Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study

Autores
Daier, Veronica Andrea; Rivière, Eric; Mallet Ladeira, Sonia; Moreno, Diego Martin; Hureau, C; Signorella, Sandra Rosanna
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two imidazolate-bridged diCuII and CuIIZnII complexes, [CuZn(dien)2(μ-Im)](ClO4)3·MeOH (1) and [Cu2(dien)2(μ-Im)](ClO4)3 (2) (Im = imidazole, dien = diethylenetriamine), and two complexes formed with Schiff base ligands, [CuZn(salpn)Cl2] (3) and [Cu2(salbutO)ClO4] (4) (H2salpn = 1,3-bis(salicylidenamino)propane, H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol) have been prepared and characterized. The reaction of [Cu(dien)(ImH)](ClO4)2 with [Zn(dien)(H2O)](ClO4)2 at pH ≥ 11 yields complex 1; at lower pH, the Cu3Zn tetranuclear complex [{(dien)Cu(μ-Im)}3Zn(OH2)(ClO4)2](ClO4)3 (1a) forms as the main reaction product. X-ray diffraction of 1a reveals that the complex contains a metal centered windmill-shaped cation having three blades with a central Zn ion and three peripheral capping Cu(dien) moieties bound to the central Zn ion through three imidazolate bridges. The four complexes are able to disproportionate O2− in aqueous medium at pH 7.8, with relative rates 4 > 1 > 2 ≫ 3. [Cu2(salbutO)]+ (4) is the most easily reducible of the four complexes and exhibits the highest activity among the SOD models reported so far; a fact related to the ligand flexibility to accommodate the copper ion in both CuI and CuII oxidation states and the lability of the fourth coordination position of copper facilitating stereochemical rearrangements.
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Rivière, Eric. Université Paris Sud; Francia. Centre National de la Recherche Scientifique; Francia. Universite de Paris XI. Institut de Chimie Moléculaire et des Matériaux d'Orsay; Francia
Fil: Mallet Ladeira, Sonia. Université Paul Sabatier; Francia
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Hureau, C. Université Paul Sabatier; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
Cu/Zn Complexes
Sod Activity
Stability
Structure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52716
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/52716
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative studyDaier, Veronica AndreaRivière, EricMallet Ladeira, SoniaMoreno, Diego MartinHureau, CSignorella, Sandra RosannaCu/Zn ComplexesSod ActivityStabilityStructurehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two imidazolate-bridged diCuII and CuIIZnII complexes, [CuZn(dien)2(μ-Im)](ClO4)3·MeOH (1) and [Cu2(dien)2(μ-Im)](ClO4)3 (2) (Im = imidazole, dien = diethylenetriamine), and two complexes formed with Schiff base ligands, [CuZn(salpn)Cl2] (3) and [Cu2(salbutO)ClO4] (4) (H2salpn = 1,3-bis(salicylidenamino)propane, H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol) have been prepared and characterized. The reaction of [Cu(dien)(ImH)](ClO4)2 with [Zn(dien)(H2O)](ClO4)2 at pH ≥ 11 yields complex 1; at lower pH, the Cu3Zn tetranuclear complex [{(dien)Cu(μ-Im)}3Zn(OH2)(ClO4)2](ClO4)3 (1a) forms as the main reaction product. X-ray diffraction of 1a reveals that the complex contains a metal centered windmill-shaped cation having three blades with a central Zn ion and three peripheral capping Cu(dien) moieties bound to the central Zn ion through three imidazolate bridges. The four complexes are able to disproportionate O2− in aqueous medium at pH 7.8, with relative rates 4 > 1 > 2 ≫ 3. [Cu2(salbutO)]+ (4) is the most easily reducible of the four complexes and exhibits the highest activity among the SOD models reported so far; a fact related to the ligand flexibility to accommodate the copper ion in both CuI and CuII oxidation states and the lability of the fourth coordination position of copper facilitating stereochemical rearrangements.Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Rivière, Eric. Université Paris Sud; Francia. Centre National de la Recherche Scientifique; Francia. Universite de Paris XI. Institut de Chimie Moléculaire et des Matériaux d'Orsay; FranciaFil: Mallet Ladeira, Sonia. Université Paul Sabatier; FranciaFil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Hureau, C. Université Paul Sabatier; Francia. Centre National de la Recherche Scientifique; FranciaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaElsevier Science Inc2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52716Daier, Veronica Andrea; Rivière, Eric; Mallet Ladeira, Sonia; Moreno, Diego Martin; Hureau, C; et al.; Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study; Elsevier Science Inc; Journal of Inorganic Biochemistry; 163; 10-2016; 162-1750162-0134CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2016.07.008info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016201341630201Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:08Zoai:ri.conicet.gov.ar:11336/52716instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:08.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
title Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
spellingShingle Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
