Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride

Autores
Barbarini, Alejandro Luis; Estenoz, Diana Alejandra; Martino, Debora Marcela
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymeric micelles (PMs) composed of self-assembled amphiphilic block copolymers were synthesized from vinylbenzyl thymine (VBT) and vinylbenzyl triethylammonium chloride (VBA) exhibiting improved physical stability. Three diblock copolymers of different chemical compositions and similar molecular weights (polydispersities below 1.5) were obtained via nitroxide mediated radical polymerization. Critical micelle concentration (CMC) was determined by dye micellization method, the shift of the absorption peak of the anionic (EY) due to the interactions with non-assembled chains and auto-assembled copolymers was followed. Polymeric systems exhibited good stability revealing that a higher proportion of cationic monomers in the diblock reduce the CMC. Furthermore,
after the core of PMs was photocrosslinked by UV irradiation, the CMC decreases notably. Kinetic release studies using EY dye as probe demonstrated that both, higher VBA ratios in the polymer and higher UV-irradiation, slow down the dye release.
Fil: Barbarini, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Martino, Debora Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
Materia
Biomimetic
Copolymers
Drug Delivery Systems
Stimuli-Sensitive Polymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6537
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6537
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chlorideBarbarini, Alejandro LuisEstenoz, Diana AlejandraMartino, Debora MarcelaBiomimeticCopolymersDrug Delivery SystemsStimuli-Sensitive Polymershttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Polymeric micelles (PMs) composed of self-assembled amphiphilic block copolymers were synthesized from vinylbenzyl thymine (VBT) and vinylbenzyl triethylammonium chloride (VBA) exhibiting improved physical stability. Three diblock copolymers of different chemical compositions and similar molecular weights (polydispersities below 1.5) were obtained via nitroxide mediated radical polymerization. Critical micelle concentration (CMC) was determined by dye micellization method, the shift of the absorption peak of the anionic (EY) due to the interactions with non-assembled chains and auto-assembled copolymers was followed. Polymeric systems exhibited good stability revealing that a higher proportion of cationic monomers in the diblock reduce the CMC. Furthermore,<br />after the core of PMs was photocrosslinked by UV irradiation, the CMC decreases notably. Kinetic release studies using EY dye as probe demonstrated that both, higher VBA ratios in the polymer and higher UV-irradiation, slow down the dye release.Fil: Barbarini, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; ArgentinaFil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Martino, Debora Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; ArgentinaWiley2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6537Barbarini, Alejandro Luis; Estenoz, Diana Alejandra; Martino, Debora Marcela; Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride; Wiley; Journal of Applied Polymer Science; 132; 19; 5-2015; 6146-61560021-8995enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.41947/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/app.41947info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:57Zoai:ri.conicet.gov.ar:11336/6537instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:58.158CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
title Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
spellingShingle Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
Barbarini, Alejandro Luis
Biomimetic
Copolymers
Drug Delivery Systems
Stimuli-Sensitive Polymers
title_short Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
title_full Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
title_fullStr Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
title_full_unstemmed Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
title_sort Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride
dc.creator.none.fl_str_mv Barbarini, Alejandro Luis
Estenoz, Diana Alejandra
Martino, Debora Marcela
author Barbarini, Alejandro Luis
author_facet Barbarini, Alejandro Luis
Estenoz, Diana Alejandra
Martino, Debora Marcela
author_role author
author2 Estenoz, Diana Alejandra
Martino, Debora Marcela
author2_role author
author
dc.subject.none.fl_str_mv Biomimetic
Copolymers
Drug Delivery Systems
Stimuli-Sensitive Polymers
topic Biomimetic
Copolymers
Drug Delivery Systems
Stimuli-Sensitive Polymers
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Polymeric micelles (PMs) composed of self-assembled amphiphilic block copolymers were synthesized from vinylbenzyl thymine (VBT) and vinylbenzyl triethylammonium chloride (VBA) exhibiting improved physical stability. Three diblock copolymers of different chemical compositions and similar molecular weights (polydispersities below 1.5) were obtained via nitroxide mediated radical polymerization. Critical micelle concentration (CMC) was determined by dye micellization method, the shift of the absorption peak of the anionic (EY) due to the interactions with non-assembled chains and auto-assembled copolymers was followed. Polymeric systems exhibited good stability revealing that a higher proportion of cationic monomers in the diblock reduce the CMC. Furthermore,<br />after the core of PMs was photocrosslinked by UV irradiation, the CMC decreases notably. Kinetic release studies using EY dye as probe demonstrated that both, higher VBA ratios in the polymer and higher UV-irradiation, slow down the dye release.
Fil: Barbarini, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Martino, Debora Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
description Polymeric micelles (PMs) composed of self-assembled amphiphilic block copolymers were synthesized from vinylbenzyl thymine (VBT) and vinylbenzyl triethylammonium chloride (VBA) exhibiting improved physical stability. Three diblock copolymers of different chemical compositions and similar molecular weights (polydispersities below 1.5) were obtained via nitroxide mediated radical polymerization. Critical micelle concentration (CMC) was determined by dye micellization method, the shift of the absorption peak of the anionic (EY) due to the interactions with non-assembled chains and auto-assembled copolymers was followed. Polymeric systems exhibited good stability revealing that a higher proportion of cationic monomers in the diblock reduce the CMC. Furthermore,<br />after the core of PMs was photocrosslinked by UV irradiation, the CMC decreases notably. Kinetic release studies using EY dye as probe demonstrated that both, higher VBA ratios in the polymer and higher UV-irradiation, slow down the dye release.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6537
Barbarini, Alejandro Luis; Estenoz, Diana Alejandra; Martino, Debora Marcela; Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride; Wiley; Journal of Applied Polymer Science; 132; 19; 5-2015; 6146-6156
0021-8995
url http://hdl.handle.net/11336/6537
identifier_str_mv Barbarini, Alejandro Luis; Estenoz, Diana Alejandra; Martino, Debora Marcela; Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride; Wiley; Journal of Applied Polymer Science; 132; 19; 5-2015; 6146-6156
0021-8995
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.41947/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/app.41947
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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