Native plants and neuroprotective effects in diabetes mellitus

Autores
Rey, Mariana; Kruse, Maria Sol; Magrini Huamán, Rocío Nahimé; Tapia, A. A.; Feresin, Gabriela Egly; Coirini, Hector
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses "medicinal plants" to treat its health. Diabetes mellitus courses chronic hyperglycemia, oxidative stress state and neurodegenerative changes. Previously we had shown effects of Ta and Oe decoctions on LXRs expression in hypothalamus. In this work, adult male rats (SD), controls (C,i.p.veh) or diabetics (D,i.p.STZ30mg/Kg) drunk 10%W/V decoctions of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. The hypothalamic neural NOS (nNOS) and Neurofilaments200 (NF200, 3 different bands) expression levels were studied by WB. Compared to CW, DW, DOe and DTa had higher levels of Glu (350%, 200% and 200%; p<0.05) and Tg (200%, 300% and 200%; p<0.05). But, Glu in DTa and DOe was lower than DW (both 150%; p<0.05). No changes were observed in Chol among groups. All NF200 bands were higher in DW, COe and CTa than CW (28%; 14% and 19%; p<0.05). However, the value of NF200 in DTa were lower than DW (25%; p<0.05) and closer to CW. The nNOs in DW and COe were higher than in CW (43% and 70%; p<0.05), however the decoctions had not effect on D. Results suggest that these plants could have metabolic and neuroprotective effects. A more extended treatment will be necessary to propose Oe and Ta like new therapeutic tools
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Magrini Huamán, Rocío Nahimé. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tapia, A. A.. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”
Buenos Aires
Argentina
Sociedad Argentina de Biología
Sociedad Uruguaya de Biociencias
Materia
TESSARIA ABSINTHIOIDES
OXALIS ERYTHRORHIZA
DIABETES
GLUCOSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/137816
Acceder
id CONICETDig_c7be607a162153ccec1d6827ce209ad1
oai_identifier_str oai:ri.conicet.gov.ar:11336/137816
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Native plants and neuroprotective effects in diabetes mellitusRey, MarianaKruse, Maria SolMagrini Huamán, Rocío NahiméTapia, A. A.Feresin, Gabriela EglyCoirini, HectorTESSARIA ABSINTHIOIDESOXALIS ERYTHRORHIZADIABETESGLUCOSEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses "medicinal plants" to treat its health. Diabetes mellitus courses chronic hyperglycemia, oxidative stress state and neurodegenerative changes. Previously we had shown effects of Ta and Oe decoctions on LXRs expression in hypothalamus. In this work, adult male rats (SD), controls (C,i.p.veh) or diabetics (D,i.p.STZ30mg/Kg) drunk 10%W/V decoctions of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. The hypothalamic neural NOS (nNOS) and Neurofilaments200 (NF200, 3 different bands) expression levels were studied by WB. Compared to CW, DW, DOe and DTa had higher levels of Glu (350%, 200% and 200%; p<0.05) and Tg (200%, 300% and 200%; p<0.05). But, Glu in DTa and DOe was lower than DW (both 150%; p<0.05). No changes were observed in Chol among groups. All NF200 bands were higher in DW, COe and CTa than CW (28%; 14% and 19%; p<0.05). However, the value of NF200 in DTa were lower than DW (25%; p<0.05) and closer to CW. The nNOs in DW and COe were higher than in CW (43% and 70%; p<0.05), however the decoctions had not effect on D. Results suggest that these plants could have metabolic and neuroprotective effects. A more extended treatment will be necessary to propose Oe and Ta like new therapeutic toolsFil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Magrini Huamán, Rocío Nahimé. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tapia, A. A.. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaXX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”Buenos AiresArgentinaSociedad Argentina de BiologíaSociedad Uruguaya de BiocienciasInstituto de Histología y Embriología2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectJornadaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137816Native plants and neuroprotective effects in diabetes mellitus; XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”; Buenos Aires; Argentina; 2018; 47-470327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biologia.org.ar/resumen-jornadas-anuales-2018/info:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v43nSuppl.3/33866Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:08Zoai:ri.conicet.gov.ar:11336/137816instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:08.34CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Native plants and neuroprotective effects in diabetes mellitus
title Native plants and neuroprotective effects in diabetes mellitus
spellingShingle Native plants and neuroprotective effects in diabetes mellitus
Rey, Mariana
TESSARIA ABSINTHIOIDES
OXALIS ERYTHRORHIZA
DIABETES
GLUCOSE
title_short Native plants and neuroprotective effects in diabetes mellitus
title_full Native plants and neuroprotective effects in diabetes mellitus
title_fullStr Native plants and neuroprotective effects in diabetes mellitus
title_full_unstemmed Native plants and neuroprotective effects in diabetes mellitus
title_sort Native plants and neuroprotective effects in diabetes mellitus
dc.creator.none.fl_str_mv Rey, Mariana
Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Tapia, A. A.
