Messages diffuse faster than messengers
- Autores
- Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.
Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados Unidos
Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Mak, Don-On Daniel. University of Pennsylvania; Estados Unidos
Fil: Pearson, John E.. Los Alamos National Laboratory; - Materia
-
BINDING
EFFECTIVE DIFFUSION
FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING
TAGGED PARTICLES
TRAPS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/71857
Ver los metadatos del registro completo
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Messages diffuse faster than messengersPando, BernardoPonce Dawson, Silvina MarthaMak, Don-On DanielPearson, John E.BINDINGEFFECTIVE DIFFUSIONFLUORESCENCE RECOVERY AFTER PHOTOBLEACHINGTAGGED PARTICLESTRAPShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA.Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados UnidosFil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Mak, Don-On Daniel. University of Pennsylvania; Estados UnidosFil: Pearson, John E.. Los Alamos National Laboratory;National Academy of Sciences2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71857Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-53420027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0509576103info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:15:33Zoai:ri.conicet.gov.ar:11336/71857instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:15:33.363CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Messages diffuse faster than messengers |
title |
Messages diffuse faster than messengers |
spellingShingle |
Messages diffuse faster than messengers Pando, Bernardo BINDING EFFECTIVE DIFFUSION FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING TAGGED PARTICLES TRAPS |
title_short |
Messages diffuse faster than messengers |
title_full |
Messages diffuse faster than messengers |
title_fullStr |
Messages diffuse faster than messengers |
title_full_unstemmed |
Messages diffuse faster than messengers |
title_sort |
Messages diffuse faster than messengers |
dc.creator.none.fl_str_mv |
Pando, Bernardo Ponce Dawson, Silvina Martha Mak, Don-On Daniel Pearson, John E. |
author |
Pando, Bernardo |
author_facet |
Pando, Bernardo Ponce Dawson, Silvina Martha Mak, Don-On Daniel Pearson, John E. |
author_role |
author |
author2 |
Ponce Dawson, Silvina Martha Mak, Don-On Daniel Pearson, John E. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
BINDING EFFECTIVE DIFFUSION FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING TAGGED PARTICLES TRAPS |
topic |
BINDING EFFECTIVE DIFFUSION FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING TAGGED PARTICLES TRAPS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA. Fil: Pando, Bernardo. Massachusetts Institute of Technology; Estados Unidos Fil: Ponce Dawson, Silvina Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Mak, Don-On Daniel. University of Pennsylvania; Estados Unidos Fil: Pearson, John E.. Los Alamos National Laboratory; |
description |
In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is well known that binding to traps results in an effective diffusion coefficient that is smaller than the free coefficient in media free of traps. To measure effective diffusion coefficients in cells, "tagged" particles are often used. Radioactive calcium was used in a giant squid axon and in cytosolic extracts of Xenopus laevis oocytes. Fluorescence recovery after photobleaching yields diffusion coefficients from observations of the distribution of fluorescently labeled proteins. In the absence of traps, free diffusion coefficients give both the rate at which single-particle mean square displacements increase and the rate at which information in the form of inhomogeneities in particle concentration spread out with time. We show here that, in the presence of traps, information diffuses faster than single particles. Thus, messages diffuse faster than messengers. Tagged-particle experiments give the single-particle diffusion coefficients and, thus, can underestimate the rate of diffusive signal propagation. © 2006 by The National Academy of Sciences of the USA. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/71857 Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-5342 0027-8424 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/71857 |
identifier_str_mv |
Pando, Bernardo; Ponce Dawson, Silvina Martha; Mak, Don-On Daniel; Pearson, John E.; Messages diffuse faster than messengers; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 103; 14; 12-2006; 5338-5342 0027-8424 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0509576103 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
National Academy of Sciences |
publisher.none.fl_str_mv |
National Academy of Sciences |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |