Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes

Autores
Sookoian, Silvia Cristina; Fernández Gianotti, Tomás; Pirola, Carlos José
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism on left ventricular mass and related phenotypes. Design: From 485 reports, we included 14 studies concerning the relationship between the C-344T variant and left ventricular mass and left ventricular structure related-phenotypes, from which information about number of subjects in each category, outcomes data and genotyping performed with a validated molecular method could be extracted. Fixed and random effect models were used to pool data from individual studies, and the results in the abstract show the extreme genotype comparison, homozygous TT vs. homozygous CC. Results: From a total of 2157 subjects, we found no significant association between left ventricular mass (LVM) and the C-344T variant (D: 0.049, 95 % CI: 0.091 to 0.179, p=0.462). Similarly, no significant association was found for interventricular septal wall thickness (D: 0.027, 95 % CI: -0.090 to 0.143, p=0.654, n: 2105). However, homozygous TT hypertensive subjects had increased LVM (D: 0.251, 95 % CI: 0.020 to 0.481, p=0.04, n: 332). Lastly, in 10 homogeneous studies posterior wall thickness (PWT) was lower in homozygous CC individuals (D: 0.142, 95 % CI: 0.016 to 0.268, p=0.028, n: 1994). Conclusion: Independently of hypertension, homozygous individuals for the ?344T allele may have 2.4 % higher PWT as compared to homozygous subjects for the C-344 allele. Besides, homozygous hypertensive TT subjects show a 6.9 % increase in LVM compared to CC homozygous ones.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
ALDOSTERONE SYNTHASE OR CYP11B2
C-344T
GENETICS
LEFT VENTRICULAR HYPERTROPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105178
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/105178
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypesSookoian, Silvia CristinaFernández Gianotti, TomásPirola, Carlos JoséALDOSTERONE SYNTHASE OR CYP11B2C-344TGENETICSLEFT VENTRICULAR HYPERTROPHYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aim: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism on left ventricular mass and related phenotypes. Design: From 485 reports, we included 14 studies concerning the relationship between the C-344T variant and left ventricular mass and left ventricular structure related-phenotypes, from which information about number of subjects in each category, outcomes data and genotyping performed with a validated molecular method could be extracted. Fixed and random effect models were used to pool data from individual studies, and the results in the abstract show the extreme genotype comparison, homozygous TT vs. homozygous CC. Results: From a total of 2157 subjects, we found no significant association between left ventricular mass (LVM) and the C-344T variant (D: 0.049, 95 % CI: 0.091 to 0.179, p=0.462). Similarly, no significant association was found for interventricular septal wall thickness (D: 0.027, 95 % CI: -0.090 to 0.143, p=0.654, n: 2105). However, homozygous TT hypertensive subjects had increased LVM (D: 0.251, 95 % CI: 0.020 to 0.481, p=0.04, n: 332). Lastly, in 10 homogeneous studies posterior wall thickness (PWT) was lower in homozygous CC individuals (D: 0.142, 95 % CI: 0.016 to 0.268, p=0.028, n: 1994). Conclusion: Independently of hypertension, homozygous individuals for the ?344T allele may have 2.4 % higher PWT as compared to homozygous subjects for the C-344 allele. Besides, homozygous hypertensive TT subjects show a 6.9 % increase in LVM compared to CC homozygous ones.Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaB M J Publishing Group2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105178Sookoian, Silvia Cristina; Fernández Gianotti, Tomás; Pirola, Carlos José; Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes; B M J Publishing Group; Heart (british Cardiac Society); 94; 7; 7-2008; 903-9101355-6037CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://heart.bmj.com/content/94/7/903info:eu-repo/semantics/altIdentifier/doi/10.1136/hrt.2007.119545info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:51Zoai:ri.conicet.gov.ar:11336/105178instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:52.209CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
title Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
spellingShingle Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
Sookoian, Silvia Cristina
ALDOSTERONE SYNTHASE OR CYP11B2
C-344T
GENETICS
LEFT VENTRICULAR HYPERTROPHY
title_short Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
title_full Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
title_fullStr Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
title_full_unstemmed Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
title_sort Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes
dc.creator.none.fl_str_mv Sookoian, Silvia Cristina
Fernández Gianotti, Tomás
Pirola, Carlos José
author Sookoian, Silvia Cristina
author_facet Sookoian, Silvia Cristina
Fernández Gianotti, Tomás
Pirola, Carlos José
author_role author
author2 Fernández Gianotti, Tomás
Pirola, Carlos José
author2_role author
author
dc.subject.none.fl_str_mv ALDOSTERONE SYNTHASE OR CYP11B2
C-344T
GENETICS
LEFT VENTRICULAR HYPERTROPHY
topic ALDOSTERONE SYNTHASE OR CYP11B2
C-344T
GENETICS
LEFT VENTRICULAR HYPERTROPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aim: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism on left ventricular mass and related phenotypes. Design: From 485 reports, we included 14 studies concerning the relationship between the C-344T variant and left ventricular mass and left ventricular structure related-phenotypes, from which information about number of subjects in each category, outcomes data and genotyping performed with a validated molecular method could be extracted. Fixed and random effect models were used to pool data from individual studies, and the results in the abstract show the extreme genotype comparison, homozygous TT vs. homozygous CC. Results: From a total of 2157 subjects, we found no significant association between left ventricular mass (LVM) and the C-344T variant (D: 0.049, 95 % CI: 0.091 to 0.179, p=0.462). Similarly, no significant association was found for interventricular septal wall thickness (D: 0.027, 95 % CI: -0.090 to 0.143, p=0.654, n: 2105). However, homozygous TT hypertensive subjects had increased LVM (D: 0.251, 95 % CI: 0.020 to 0.481, p=0.04, n: 332). Lastly, in 10 homogeneous studies posterior wall thickness (PWT) was lower in homozygous CC individuals (D: 0.142, 95 % CI: 0.016 to 0.268, p=0.028, n: 1994). Conclusion: Independently of hypertension, homozygous individuals for the ?344T allele may have 2.4 % higher PWT as compared to homozygous subjects for the C-344 allele. Besides, homozygous hypertensive TT subjects show a 6.9 % increase in LVM compared to CC homozygous ones.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Aim: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism on left ventricular mass and related phenotypes. Design: From 485 reports, we included 14 studies concerning the relationship between the C-344T variant and left ventricular mass and left ventricular structure related-phenotypes, from which information about number of subjects in each category, outcomes data and genotyping performed with a validated molecular method could be extracted. Fixed and random effect models were used to pool data from individual studies, and the results in the abstract show the extreme genotype comparison, homozygous TT vs. homozygous CC. Results: From a total of 2157 subjects, we found no significant association between left ventricular mass (LVM) and the C-344T variant (D: 0.049, 95 % CI: 0.091 to 0.179, p=0.462). Similarly, no significant association was found for interventricular septal wall thickness (D: 0.027, 95 % CI: -0.090 to 0.143, p=0.654, n: 2105). However, homozygous TT hypertensive subjects had increased LVM (D: 0.251, 95 % CI: 0.020 to 0.481, p=0.04, n: 332). Lastly, in 10 homogeneous studies posterior wall thickness (PWT) was lower in homozygous CC individuals (D: 0.142, 95 % CI: 0.016 to 0.268, p=0.028, n: 1994). Conclusion: Independently of hypertension, homozygous individuals for the ?344T allele may have 2.4 % higher PWT as compared to homozygous subjects for the C-344 allele. Besides, homozygous hypertensive TT subjects show a 6.9 % increase in LVM compared to CC homozygous ones.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105178
Sookoian, Silvia Cristina; Fernández Gianotti, Tomás; Pirola, Carlos José; Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes; B M J Publishing Group; Heart (british Cardiac Society); 94; 7; 7-2008; 903-910
1355-6037
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105178
identifier_str_mv Sookoian, Silvia Cristina; Fernández Gianotti, Tomás; Pirola, Carlos José; Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes; B M J Publishing Group; Heart (british Cardiac Society); 94; 7; 7-2008; 903-910
1355-6037
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://heart.bmj.com/content/94/7/903
info:eu-repo/semantics/altIdentifier/doi/10.1136/hrt.2007.119545
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv B M J Publishing Group
publisher.none.fl_str_mv B M J Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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