Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury

Autores
Sámano, Cynthia; Mladinic, Miranda; Mazzone, Graciela Luján
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex gene alterations and activation of the neuroimmune system influence either cell damage or repair. Effective therapies to avoid secondary mechanisms underlying SCI are still lacking. The recent progression in circular RNAs (circRNAs) research has drawn increasing attention and opened a new insight on SCI pathology. circRNAs differ from traditional linear RNAs and have emerged as the active elements to regulate gene expression as well as to facilitate the immune response involved in pathophysiology-related conditions. In this review, we focus on the impact and possible close relationship of circRNAs with pathophysiological mechanisms following SCI, where circRNAs could be the key transcriptional regulatory molecules to define neuronal death or survival. Advances in circRNAs research provide new insight on potential biomarkers and effective therapeutic targets for SCI patients.
Fil: Sámano, Cynthia. Universidad Autónoma Metropolitana; México
Fil: Mladinic, Miranda. University Of Rijeka; Croacia
Fil: Mazzone, Graciela Luján. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Materia
BIOMARKERS
CIRCRNAS
CIRCRNAS IN CENTRAL NERVOUS SYSTEM
NON-CODING RNA
SPINAL CORD INJURY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184263
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord InjurySámano, CynthiaMladinic, MirandaMazzone, Graciela LujánBIOMARKERSCIRCRNASCIRCRNAS IN CENTRAL NERVOUS SYSTEMNON-CODING RNASPINAL CORD INJURYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex gene alterations and activation of the neuroimmune system influence either cell damage or repair. Effective therapies to avoid secondary mechanisms underlying SCI are still lacking. The recent progression in circular RNAs (circRNAs) research has drawn increasing attention and opened a new insight on SCI pathology. circRNAs differ from traditional linear RNAs and have emerged as the active elements to regulate gene expression as well as to facilitate the immune response involved in pathophysiology-related conditions. In this review, we focus on the impact and possible close relationship of circRNAs with pathophysiological mechanisms following SCI, where circRNAs could be the key transcriptional regulatory molecules to define neuronal death or survival. Advances in circRNAs research provide new insight on potential biomarkers and effective therapeutic targets for SCI patients.Fil: Sámano, Cynthia. Universidad Autónoma Metropolitana; MéxicoFil: Mladinic, Miranda. University Of Rijeka; CroaciaFil: Mazzone, Graciela Luján. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFrontiers Media2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184263Sámano, Cynthia; Mladinic, Miranda; Mazzone, Graciela Luján; Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury; Frontiers Media; Frontiers in Integrative Neuroscience; 15; 10-2021; 1-71662-5145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnint.2021.758340/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnint.2021.758340info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:01Zoai:ri.conicet.gov.ar:11336/184263instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:01.561CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
title Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
spellingShingle Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
Sámano, Cynthia
BIOMARKERS
CIRCRNAS
CIRCRNAS IN CENTRAL NERVOUS SYSTEM
NON-CODING RNA
SPINAL CORD INJURY
title_short Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
title_full Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
title_fullStr Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
title_full_unstemmed Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
title_sort Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
dc.creator.none.fl_str_mv Sámano, Cynthia
Mladinic, Miranda
Mazzone, Graciela Luján
author Sámano, Cynthia
author_facet Sámano, Cynthia
Mladinic, Miranda
Mazzone, Graciela Luján
author_role author
author2 Mladinic, Miranda
Mazzone, Graciela Luján
author2_role author
author
dc.subject.none.fl_str_mv BIOMARKERS
CIRCRNAS
CIRCRNAS IN CENTRAL NERVOUS SYSTEM
NON-CODING RNA
SPINAL CORD INJURY
topic BIOMARKERS
CIRCRNAS
CIRCRNAS IN CENTRAL NERVOUS SYSTEM
NON-CODING RNA
SPINAL CORD INJURY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex gene alterations and activation of the neuroimmune system influence either cell damage or repair. Effective therapies to avoid secondary mechanisms underlying SCI are still lacking. The recent progression in circular RNAs (circRNAs) research has drawn increasing attention and opened a new insight on SCI pathology. circRNAs differ from traditional linear RNAs and have emerged as the active elements to regulate gene expression as well as to facilitate the immune response involved in pathophysiology-related conditions. In this review, we focus on the impact and possible close relationship of circRNAs with pathophysiological mechanisms following SCI, where circRNAs could be the key transcriptional regulatory molecules to define neuronal death or survival. Advances in circRNAs research provide new insight on potential biomarkers and effective therapeutic targets for SCI patients.
Fil: Sámano, Cynthia. Universidad Autónoma Metropolitana; México
Fil: Mladinic, Miranda. University Of Rijeka; Croacia
Fil: Mazzone, Graciela Luján. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
description Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex gene alterations and activation of the neuroimmune system influence either cell damage or repair. Effective therapies to avoid secondary mechanisms underlying SCI are still lacking. The recent progression in circular RNAs (circRNAs) research has drawn increasing attention and opened a new insight on SCI pathology. circRNAs differ from traditional linear RNAs and have emerged as the active elements to regulate gene expression as well as to facilitate the immune response involved in pathophysiology-related conditions. In this review, we focus on the impact and possible close relationship of circRNAs with pathophysiological mechanisms following SCI, where circRNAs could be the key transcriptional regulatory molecules to define neuronal death or survival. Advances in circRNAs research provide new insight on potential biomarkers and effective therapeutic targets for SCI patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184263
Sámano, Cynthia; Mladinic, Miranda; Mazzone, Graciela Luján; Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury; Frontiers Media; Frontiers in Integrative Neuroscience; 15; 10-2021; 1-7
1662-5145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184263
identifier_str_mv Sámano, Cynthia; Mladinic, Miranda; Mazzone, Graciela Luján; Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury; Frontiers Media; Frontiers in Integrative Neuroscience; 15; 10-2021; 1-7
1662-5145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnint.2021.758340/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnint.2021.758340
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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