Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients

Autores
Sánchez, Francisco Javier; Gonzalez, Valeria A.; Farrando, Martin; Baigorria Jayat, Ariel O.; Segovia Roldan, Margarita; Garciá Mendívil, Laura; Ordovás, Laura; Prado, Natalia Jorgelina; Pueyo, Esther; Diez, Emiliano Raúl
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aging leads to structural and electrophysiological changes that increase the risk of postoperative atrial arrhythmias; however, noninvasive preoperative markers of atrial proarrhythmic conditions are still needed. This study is aimed at assessing whether interatrial dyssynchrony determined using two-dimensional speckle tracking echocardiography relates to proarrhythmic structural and functional remodeling. A cohort of 45 patients in sinus rhythm referred for cardiac surgery was evaluated by echocardiography and surface electrocardiogram the day before the intervention. Transmembrane potential, connexin, and potassium channel distribution, inflammatory, and nitrooxidative markers were measured from right atrial tissue obtained from patients. A difference greater than 40 milliseconds between right and left atrial free wall contraction confirmed the presence of interatrial dyssynchrony in 21 patients. No difference in relation with age, previous diseases, and 2-dimensional echocardiographic findings as well as average values of global longitudinal right and left atrial strain were found between synchronic and dyssynchronic patients. Postoperative atrial fibrillation incidence increased from 8.3% in the synchronic group to 33.3% in the dyssynchronic ones. P wave duration showed no difference between groups. Action potentials from dyssynchronous patients decreased in amplitude, maximal rate of depolarization, and hyperpolarized. Duration at 30% of repolarization increased, being markedly shorter at 90% of repolarization. Only the dyssynchronous group showed early and delayed afterdepolarizations. Atrial tissue of dyssynchronous patients displayed lateralization of connexin 40 and increased connexin 43 expression and accumulation of tumor necrosis factor-α in the intercalated disc. Tumor necrosis factor-α did not colocalize, however, with lateralized connexin 40. Nitroxidative marks and KATP channels increased perivascularly and in myocytes. Our results demonstrate that, as compared to a traditional surface electrocardiogram, the novel noninvasive echocardiographic evaluation of interatrial dyssynchrony provides a better identification of nonaged-related proarrhythmic atrial remodeling with increased susceptibility to postoperative atrial fibrillation.
Fil: Sánchez, Francisco Javier. Universidad Nacional de Cuyo; Argentina. Clínica de Cuyo; Argentina
Fil: Gonzalez, Valeria A.. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; Argentina
Fil: Farrando, Martin. Clínica de Cuyo; Argentina
Fil: Baigorria Jayat, Ariel O.. Clínica de Cuyo; Argentina
Fil: Segovia Roldan, Margarita. Universidad de Zaragoza; España
Fil: Garciá Mendívil, Laura. Universidad de Zaragoza; España
Fil: Ordovás, Laura. Universidad de Zaragoza; España. Fundación Agencia Aragonesa para la Investigación y el Desarrollo; España
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Pueyo, Esther. Universidad de Zaragoza; España. Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
ATRIAL DYSSYNCHRONY
STRAIN ECHOCARDIOGRAPHY
OXIDATIVE STRESS
ARRHYTHMIA
CARDIAC SURGERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173285

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network_name_str CONICET Digital (CONICET)
spelling Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery PatientsSánchez, Francisco JavierGonzalez, Valeria A.Farrando, MartinBaigorria Jayat, Ariel O.Segovia Roldan, MargaritaGarciá Mendívil, LauraOrdovás, LauraPrado, Natalia JorgelinaPueyo, EstherDiez, Emiliano RaúlATRIAL DYSSYNCHRONYSTRAIN ECHOCARDIOGRAPHYOXIDATIVE STRESSARRHYTHMIACARDIAC SURGERYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aging leads to structural and electrophysiological changes that increase the risk of postoperative atrial arrhythmias; however, noninvasive preoperative markers of atrial proarrhythmic conditions are still needed. This study is aimed at assessing whether interatrial dyssynchrony determined using two-dimensional speckle tracking echocardiography relates to proarrhythmic structural and functional