Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone

Autores
Álvarez Lloret, Pedro; Benavides Reyes, Cristina; Lee, Ching Ming; Martínez, María Pilar; Conti, Maria Ines; Rodríguez Navarro, Alejandro B.; González López, Santiago; Perez Huerta, Alberto; Terrizzi, Antonela Romina
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of the present study was to investigate the effects of chronic lead exposure on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated with sodium acetate. The alveolar bone structure and chemical composition of the dissected mandibles were examined using micro-computed tomography (micro-CT), scanning electron microscopy (SEM), inductively coupled plasma optical emission spectrometry (ICP-OES), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray diffraction (XRD) techniques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes in bone mechanical properties were analysed using a three-point bending test. Exposure to lead induced notable changes in bone mineralization and properties, specifically a reduction of the trabecular thickness and bone mineral density. Furthermore, there was a reduction in carbonate content and an increase in bone mineral crystallinity. These changes in bone mineralization could be explained by an alteration in bone turnover due to lead exposure. Three-point bending showed a trend of decreased displacement at failure in the mandibles of lead-exposed rats, which could compromise the mechanical stability and normal development of the dentition.
Fil: Álvarez Lloret, Pedro. Universidad de Oviedo; España
Fil: Benavides Reyes, Cristina. Universidad de Granada; España
Fil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Martínez, María Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Rodríguez Navarro, Alejandro B.. Universidad de Granada; España
Fil: González López, Santiago. Universidad de Granada; España
Fil: Perez Huerta, Alberto. University of Alabama; Estados Unidos
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
LEAD INTOXICATION
BONE MINERALIZATION
MANDIBULAR BONE
MECHANICAL PROPERTIES
APATITE CRYSTALLINITY
TRABECULAR MORPHOLOGY
ALVEOLAR PROCESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156822
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/156822
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic Lead Exposure Alters Mineral Properties in Alveolar BoneÁlvarez Lloret, PedroBenavides Reyes, CristinaLee, Ching MingMartínez, María PilarConti, Maria InesRodríguez Navarro, Alejandro B.González López, SantiagoPerez Huerta, AlbertoTerrizzi, Antonela RominaLEAD INTOXICATIONBONE MINERALIZATIONMANDIBULAR BONEMECHANICAL PROPERTIESAPATITE CRYSTALLINITYTRABECULAR MORPHOLOGYALVEOLAR PROCESShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The objective of the present study was to investigate the effects of chronic lead exposure on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated with sodium acetate. The alveolar bone structure and chemical composition of the dissected mandibles were examined using micro-computed tomography (micro-CT), scanning electron microscopy (SEM), inductively coupled plasma optical emission spectrometry (ICP-OES), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray diffraction (XRD) techniques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes in bone mechanical properties were analysed using a three-point bending test. Exposure to lead induced notable changes in bone mineralization and properties, specifically a reduction of the trabecular thickness and bone mineral density. Furthermore, there was a reduction in carbonate content and an increase in bone mineral crystallinity. These changes in bone mineralization could be explained by an alteration in bone turnover due to lead exposure. Three-point bending showed a trend of decreased displacement at failure in the mandibles of lead-exposed rats, which could compromise the mechanical stability and normal development of the dentition.Fil: Álvarez Lloret, Pedro. Universidad de Oviedo; EspañaFil: Benavides Reyes, Cristina. Universidad de Granada; EspañaFil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Martínez, María Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Rodríguez Navarro, Alejandro B.. Universidad de Granada; EspañaFil: González López, Santiago. Universidad de Granada; EspañaFil: Perez Huerta, Alberto. University of Alabama; Estados UnidosFil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaMDPI2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156822Álvarez Lloret, Pedro; Benavides Reyes, Cristina; Lee, Ching Ming; Martínez, María Pilar; Conti, Maria Ines; et al.; Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone; MDPI; Minerals; 11; 6; 6-2021; 1-122075-163X2075-163XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2075-163X/11/6/642info:eu-repo/semantics/altIdentifier/doi/10.3390/min11060642info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:51Zoai:ri.conicet.gov.ar:11336/156822instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:51.445CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
title Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
spellingShingle Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
Álvarez Lloret, Pedro
LEAD INTOXICATION
BONE MINERALIZATION
MANDIBULAR BONE
MECHANICAL PROPERTIES
APATITE CRYSTALLINITY
TRABECULAR MORPHOLOGY
ALVEOLAR PROCESS
title_short Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
title_full Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
title_fullStr Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
title_full_unstemmed Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
title_sort Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone
dc.creator.none.fl_str_mv Álvarez Lloret, Pedro
Benavides Reyes, Cristina
Lee, Ching Ming
Martínez, María Pilar
Conti, Maria Ines
Rodríguez Navarro, Alejandro B.
