Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications

Autores
Bongiovanni Abel, Silvestre Manuel; Busatto, Carlos Alberto; Karp, Federico; Estenoz, Diana Alejandra; Calderón, Marcelo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Advances in polymer science have led to the development of semi-interpenetrated and interpenetrated networks (SIPN/IPN). The interpenetration procedure allows enhancing several important properties of a polymeric material, including mechanical properties, swelling capability, stimulus-sensitive response, and biological performance, among others. More interestingly, the interpenetration (or semi-interpenetration) can be achieved independent of the material size, that is at the macroscopic, microscopic, or nanometric scale. SIPN/IPN have been used for a wide range of applications, especially in the biomedical field, including tissue engineering, delivery of chemical compounds or biological macromolecules, and multifunctional systems as theragnostic platforms. In the last years, this fascinating field has gained a great interest in the area of polymers for therapeutics; therefore, a comprehensive revision of the topic is timely. In this review, we describe in detail the most relevant synthetic approaches to fabricate polymeric IPN and SIPN, ranging from nanoscale to macroscale. The advantages of typical synthetic methods are analyzed, as well as novel and promising trends in the field of advanced material fabrication. Furthermore, the characterization techniques employed for these materials are summarized from physicochemical, thermal, mechanical, and biological perspectives. The applications of novel (semi-)interpenetrated structures are discussed with a focus on drug delivery, tissue engineering, and regenerative medicine, as well as combinations thereof.
Fil: Bongiovanni Abel, Silvestre Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Universidad del País Vasco. Polymat; España
Fil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Materia
INTERPENETRATED POLYMERIC NETWORKS
HYDROGELS
TISSUE ENGINEERING
DRUG DELIVERY
MULTIFUNCTIONAL PLATFORMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226115
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/226115
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applicationsBongiovanni Abel, Silvestre ManuelBusatto, Carlos AlbertoKarp, FedericoEstenoz, Diana AlejandraCalderón, MarceloINTERPENETRATED POLYMERIC NETWORKSHYDROGELSTISSUE ENGINEERINGDRUG DELIVERYMULTIFUNCTIONAL PLATFORMShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Advances in polymer science have led to the development of semi-interpenetrated and interpenetrated networks (SIPN/IPN). The interpenetration procedure allows enhancing several important properties of a polymeric material, including mechanical properties, swelling capability, stimulus-sensitive response, and biological performance, among others. More interestingly, the interpenetration (or semi-interpenetration) can be achieved independent of the material size, that is at the macroscopic, microscopic, or nanometric scale. SIPN/IPN have been used for a wide range of applications, especially in the biomedical field, including tissue engineering, delivery of chemical compounds or biological macromolecules, and multifunctional systems as theragnostic platforms. In the last years, this fascinating field has gained a great interest in the area of polymers for therapeutics; therefore, a comprehensive revision of the topic is timely. In this review, we describe in detail the most relevant synthetic approaches to fabricate polymeric IPN and SIPN, ranging from nanoscale to macroscale. The advantages of typical synthetic methods are analyzed, as well as novel and promising trends in the field of advanced material fabrication. Furthermore, the characterization techniques employed for these materials are summarized from physicochemical, thermal, mechanical, and biological perspectives. The applications of novel (semi-)interpenetrated structures are discussed with a focus on drug delivery, tissue engineering, and regenerative medicine, as well as combinations thereof.Fil: Bongiovanni Abel, Silvestre Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Universidad del País Vasco. Polymat; EspañaFil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; EspañaElsevier Science2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226115Bongiovanni Abel, Silvestre Manuel; Busatto, Carlos Alberto; Karp, Federico; Estenoz, Diana Alejandra; Calderón, Marcelo; Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications; Elsevier Science; Advances In Colloid And Interface Science; 321; 103026; 11-2023; 1-480001-8686CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0001868623001938info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cis.2023.103026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:52Zoai:ri.conicet.gov.ar:11336/226115instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:52.475CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
title Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
spellingShingle Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
Bongiovanni Abel, Silvestre Manuel
INTERPENETRATED POLYMERIC NETWORKS
HYDROGELS
TISSUE ENGINEERING
DRUG DELIVERY
MULTIFUNCTIONAL PLATFORMS
title_short Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
