Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase

Autores
Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto; Koenitzer, Jeffrey R.; Stewart, Nicolas A.; Wakabayashi, Nobunao; Kensler, Thomas W.; Freeman, Bruce A.; Schopfer, Francisco J.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
Fil: Vitturi, Dario A.. University of Pittsburgh; Estados Unidos
Fil: Chen, Chen Shan. University of Pittsburgh; Estados Unidos
Fil: Woodcock, Steven R.. University of Pittsburgh; Estados Unidos
Fil: Salvatore, Sonia R.. University of Pittsburgh; Estados Unidos
Fil: Bonacci, Gustavo Roberto. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Koenitzer, Jeffrey R.. University of Pittsburgh; Estados Unidos
Fil: Stewart, Nicolas A.. University of Pittsburgh; Estados Unidos
Fil: Wakabayashi, Nobunao. University of Pittsburgh; Estados Unidos
Fil: Kensler, Thomas W.. University of Pittsburgh; Estados Unidos
Fil: Freeman, Bruce A.. University of Pittsburgh; Estados Unidos
Fil: Schopfer, Francisco J.. University of Pittsburgh; Estados Unidos
Materia
EICOSANOID-SPECIFIC ENZYMES
ELECTROPHILE
NITRO-FATTY ACID
REDOX SIGNALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26046
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/26046
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductaseVitturi, Dario A.Chen, Chen ShanWoodcock, Steven R.Salvatore, Sonia R.Bonacci, Gustavo RobertoKoenitzer, Jeffrey R.Stewart, Nicolas A.Wakabayashi, NobunaoKensler, Thomas W.Freeman, Bruce A.Schopfer, Francisco J.EICOSANOID-SPECIFIC ENZYMESELECTROPHILENITRO-FATTY ACIDREDOX SIGNALINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.Fil: Vitturi, Dario A.. University of Pittsburgh; Estados UnidosFil: Chen, Chen Shan. University of Pittsburgh; Estados UnidosFil: Woodcock, Steven R.. University of Pittsburgh; Estados UnidosFil: Salvatore, Sonia R.. University of Pittsburgh; Estados UnidosFil: Bonacci, Gustavo Roberto. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Koenitzer, Jeffrey R.. University of Pittsburgh; Estados UnidosFil: Stewart, Nicolas A.. University of Pittsburgh; Estados UnidosFil: Wakabayashi, Nobunao. University of Pittsburgh; Estados UnidosFil: Kensler, Thomas W.. University of Pittsburgh; Estados UnidosFil: Freeman, Bruce A.. University of Pittsburgh; Estados UnidosFil: Schopfer, Francisco J.. University of Pittsburgh; Estados UnidosAmerican Society for Biochemistry and Molecular Biology2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26046Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto; et al.; Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 288; 35; 8-2013; 25626-256370021-9258CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M113.486282info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/288/35/25626info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757223/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:05Zoai:ri.conicet.gov.ar:11336/26046instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:05.72CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
title Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
spellingShingle Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
Vitturi, Dario A.
EICOSANOID-SPECIFIC ENZYMES
ELECTROPHILE
NITRO-FATTY ACID
REDOX SIGNALING
title_short Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
title_full Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
title_fullStr Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
title_full_unstemmed Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
title_sort Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
dc.creator.none.fl_str_mv Vitturi, Dario A.
Chen, Chen Shan
Woodcock, Steven R.
Salvatore, Sonia R.
Bonacci, Gustavo Roberto
Koenitzer, Jeffrey R.
Stewart, Nicolas A.
Wakabayashi, Nobunao
Kensler, Thomas W.
Freeman, Bruce A.
Schopfer, Francisco J.
author Vitturi, Dario A.
author_facet Vitturi, Dario A.
Chen, Chen Shan
Woodcock, Steven R.
Salvatore, Sonia R.
Bonacci, Gustavo Roberto
Koenitzer, Jeffrey R.
Stewart, Nicolas A.
Wakabayashi, Nobunao
Kensler, Thomas W.
Freeman, Bruce A.
Schopfer, Francisco J.
author_role author
author2 Chen, Chen Shan
Woodcock, Steven R.
Salvatore, Sonia R.
Bonacci, Gustavo Roberto
Koenitzer, Jeffrey R.
Stewart, Nicolas A.
Wakabayashi, Nobunao
Kensler, Thomas W.
Freeman, Bruce A.
Schopfer, Francisco J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EICOSANOID-SPECIFIC ENZYMES
ELECTROPHILE
NITRO-FATTY ACID
REDOX SIGNALING
topic EICOSANOID-SPECIFIC ENZYMES
ELECTROPHILE
NITRO-FATTY ACID
REDOX SIGNALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
Fil: Vitturi, Dario A.. University of Pittsburgh; Estados Unidos
Fil: Chen, Chen Shan. University of Pittsburgh; Estados Unidos
Fil: Woodcock, Steven R.. University of Pittsburgh; Estados Unidos
Fil: Salvatore, Sonia R.. University of Pittsburgh; Estados Unidos
Fil: Bonacci, Gustavo Roberto. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Koenitzer, Jeffrey R.. University of Pittsburgh; Estados Unidos
Fil: Stewart, Nicolas A.. University of Pittsburgh; Estados Unidos
Fil: Wakabayashi, Nobunao. University of Pittsburgh; Estados Unidos
Fil: Kensler, Thomas W.. University of Pittsburgh; Estados Unidos
Fil: Freeman, Bruce A.. University of Pittsburgh; Estados Unidos
Fil: Schopfer, Francisco J.. University of Pittsburgh; Estados Unidos
description Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26046
Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto; et al.; Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 288; 35; 8-2013; 25626-25637
0021-9258
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26046
identifier_str_mv Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto; et al.; Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 288; 35; 8-2013; 25626-25637
0021-9258
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M113.486282
info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/288/35/25626
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757223/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269891565977600
score 13.13397

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