho Dantas, Thereza Cristina; et al.; Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice; John Wiley & Sons; International Journal of Dentistry; 2025; 1; 4-2025; 1-7
1687-8736
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279533
identifier_str_mv Assef Leitão Lotif, Mara; Rocha Valadas, Lidia Audrey; Bottenberg, Peter; Squassi, Aldo Fabian; Farias Botelho Dantas, Thereza Cristina; et al.; Fluoride Content, Availability, and Stability in a Propolis‐Based Dentifrice; John Wiley & Sons; International Journal of Dentistry; 2025; 1; 4-2025; 1-7
1687-8736
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/ijod/3414733
info:eu-repo/semantics/altIdentifier/doi/10.1155/ijod/3414733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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