Feresin, Gabriela Egly
Coirini, Hector
author Rey, Mariana
author_facet Rey, Mariana
Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Tapia, A. A.
Feresin, Gabriela Egly
Coirini, Hector
author_role author
author2 Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Tapia, A. A.
Feresin, Gabriela Egly
Coirini, Hector
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv TESSARIA ABSINTHIOIDES
OXALIS ERYTHRORHIZA
DIABETES
GLUCOSE
topic TESSARIA ABSINTHIOIDES
OXALIS ERYTHRORHIZA
DIABETES
GLUCOSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses "medicinal plants" to treat its health. Diabetes mellitus courses chronic hyperglycemia, oxidative stress state and neurodegenerative changes. Previously we had shown effects of Ta and Oe decoctions on LXRs expression in hypothalamus. In this work, adult male rats (SD), controls (C,i.p.veh) or diabetics (D,i.p.STZ30mg/Kg) drunk 10%W/V decoctions of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. The hypothalamic neural NOS (nNOS) and Neurofilaments200 (NF200, 3 different bands) expression levels were studied by WB. Compared to CW, DW, DOe and DTa had higher levels of Glu (350%, 200% and 200%; p<0.05) and Tg (200%, 300% and 200%; p<0.05). But, Glu in DTa and DOe was lower than DW (both 150%; p<0.05). No changes were observed in Chol among groups. All NF200 bands were higher in DW, COe and CTa than CW (28%; 14% and 19%; p<0.05). However, the value of NF200 in DTa were lower than DW (25%; p<0.05) and closer to CW. The nNOs in DW and COe were higher than in CW (43% and 70%; p<0.05), however the decoctions had not effect on D. Results suggest that these plants could have metabolic and neuroprotective effects. A more extended treatment will be necessary to propose Oe and Ta like new therapeutic tools
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Magrini Huamán, Rocío Nahimé. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tapia, A. A.. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”
Buenos Aires
Argentina
Sociedad Argentina de Biología
Sociedad Uruguaya de Biociencias
description In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses "medicinal plants" to treat its health. Diabetes mellitus courses chronic hyperglycemia, oxidative stress state and neurodegenerative changes. Previously we had shown effects of Ta and Oe decoctions on LXRs expression in hypothalamus. In this work, adult male rats (SD), controls (C,i.p.veh) or diabetics (D,i.p.STZ30mg/Kg) drunk 10%W/V decoctions of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. The hypothalamic neural NOS (nNOS) and Neurofilaments200 (NF200, 3 different bands) expression levels were studied by WB. Compared to CW, DW, DOe and DTa had higher levels of Glu (350%, 200% and 200%; p<0.05) and Tg (200%, 300% and 200%; p<0.05). But, Glu in DTa and DOe was lower than DW (both 150%; p<0.05). No changes were observed in Chol among groups. All NF200 bands were higher in DW, COe and CTa than CW (28%; 14% and 19%; p<0.05). However, the value of NF200 in DTa were lower than DW (25%; p<0.05) and closer to CW. The nNOs in DW and COe were higher than in CW (43% and 70%; p<0.05), however the decoctions had not effect on D. Results suggest that these plants could have metabolic and neuroprotective effects. A more extended treatment will be necessary to propose Oe and Ta like new therapeutic tools
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Jornada
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/137816
Native plants and neuroprotective effects in diabetes mellitus; XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”; Buenos Aires; Argentina; 2018; 47-47
0327-9545
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/137816
identifier_str_mv Native plants and neuroprotective effects in diabetes mellitus; XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias. “Nanobiotecnología: pequeñas soluciones para grandes problemas”; Buenos Aires; Argentina; 2018; 47-47
0327-9545
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.biologia.org.ar/resumen-jornadas-anuales-2018/
info:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v43nSuppl.3/33866
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Instituto de Histología y Embriología
publisher.none.fl_str_mv Instituto de Histología y Embriología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268711658979328
score 13.13397

Publicaciones similares