Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

Autores
Correia da Silva, Ricardo; Pires Cavalcanti Teixeira, Mariana; Souza de Paiva, Luciana; Miranda Alves, Leandro
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tributyltin (TBT) is an environmental contaminant present on all continents, including Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It was effectively banned in 2003 but remains in the environment to this day due to several factors that increase its half-life and its misuse despite the bans. In addition to the endocrine-disrupting effect of TBT, which may lead to imposex induction in some invertebrate species, there are several studies that demonstrate that TBT also has an immunotoxic effect. The immunotoxic effects that have been observed experimentally in vertebrates using in vitro and in vivo models involve different mechanisms; mainly, there are alterations in the expression and/or secretion of cytokines. In this review, we summarize and update the literature on the impacts of TBT on the immune system, and we discuss issues that still need to be explored to fill the knowledge gaps regarding the impact of this endocrine-disrupting chemical on immune system homeostasis.
Fil: Correia da Silva, Ricardo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Pires Cavalcanti Teixeira, Mariana. Universidade Federal do Rio de Janeiro; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Souza de Paiva, Luciana. Universidade Federal Fluminense; Brasil
Fil: Miranda Alves, Leandro. Universidade Federal do Rio de Janeiro; Brasil
Materia
CYTOKINES
ENDOCRINE-DISRUPTING CHEMICAL
IMMUNE SYSTEM
IMMUNOTOXICITY
ORGANOTIN
TRIBUTYLTIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226180
Acceder
id CONICETDig_c5490675d5d4dae7f680b324f2470b02
oai_identifier_str oai:ri.conicet.gov.ar:11336/226180
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical TributyltinCorreia da Silva, RicardoPires Cavalcanti Teixeira, MarianaSouza de Paiva, LucianaMiranda Alves, LeandroCYTOKINESENDOCRINE-DISRUPTING CHEMICALIMMUNE SYSTEMIMMUNOTOXICITYORGANOTINTRIBUTYLTINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tributyltin (TBT) is an environmental contaminant present on all continents, including Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It was effectively banned in 2003 but remains in the environment to this day due to several factors that increase its half-life and its misuse despite the bans. In addition to the endocrine-disrupting effect of TBT, which may lead to imposex induction in some invertebrate species, there are several studies that demonstrate that TBT also has an immunotoxic effect. The immunotoxic effects that have been observed experimentally in vertebrates using in vitro and in vivo models involve different mechanisms; mainly, there are alterations in the expression and/or secretion of cytokines. In this review, we summarize and update the literature on the impacts of TBT on the immune system, and we discuss issues that still need to be explored to fill the knowledge gaps regarding the impact of this endocrine-disrupting chemical on immune system homeostasis.Fil: Correia da Silva, Ricardo. Universidade Federal do Rio de Janeiro; BrasilFil: Pires Cavalcanti Teixeira, Mariana. Universidade Federal do Rio de Janeiro; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Souza de Paiva, Luciana. Universidade Federal Fluminense; BrasilFil: Miranda Alves, Leandro. Universidade Federal do Rio de Janeiro; BrasilMDPI2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226180Correia da Silva, Ricardo; Pires Cavalcanti Teixeira, Mariana; Souza de Paiva, Luciana; Miranda Alves, Leandro; Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin; MDPI; Toxics; 11; 8; 8-2023; 1-172305-6304CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2305-6304/11/8/696info:eu-repo/semantics/altIdentifier/doi/10.3390/toxics11080696info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:47:26Zoai:ri.conicet.gov.ar:11336/226180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:47:26.757CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
title Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
spellingShingle Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
Correia da Silva, Ricardo
CYTOKINES
ENDOCRINE-DISRUPTING CHEMICAL
IMMUNE SYSTEM
IMMUNOTOXICITY
ORGANOTIN
TRIBUTYLTIN
title_short Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
title_full Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
title_fullStr Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
title_full_unstemmed Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
title_sort Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin
dc.creator.none.fl_str_mv Correia da Silva, Ricardo
Pires Cavalcanti Teixeira, Mariana
Souza de Paiva, Luciana
Miranda Alves, Leandro
author Correia da Silva, Ricardo
author_facet Correia da Silva, Ricardo
Pires Cavalcanti Teixeira, Mariana
Souza de Paiva, Luciana
Miranda Alves, Leandro
author_role author
author2 Pires Cavalcanti Teixeira, Mariana
Souza de Paiva, Luciana
Miranda Alves, Leandro
author2_role author
author
author
dc.subject.none.fl_str_mv CYTOKINES
ENDOCRINE-DISRUPTING CHEMICAL
IMMUNE SYSTEM
IMMUNOTOXICITY
ORGANOTIN
TRIBUTYLTIN
topic CYTOKINES
ENDOCRINE-DISRUPTING CHEMICAL
IMMUNE SYSTEM
IMMUNOTOXICITY
ORGANOTIN
TRIBUTYLTIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tributyltin (TBT) is an environmental contaminant present on all continents, including Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It was effectively banned in 2003 but remains in the environment to this day due to several factors that increase its half-life and its misuse despite the bans. In addition to the endocrine-disrupting effect of TBT, which may lead to imposex induction in some invertebrate species, there are several studies that demonstrate that TBT also has an immunotoxic effect. The immunotoxic effects that have been observed experimentally in vertebrates using in vitro and in vivo models involve different mechanisms; mainly, there are alterations in the expression and/or secretion of cytokines. In this review, we summarize and update the literature on the impacts of TBT on the immune system, and we discuss issues that still need to be explored to fill the knowledge gaps regarding the impact of this endocrine-disrupting chemical on immune system homeostasis.
Fil: Correia da Silva, Ricardo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Pires Cavalcanti Teixeira, Mariana. Universidade Federal do Rio de Janeiro; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Souza de Paiva, Luciana. Universidade Federal Fluminense; Brasil
Fil: Miranda Alves, Leandro. Universidade Federal do Rio de Janeiro; Brasil
description Tributyltin (TBT) is an environmental contaminant present on all continents, including Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It was effectively banned in 2003 but remains in the environment to this day due to several factors that increase its half-life and its misuse despite the bans. In addition to the endocrine-disrupting effect of TBT, which may lead to imposex induction in some invertebrate species, there are several studies that demonstrate that TBT also has an immunotoxic effect. The immunotoxic effects that have been observed experimentally in vertebrates using in vitro and in vivo models involve different mechanisms; mainly, there are alterations in the expression and/or secretion of cytokines. In this review, we summarize and update the literature on the impacts of TBT on the immune system, and we discuss issues that still need to be explored to fill the knowledge gaps regarding the impact of this endocrine-disrupting chemical on immune system homeostasis.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226180
Correia da Silva, Ricardo; Pires Cavalcanti Teixeira, Mariana; Souza de Paiva, Luciana; Miranda Alves, Leandro; Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin; MDPI; Toxics; 11; 8; 8-2023; 1-17
2305-6304
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226180
identifier_str_mv Correia da Silva, Ricardo; Pires Cavalcanti Teixeira, Mariana; Souza de Paiva, Luciana; Miranda Alves, Leandro; Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin; MDPI; Toxics; 11; 8; 8-2023; 1-17
2305-6304
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2305-6304/11/8/696
info:eu-repo/semantics/altIdentifier/doi/10.3390/toxics11080696
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782180259266560
score 12.982451

Publicaciones similares