Daier, Veronica Andrea
Cu/Zn Complexes
Sod Activity
Stability
Structure
title_short Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
title_full Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
title_fullStr Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
title_full_unstemmed Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
title_sort Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
dc.creator.none.fl_str_mv Daier, Veronica Andrea
Rivière, Eric
Mallet Ladeira, Sonia
Moreno, Diego Martin
Hureau, C
Signorella, Sandra Rosanna
author Daier, Veronica Andrea
author_facet Daier, Veronica Andrea
Rivière, Eric
Mallet Ladeira, Sonia
Moreno, Diego Martin
Hureau, C
Signorella, Sandra Rosanna
author_role author
author2 Rivière, Eric
Mallet Ladeira, Sonia
Moreno, Diego Martin
Hureau, C
Signorella, Sandra Rosanna
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cu/Zn Complexes
Sod Activity
Stability
Structure
topic Cu/Zn Complexes
Sod Activity
Stability
Structure
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two imidazolate-bridged diCuII and CuIIZnII complexes, [CuZn(dien)2(μ-Im)](ClO4)3·MeOH (1) and [Cu2(dien)2(μ-Im)](ClO4)3 (2) (Im = imidazole, dien = diethylenetriamine), and two complexes formed with Schiff base ligands, [CuZn(salpn)Cl2] (3) and [Cu2(salbutO)ClO4] (4) (H2salpn = 1,3-bis(salicylidenamino)propane, H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol) have been prepared and characterized. The reaction of [Cu(dien)(ImH)](ClO4)2 with [Zn(dien)(H2O)](ClO4)2 at pH ≥ 11 yields complex 1; at lower pH, the Cu3Zn tetranuclear complex [{(dien)Cu(μ-Im)}3Zn(OH2)(ClO4)2](ClO4)3 (1a) forms as the main reaction product. X-ray diffraction of 1a reveals that the complex contains a metal centered windmill-shaped cation having three blades with a central Zn ion and three peripheral capping Cu(dien) moieties bound to the central Zn ion through three imidazolate bridges. The four complexes are able to disproportionate O2− in aqueous medium at pH 7.8, with relative rates 4 > 1 > 2 ≫ 3. [Cu2(salbutO)]+ (4) is the most easily reducible of the four complexes and exhibits the highest activity among the SOD models reported so far; a fact related to the ligand flexibility to accommodate the copper ion in both CuI and CuII oxidation states and the lability of the fourth coordination position of copper facilitating stereochemical rearrangements.
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Rivière, Eric. Université Paris Sud; Francia. Centre National de la Recherche Scientifique; Francia. Universite de Paris XI. Institut de Chimie Moléculaire et des Matériaux d'Orsay; Francia
Fil: Mallet Ladeira, Sonia. Université Paul Sabatier; Francia
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Hureau, C. Université Paul Sabatier; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description Two imidazolate-bridged diCuII and CuIIZnII complexes, [CuZn(dien)2(μ-Im)](ClO4)3·MeOH (1) and [Cu2(dien)2(μ-Im)](ClO4)3 (2) (Im = imidazole, dien = diethylenetriamine), and two complexes formed with Schiff base ligands, [CuZn(salpn)Cl2] (3) and [Cu2(salbutO)ClO4] (4) (H2salpn = 1,3-bis(salicylidenamino)propane, H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol) have been prepared and characterized. The reaction of [Cu(dien)(ImH)](ClO4)2 with [Zn(dien)(H2O)](ClO4)2 at pH ≥ 11 yields complex 1; at lower pH, the Cu3Zn tetranuclear complex [{(dien)Cu(μ-Im)}3Zn(OH2)(ClO4)2](ClO4)3 (1a) forms as the main reaction product. X-ray diffraction of 1a reveals that the complex contains a metal centered windmill-shaped cation having three blades with a central Zn ion and three peripheral capping Cu(dien) moieties bound to the central Zn ion through three imidazolate bridges. The four complexes are able to disproportionate O2− in aqueous medium at pH 7.8, with relative rates 4 > 1 > 2 ≫ 3. [Cu2(salbutO)]+ (4) is the most easily reducible of the four complexes and exhibits the highest activity among the SOD models reported so far; a fact related to the ligand flexibility to accommodate the copper ion in both CuI and CuII oxidation states and the lability of the fourth coordination position of copper facilitating stereochemical rearrangements.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52716
Daier, Veronica Andrea; Rivière, Eric; Mallet Ladeira, Sonia; Moreno, Diego Martin; Hureau, C; et al.; Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study; Elsevier Science Inc; Journal of Inorganic Biochemistry; 163; 10-2016; 162-175
0162-0134
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52716
identifier_str_mv Daier, Veronica Andrea; Rivière, Eric; Mallet Ladeira, Sonia; Moreno, Diego Martin; Hureau, C; et al.; Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study; Elsevier Science Inc; Journal of Inorganic Biochemistry; 163; 10-2016; 162-175
0162-0134
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2016.07.008
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016201341630201X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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