Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values

Autores
Cárdenas, Paola A.; Baena, Yolima; Aragón, Diana M.; Jimenez Kairuz, Alvaro Federico; Martinez, Fleming
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Based on van’t Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and mixing of 6-methylcoumarin in water at pH 1.2, 6.8, and 7.4, were evaluated from solubility values determined at five temperatures from 293.15 to 313.15 K. The solubility at all pH values was almost the same demonstrating a slight effect of pH on this physicochemical property. All the thermodynamic quantities of solution were positive indicating endothermic and entropy-driving dissolution processes at all pH values studied. The results were discussed in terms of solvent-solute and solventsolvent interactions, mainly hydrophobic hydration around non-polar groups of this drug.
Fil: Cárdenas, Paola A.. Universidad Nacional de Colombia; Colombia
Fil: Baena, Yolima. Universidad Nacional de Colombia; Colombia
Fil: Aragón, Diana M.. Universidad Nacional de Colombia; Colombia
Fil: Jimenez Kairuz, Alvaro Federico. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, Fleming. Universidad Nacional de Colombia; Colombia
Materia
6-Methylcoumarin
Aqueous Solubility
Solution Thermodynamics
Ph
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27297
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH ValuesCárdenas, Paola A.Baena, YolimaAragón, Diana M.Jimenez Kairuz, Alvaro FedericoMartinez, Fleming6-MethylcoumarinAqueous SolubilitySolution ThermodynamicsPhhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Based on van’t Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and mixing of 6-methylcoumarin in water at pH 1.2, 6.8, and 7.4, were evaluated from solubility values determined at five temperatures from 293.15 to 313.15 K. The solubility at all pH values was almost the same demonstrating a slight effect of pH on this physicochemical property. All the thermodynamic quantities of solution were positive indicating endothermic and entropy-driving dissolution processes at all pH values studied. The results were discussed in terms of solvent-solute and solventsolvent interactions, mainly hydrophobic hydration around non-polar groups of this drug.Fil: Cárdenas, Paola A.. Universidad Nacional de Colombia; ColombiaFil: Baena, Yolima. Universidad Nacional de Colombia; ColombiaFil: Aragón, Diana M.. Universidad Nacional de Colombia; ColombiaFil: Jimenez Kairuz, Alvaro Federico. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinez, Fleming. Universidad Nacional de Colombia; ColombiaColegio Farmaceuticos Provincia de Buenos Aires2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/27297Cárdenas, Paola A.; Baena, Yolima; Aragón, Diana M.; Jimenez Kairuz, Alvaro Federico; Martinez, Fleming; Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 32; 6; 4-2013; 793-8010326-2383CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=32&num=6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:21Zoai:ri.conicet.gov.ar:11336/27297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:21.451CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
title Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
spellingShingle Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
Cárdenas, Paola A.
6-Methylcoumarin
Aqueous Solubility
Solution Thermodynamics
Ph
title_short Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
title_full Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
title_fullStr Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
title_full_unstemmed Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
title_sort Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values
dc.creator.none.fl_str_mv Cárdenas, Paola A.
Baena, Yolima
Aragón, Diana M.
Jimenez Kairuz, Alvaro Federico
Martinez, Fleming
author Cárdenas, Paola A.
author_facet Cárdenas, Paola A.
Baena, Yolima
Aragón, Diana M.
Jimenez Kairuz, Alvaro Federico
Martinez, Fleming
author_role author
author2 Baena, Yolima
Aragón, Diana M.
Jimenez Kairuz, Alvaro Federico
Martinez, Fleming
author2_role author
author
author
author
dc.subject.none.fl_str_mv 6-Methylcoumarin
Aqueous Solubility
Solution Thermodynamics
Ph
topic 6-Methylcoumarin
Aqueous Solubility
Solution Thermodynamics
Ph
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Based on van’t Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and mixing of 6-methylcoumarin in water at pH 1.2, 6.8, and 7.4, were evaluated from solubility values determined at five temperatures from 293.15 to 313.15 K. The solubility at all pH values was almost the same demonstrating a slight effect of pH on this physicochemical property. All the thermodynamic quantities of solution were positive indicating endothermic and entropy-driving dissolution processes at all pH values studied. The results were discussed in terms of solvent-solute and solventsolvent interactions, mainly hydrophobic hydration around non-polar groups of this drug.
Fil: Cárdenas, Paola A.. Universidad Nacional de Colombia; Colombia
Fil: Baena, Yolima. Universidad Nacional de Colombia; Colombia
Fil: Aragón, Diana M.. Universidad Nacional de Colombia; Colombia
Fil: Jimenez Kairuz, Alvaro Federico. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, Fleming. Universidad Nacional de Colombia; Colombia
description Based on van’t Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and mixing of 6-methylcoumarin in water at pH 1.2, 6.8, and 7.4, were evaluated from solubility values determined at five temperatures from 293.15 to 313.15 K. The solubility at all pH values was almost the same demonstrating a slight effect of pH on this physicochemical property. All the thermodynamic quantities of solution were positive indicating endothermic and entropy-driving dissolution processes at all pH values studied. The results were discussed in terms of solvent-solute and solventsolvent interactions, mainly hydrophobic hydration around non-polar groups of this drug.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27297
Cárdenas, Paola A.; Baena, Yolima; Aragón, Diana M.; Jimenez Kairuz, Alvaro Federico; Martinez, Fleming; Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 32; 6; 4-2013; 793-801
0326-2383
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27297
identifier_str_mv Cárdenas, Paola A.; Baena, Yolima; Aragón, Diana M.; Jimenez Kairuz, Alvaro Federico; Martinez, Fleming; Solution Thermodynamics of 6-Methylcoumarin in Aqueous Media at Several pH Values; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 32; 6; 4-2013; 793-801
0326-2383
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=32&num=6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269152731987968
score 13.13397

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