González López, Santiago
Perez Huerta, Alberto
Terrizzi, Antonela Romina
author Álvarez Lloret, Pedro
author_facet Álvarez Lloret, Pedro
Benavides Reyes, Cristina
Lee, Ching Ming
Martínez, María Pilar
Conti, Maria Ines
Rodríguez Navarro, Alejandro B.
González López, Santiago
Perez Huerta, Alberto
Terrizzi, Antonela Romina
author_role author
author2 Benavides Reyes, Cristina
Lee, Ching Ming
Martínez, María Pilar
Conti, Maria Ines
Rodríguez Navarro, Alejandro B.
González López, Santiago
Perez Huerta, Alberto
Terrizzi, Antonela Romina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LEAD INTOXICATION
BONE MINERALIZATION
MANDIBULAR BONE
MECHANICAL PROPERTIES
APATITE CRYSTALLINITY
TRABECULAR MORPHOLOGY
ALVEOLAR PROCESS
topic LEAD INTOXICATION
BONE MINERALIZATION
MANDIBULAR BONE
MECHANICAL PROPERTIES
APATITE CRYSTALLINITY
TRABECULAR MORPHOLOGY
ALVEOLAR PROCESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The objective of the present study was to investigate the effects of chronic lead exposure on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated with sodium acetate. The alveolar bone structure and chemical composition of the dissected mandibles were examined using micro-computed tomography (micro-CT), scanning electron microscopy (SEM), inductively coupled plasma optical emission spectrometry (ICP-OES), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray diffraction (XRD) techniques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes in bone mechanical properties were analysed using a three-point bending test. Exposure to lead induced notable changes in bone mineralization and properties, specifically a reduction of the trabecular thickness and bone mineral density. Furthermore, there was a reduction in carbonate content and an increase in bone mineral crystallinity. These changes in bone mineralization could be explained by an alteration in bone turnover due to lead exposure. Three-point bending showed a trend of decreased displacement at failure in the mandibles of lead-exposed rats, which could compromise the mechanical stability and normal development of the dentition.
Fil: Álvarez Lloret, Pedro. Universidad de Oviedo; España
Fil: Benavides Reyes, Cristina. Universidad de Granada; España
Fil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Martínez, María Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Rodríguez Navarro, Alejandro B.. Universidad de Granada; España
Fil: González López, Santiago. Universidad de Granada; España
Fil: Perez Huerta, Alberto. University of Alabama; Estados Unidos
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description The objective of the present study was to investigate the effects of chronic lead exposure on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated with sodium acetate. The alveolar bone structure and chemical composition of the dissected mandibles were examined using micro-computed tomography (micro-CT), scanning electron microscopy (SEM), inductively coupled plasma optical emission spectrometry (ICP-OES), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray diffraction (XRD) techniques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes in bone mechanical properties were analysed using a three-point bending test. Exposure to lead induced notable changes in bone mineralization and properties, specifically a reduction of the trabecular thickness and bone mineral density. Furthermore, there was a reduction in carbonate content and an increase in bone mineral crystallinity. These changes in bone mineralization could be explained by an alteration in bone turnover due to lead exposure. Three-point bending showed a trend of decreased displacement at failure in the mandibles of lead-exposed rats, which could compromise the mechanical stability and normal development of the dentition.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156822
Álvarez Lloret, Pedro; Benavides Reyes, Cristina; Lee, Ching Ming; Martínez, María Pilar; Conti, Maria Ines; et al.; Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone; MDPI; Minerals; 11; 6; 6-2021; 1-12
2075-163X
2075-163X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156822
identifier_str_mv Álvarez Lloret, Pedro; Benavides Reyes, Cristina; Lee, Ching Ming; Martínez, María Pilar; Conti, Maria Ines; et al.; Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone; MDPI; Minerals; 11; 6; 6-2021; 1-12
2075-163X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2075-163X/11/6/642
info:eu-repo/semantics/altIdentifier/doi/10.3390/min11060642
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269879765303296
score 12.885934

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