Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus

Autores
Santander, Odra; Arredondo, Sebastián B.; García Rojas, Francisca; Estay, Sebastián F.; Belforte, Juan Emilio; Chávez, Andrés E.; Varela Nallar, Lorena; Fuenzalida, Marco
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integration in the hippocampus a brain region critical for cognition remains unclear. Using functional and molecular analyses, we found that chronic ketamine administration during adolescence exerts long-term effects on synaptic integration, expanding the temporal window in an input-specific manner affecting the inner molecular layer but not the medial perforant path inputs in the adult mouse dorsal hippocampal dentate gyrus. Ketamine also alters the excitatory/inhibitory balance by reducing the efficacy of inhibitory inputs likely due to a reduction in parvalbumin-positive interneurons number and function. These findings indicate that during adolescence, ketamine exerts a strong effect on inhibitory synaptic function mediated by parvalbumin-positive neurons that ultimately impact synaptic integration in the dorsal adult dentate gyrus, which could help to understand the neurobiological and functional bases that confer greater vulnerability to the adolescent brain.
Fil: Santander, Odra. Universidad de Valparaíso; Chile
Fil: Arredondo, Sebastián B.. Universidad Andrés Bello; Chile
Fil: García Rojas, Francisca. Universidad de Valparaíso; Chile
Fil: Estay, Sebastián F.. Universidad de Valparaíso; Chile
Fil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Chávez, Andrés E.. Universidad de Valparaíso; Chile
Fil: Varela Nallar, Lorena. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; Chile
Fil: Fuenzalida, Marco. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; Chile
Materia
Ketamina
Interneuronas
Plasticidad
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280029
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrusSantander, OdraArredondo, Sebastián B.García Rojas, FranciscaEstay, Sebastián F.Belforte, Juan EmilioChávez, Andrés E.Varela Nallar, LorenaFuenzalida, MarcoKetaminaInterneuronasPlasticidadhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integration in the hippocampus a brain region critical for cognition remains unclear. Using functional and molecular analyses, we found that chronic ketamine administration during adolescence exerts long-term effects on synaptic integration, expanding the temporal window in an input-specific manner affecting the inner molecular layer but not the medial perforant path inputs in the adult mouse dorsal hippocampal dentate gyrus. Ketamine also alters the excitatory/inhibitory balance by reducing the efficacy of inhibitory inputs likely due to a reduction in parvalbumin-positive interneurons number and function. These findings indicate that during adolescence, ketamine exerts a strong effect on inhibitory synaptic function mediated by parvalbumin-positive neurons that ultimately impact synaptic integration in the dorsal adult dentate gyrus, which could help to understand the neurobiological and functional bases that confer greater vulnerability to the adolescent brain.Fil: Santander, Odra. Universidad de Valparaíso; ChileFil: Arredondo, Sebastián B.. Universidad Andrés Bello; ChileFil: García Rojas, Francisca. Universidad de Valparaíso; ChileFil: Estay, Sebastián F.. Universidad de Valparaíso; ChileFil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Chávez, Andrés E.. Universidad de Valparaíso; ChileFil: Varela Nallar, Lorena. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; ChileFil: Fuenzalida, Marco. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; ChilePergamon-Elsevier Science Ltd2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280029Santander, Odra; Arredondo, Sebastián B.; García Rojas, Francisca; Estay, Sebastián F.; Belforte, Juan Emilio; et al.; Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 246; 102718; 3-2025; 1-250301-0082CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0301008225000097info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2025.102718info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:09:38Zoai:ri.conicet.gov.ar:11336/280029instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:09:39.156CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
title Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
spellingShingle Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
Santander, Odra
Ketamina
Interneuronas
Plasticidad
title_short Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
title_full Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
title_fullStr Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
title_full_unstemmed Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
title_sort Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus
dc.creator.none.fl_str_mv Santander, Odra
Arredondo, Sebastián B.
García Rojas, Francisca
Estay, Sebastián F.
Belforte, Juan Emilio
Chávez, Andrés E.
Varela Nallar, Lorena
Fuenzalida, Marco
author Santander, Odra
author_facet Santander, Odra
Arredondo, Sebastián B.
García Rojas, Francisca
Estay, Sebastián F.
Belforte, Juan Emilio
Chávez, Andrés E.
Varela Nallar, Lorena
Fuenzalida, Marco
author_role author
author2 Arredondo, Sebastián B.
García Rojas, Francisca
Estay, Sebastián F.
Belforte, Juan Emilio
Chávez, Andrés E.
Varela Nallar, Lorena
Fuenzalida, Marco
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ketamina
Interneuronas
Plasticidad
topic Ketamina
Interneuronas
Plasticidad
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integration in the hippocampus a brain region critical for cognition remains unclear. Using functional and molecular analyses, we found that chronic ketamine administration during adolescence exerts long-term effects on synaptic integration, expanding the temporal window in an input-specific manner affecting the inner molecular layer but not the medial perforant path inputs in the adult mouse dorsal hippocampal dentate gyrus. Ketamine also alters the excitatory/inhibitory balance by reducing the efficacy of inhibitory inputs likely due to a reduction in parvalbumin-positive interneurons number and function. These findings indicate that during adolescence, ketamine exerts a strong effect on inhibitory synaptic function mediated by parvalbumin-positive neurons that ultimately impact synaptic integration in the dorsal adult dentate gyrus, which could help to understand the neurobiological and functional bases that confer greater vulnerability to the adolescent brain.
Fil: Santander, Odra. Universidad de Valparaíso; Chile
Fil: Arredondo, Sebastián B.. Universidad Andrés Bello; Chile
Fil: García Rojas, Francisca. Universidad de Valparaíso; Chile
Fil: Estay, Sebastián F.. Universidad de Valparaíso; Chile
Fil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Chávez, Andrés E.. Universidad de Valparaíso; Chile
Fil: Varela Nallar, Lorena. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; Chile
Fil: Fuenzalida, Marco. Universidad de Valparaíso; Chile. Millennium Nucleus of Neuroepigenetics and Plasticity; Chile
description Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integration in the hippocampus a brain region critical for cognition remains unclear. Using functional and molecular analyses, we found that chronic ketamine administration during adolescence exerts long-term effects on synaptic integration, expanding the temporal window in an input-specific manner affecting the inner molecular layer but not the medial perforant path inputs in the adult mouse dorsal hippocampal dentate gyrus. Ketamine also alters the excitatory/inhibitory balance by reducing the efficacy of inhibitory inputs likely due to a reduction in parvalbumin-positive interneurons number and function. These findings indicate that during adolescence, ketamine exerts a strong effect on inhibitory synaptic function mediated by parvalbumin-positive neurons that ultimately impact synaptic integration in the dorsal adult dentate gyrus, which could help to understand the neurobiological and functional bases that confer greater vulnerability to the adolescent brain.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280029
Santander, Odra; Arredondo, Sebastián B.; García Rojas, Francisca; Estay, Sebastián F.; Belforte, Juan Emilio; et al.; Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 246; 102718; 3-2025; 1-25
0301-0082
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280029
identifier_str_mv Santander, Odra; Arredondo, Sebastián B.; García Rojas, Francisca; Estay, Sebastián F.; Belforte, Juan Emilio; et al.; Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 246; 102718; 3-2025; 1-25
0301-0082
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0301008225000097
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2025.102718
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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