title_full Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
title_fullStr Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
title_full_unstemmed Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
title_sort Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications
dc.creator.none.fl_str_mv Bongiovanni Abel, Silvestre Manuel
Busatto, Carlos Alberto
Karp, Federico
Estenoz, Diana Alejandra
Calderón, Marcelo
author Bongiovanni Abel, Silvestre Manuel
author_facet Bongiovanni Abel, Silvestre Manuel
Busatto, Carlos Alberto
Karp, Federico
Estenoz, Diana Alejandra
Calderón, Marcelo
author_role author
author2 Busatto, Carlos Alberto
Karp, Federico
Estenoz, Diana Alejandra
Calderón, Marcelo
author2_role author
author
author
author
dc.subject.none.fl_str_mv INTERPENETRATED POLYMERIC NETWORKS
HYDROGELS
TISSUE ENGINEERING
DRUG DELIVERY
MULTIFUNCTIONAL PLATFORMS
topic INTERPENETRATED POLYMERIC NETWORKS
HYDROGELS
TISSUE ENGINEERING
DRUG DELIVERY
MULTIFUNCTIONAL PLATFORMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Advances in polymer science have led to the development of semi-interpenetrated and interpenetrated networks (SIPN/IPN). The interpenetration procedure allows enhancing several important properties of a polymeric material, including mechanical properties, swelling capability, stimulus-sensitive response, and biological performance, among others. More interestingly, the interpenetration (or semi-interpenetration) can be achieved independent of the material size, that is at the macroscopic, microscopic, or nanometric scale. SIPN/IPN have been used for a wide range of applications, especially in the biomedical field, including tissue engineering, delivery of chemical compounds or biological macromolecules, and multifunctional systems as theragnostic platforms. In the last years, this fascinating field has gained a great interest in the area of polymers for therapeutics; therefore, a comprehensive revision of the topic is timely. In this review, we describe in detail the most relevant synthetic approaches to fabricate polymeric IPN and SIPN, ranging from nanoscale to macroscale. The advantages of typical synthetic methods are analyzed, as well as novel and promising trends in the field of advanced material fabrication. Furthermore, the characterization techniques employed for these materials are summarized from physicochemical, thermal, mechanical, and biological perspectives. The applications of novel (semi-)interpenetrated structures are discussed with a focus on drug delivery, tissue engineering, and regenerative medicine, as well as combinations thereof.
Fil: Bongiovanni Abel, Silvestre Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Universidad del País Vasco. Polymat; España
Fil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
description Advances in polymer science have led to the development of semi-interpenetrated and interpenetrated networks (SIPN/IPN). The interpenetration procedure allows enhancing several important properties of a polymeric material, including mechanical properties, swelling capability, stimulus-sensitive response, and biological performance, among others. More interestingly, the interpenetration (or semi-interpenetration) can be achieved independent of the material size, that is at the macroscopic, microscopic, or nanometric scale. SIPN/IPN have been used for a wide range of applications, especially in the biomedical field, including tissue engineering, delivery of chemical compounds or biological macromolecules, and multifunctional systems as theragnostic platforms. In the last years, this fascinating field has gained a great interest in the area of polymers for therapeutics; therefore, a comprehensive revision of the topic is timely. In this review, we describe in detail the most relevant synthetic approaches to fabricate polymeric IPN and SIPN, ranging from nanoscale to macroscale. The advantages of typical synthetic methods are analyzed, as well as novel and promising trends in the field of advanced material fabrication. Furthermore, the characterization techniques employed for these materials are summarized from physicochemical, thermal, mechanical, and biological perspectives. The applications of novel (semi-)interpenetrated structures are discussed with a focus on drug delivery, tissue engineering, and regenerative medicine, as well as combinations thereof.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226115
Bongiovanni Abel, Silvestre Manuel; Busatto, Carlos Alberto; Karp, Federico; Estenoz, Diana Alejandra; Calderón, Marcelo; Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications; Elsevier Science; Advances In Colloid And Interface Science; 321; 103026; 11-2023; 1-48
0001-8686
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226115
identifier_str_mv Bongiovanni Abel, Silvestre Manuel; Busatto, Carlos Alberto; Karp, Federico; Estenoz, Diana Alejandra; Calderón, Marcelo; Weaving the next generation of (bio)materials: Semi-interpenetrated and interpenetrated polymeric networks for biomedical applications; Elsevier Science; Advances In Colloid And Interface Science; 321; 103026; 11-2023; 1-48
0001-8686
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0001868623001938
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cis.2023.103026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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