remodeling. A cohort of 45 patients in sinus rhythm referred for cardiac surgery was evaluated by echocardiography and surface electrocardiogram the day before the intervention. Transmembrane potential, connexin, and potassium channel distribution, inflammatory, and nitrooxidative markers were measured from right atrial tissue obtained from patients. A difference greater than 40 milliseconds between right and left atrial free wall contraction confirmed the presence of interatrial dyssynchrony in 21 patients. No difference in relation with age, previous diseases, and 2-dimensional echocardiographic findings as well as average values of global longitudinal right and left atrial strain were found between synchronic and dyssynchronic patients. Postoperative atrial fibrillation incidence increased from 8.3% in the synchronic group to 33.3% in the dyssynchronic ones. P wave duration showed no difference between groups. Action potentials from dyssynchronous patients decreased in amplitude, maximal rate of depolarization, and hyperpolarized. Duration at 30% of repolarization increased, being markedly shorter at 90% of repolarization. Only the dyssynchronous group showed early and delayed afterdepolarizations. Atrial tissue of dyssynchronous patients displayed lateralization of connexin 40 and increased connexin 43 expression and accumulation of tumor necrosis factor-α in the intercalated disc. Tumor necrosis factor-α did not colocalize, however, with lateralized connexin 40. Nitroxidative marks and KATP channels increased perivascularly and in myocytes. Our results demonstrate that, as compared to a traditional surface electrocardiogram, the novel noninvasive echocardiographic evaluation of interatrial dyssynchrony provides a better identification of nonaged-related proarrhythmic atrial remodeling with increased susceptibility to postoperative atrial fibrillation.Fil: Sánchez, Francisco Javier. Universidad Nacional de Cuyo; Argentina. Clínica de Cuyo; ArgentinaFil: Gonzalez, Valeria A.. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; ArgentinaFil: Farrando, Martin. Clínica de Cuyo; ArgentinaFil: Baigorria Jayat, Ariel O.. Clínica de Cuyo; ArgentinaFil: Segovia Roldan, Margarita. Universidad de Zaragoza; EspañaFil: Garciá Mendívil, Laura. Universidad de Zaragoza; EspañaFil: Ordovás, Laura. Universidad de Zaragoza; España. Fundación Agencia Aragonesa para la Investigación y el Desarrollo; EspañaFil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Pueyo, Esther. Universidad de Zaragoza; España. Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaHindawi Publishing Corporation2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173285Sánchez, Francisco Javier; Gonzalez, Valeria A.; Farrando, Martin; Baigorria Jayat, Ariel O.; Segovia Roldan, Margarita; et al.; Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2020; 3-2021; 1-141942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2020/8895078/info:eu-repo/semantics/altIdentifier/doi/10.1155/2020/8895078info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:14Zoai:ri.conicet.gov.ar:11336/173285instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:14.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
title Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
spellingShingle Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
Sánchez, Francisco Javier
ATRIAL DYSSYNCHRONY
STRAIN ECHOCARDIOGRAPHY
OXIDATIVE STRESS
ARRHYTHMIA
CARDIAC SURGERY
title_short Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
title_full Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
title_fullStr Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
title_full_unstemmed Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
title_sort Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
dc.creator.none.fl_str_mv Sánchez, Francisco Javier
Gonzalez, Valeria A.
Farrando, Martin
Baigorria Jayat, Ariel O.
Segovia Roldan, Margarita
Garciá Mendívil, Laura
Ordovás, Laura
Prado, Natalia Jorgelina
Pueyo, Esther
Diez, Emiliano Raúl
author Sánchez, Francisco Javier
author_facet Sánchez, Francisco Javier
Gonzalez, Valeria A.
Farrando, Martin
Baigorria Jayat, Ariel O.
Segovia Roldan, Margarita
Garciá Mendívil, Laura
Ordovás, Laura
Prado, Natalia Jorgelina
Pueyo, Esther
Diez, Emiliano Raúl
author_role author
author2 Gonzalez, Valeria A.
Farrando, Martin
Baigorria Jayat, Ariel O.
