Messages diffuse faster than messengers

Autores
Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.
Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados Unidos
Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mak, Don-On Daniel. University of Pennsylvania; Estados Unidos
Fil: Pearson, John E.. Los Alamos National Laboratory;
Materia
BINDING
EFFECTIVE DIFFUSION
FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING
TAGGED PARTICLES
TRAPS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71857

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network_name_str CONICET Digital (CONICET)
spelling Messages diffuse faster than messengersPando, BernardoPonce Dawson, Silvina MarthaMak, Don-On DanielPearson, John E.BINDINGEFFECTIVE DIFFUSIONFLUORESCENCE RECOVERY AFTER PHOTOBLEACHINGTAGGED PARTICLESTRAPShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados UnidosFil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Mak, Don-On Daniel. University of Pennsylvania; Estados UnidosFil: Pearson, John E.. Los Alamos National Laboratory;National Academy of Sciences2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71857Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-53420027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0509576103info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:15:33Zoai:ri.conicet.gov.ar:11336/71857instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:15:33.363CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Messages diffuse faster than messengers
title Messages diffuse faster than messengers
spellingShingle Messages diffuse faster than messengers
Pando, Bernardo
BINDING
EFFECTIVE DIFFUSION
FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING
TAGGED PARTICLES
TRAPS
title_short Messages diffuse faster than messengers
title_full Messages diffuse faster than messengers
title_fullStr Messages diffuse faster than messengers
title_full_unstemmed Messages diffuse faster than messengers
title_sort Messages diffuse faster than messengers
dc.creator.none.fl_str_mv Pando, Bernardo
Ponce Dawson, Silvina Martha
Mak, Don-On Daniel
Pearson, John E.
author Pando, Bernardo
author_facet Pando, Bernardo
Ponce Dawson, Silvina Martha
Mak, Don-On Daniel
Pearson, John E.
author_role author
author2 Ponce Dawson, Silvina Martha
Mak, Don-On Daniel
Pearson, John E.
author2_role author
author
author
dc.subject.none.fl_str_mv BINDING
EFFECTIVE DIFFUSION
FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING
TAGGED PARTICLES
TRAPS
topic BINDING
EFFECTIVE DIFFUSION
FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING
TAGGED PARTICLES
TRAPS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.
Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados Unidos
Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mak, Don-On Daniel. University of Pennsylvania; Estados Unidos
Fil: Pearson, John E.. Los Alamos National Laboratory;
description In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71857
Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-5342
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71857
identifier_str_mv Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-5342
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0509576103
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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