Segovia Roldan, Margarita
Garciá Mendívil, Laura
Ordovás, Laura
Prado, Natalia Jorgelina
Pueyo, Esther
Diez, Emiliano Raúl
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ATRIAL DYSSYNCHRONY
STRAIN ECHOCARDIOGRAPHY
OXIDATIVE STRESS
ARRHYTHMIA
CARDIAC SURGERY
topic ATRIAL DYSSYNCHRONY
STRAIN ECHOCARDIOGRAPHY
OXIDATIVE STRESS
ARRHYTHMIA
CARDIAC SURGERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aging leads to structural and electrophysiological changes that increase the risk of postoperative atrial arrhythmias; however, noninvasive preoperative markers of atrial proarrhythmic conditions are still needed. This study is aimed at assessing whether interatrial dyssynchrony determined using two-dimensional speckle tracking echocardiography relates to proarrhythmic structural and functional remodeling. A cohort of 45 patients in sinus rhythm referred for cardiac surgery was evaluated by echocardiography and surface electrocardiogram the day before the intervention. Transmembrane potential, connexin, and potassium channel distribution, inflammatory, and nitrooxidative markers were measured from right atrial tissue obtained from patients. A difference greater than 40 milliseconds between right and left atrial free wall contraction confirmed the presence of interatrial dyssynchrony in 21 patients. No difference in relation with age, previous diseases, and 2-dimensional echocardiographic findings as well as average values of global longitudinal right and left atrial strain were found between synchronic and dyssynchronic patients. Postoperative atrial fibrillation incidence increased from 8.3% in the synchronic group to 33.3% in the dyssynchronic ones. P wave duration showed no difference between groups. Action potentials from dyssynchronous patients decreased in amplitude, maximal rate of depolarization, and hyperpolarized. Duration at 30% of repolarization increased, being markedly shorter at 90% of repolarization. Only the dyssynchronous group showed early and delayed afterdepolarizations. Atrial tissue of dyssynchronous patients displayed lateralization of connexin 40 and increased connexin 43 expression and accumulation of tumor necrosis factor-α in the intercalated disc. Tumor necrosis factor-α did not colocalize, however, with lateralized connexin 40. Nitroxidative marks and KATP channels increased perivascularly and in myocytes. Our results demonstrate that, as compared to a traditional surface electrocardiogram, the novel noninvasive echocardiographic evaluation of interatrial dyssynchrony provides a better identification of nonaged-related proarrhythmic atrial remodeling with increased susceptibility to postoperative atrial fibrillation.
Fil: Sánchez, Francisco Javier. Universidad Nacional de Cuyo; Argentina. Clínica de Cuyo; Argentina
Fil: Gonzalez, Valeria A.. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; Argentina
Fil: Farrando, Martin. Clínica de Cuyo; Argentina
Fil: Baigorria Jayat, Ariel O.. Clínica de Cuyo; Argentina
Fil: Segovia Roldan, Margarita. Universidad de Zaragoza; España
Fil: Garciá Mendívil, Laura. Universidad de Zaragoza; España
Fil: Ordovás, Laura. Universidad de Zaragoza; España. Fundación Agencia Aragonesa para la Investigación y el Desarrollo; España
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Pueyo, Esther. Universidad de Zaragoza; España. Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Aging leads to structural and electrophysiological changes that increase the risk of postoperative atrial arrhythmias; however, noninvasive preoperative markers of atrial proarrhythmic conditions are still needed. This study is aimed at assessing whether interatrial dyssynchrony determined using two-dimensional speckle tracking echocardiography relates to proarrhythmic structural and functional remodeling. A cohort of 45 patients in sinus rhythm referred for cardiac surgery was evaluated by echocardiography and surface electrocardiogram the day before the intervention. Transmembrane potential, connexin, and potassium channel distribution, inflammatory, and nitrooxidative markers were measured from right atrial tissue obtained from patients. A difference greater than 40 milliseconds between right and left atrial free wall contraction confirmed the presence of interatrial dyssynchrony in 21 patients. No difference in relation with age, previous diseases, and 2-dimensional echocardiographic findings as well as average values of global longitudinal right and left atrial strain were found between synchronic and dyssynchronic patients. Postoperative atrial fibrillation incidence increased from 8.3% in the synchronic group to 33.3% in the dyssynchronic ones. P wave duration showed no difference between groups. Action potentials from dyssynchronous patients decreased in amplitude, maximal rate of depolarization, and hyperpolarized. Duration at 30% of repolarization increased, being markedly shorter at 90% of repolarization. Only the dyssynchronous group showed early and delayed afterdepolarizations. Atrial tissue of dyssynchronous patients displayed lateralization of connexin 40 and increased connexin 43 expression and accumulation of tumor necrosis factor-α in the intercalated disc. Tumor necrosis factor-α did not colocalize, however, with lateralized connexin 40. Nitroxidative marks and KATP channels increased perivascularly and in myocytes. Our results demonstrate that, as compared to a traditional surface electrocardiogram, the novel noninvasive echocardiographic evaluation of interatrial dyssynchrony provides a better identification of nonaged-related proarrhythmic atrial remodeling with increased susceptibility to postoperative atrial fibrillation.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173285
Sánchez, Francisco Javier; Gonzalez, Valeria A.; Farrando, Martin; Baigorria Jayat, Ariel O.; Segovia Roldan, Margarita; et al.; Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2020; 3-2021; 1-14
1942-0994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173285
identifier_str_mv Sánchez, Francisco Javier; Gonzalez, Valeria A.; Farrando, Martin; Baigorria Jayat, Ariel O.; Segovia Roldan, Margarita; et al.; Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2020; 3-2021; 1-14
1942-0994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2020/8895078/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2020/8895078
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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