Phosphatidic acid metabolism in rat liver cell nuclei

Autores
Gaveglio, Virginia Lucía; Pasquaré, Susana Juana; Giusto, Norma Maria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG production while sphingosine 1-phoshate and ceramide 1-phosphate reduced MAG formation from PA. Using different enzymatic modulators (detergents and ions) an increase in the PA metabolism by phospholipase type A was observed. Our findings evidence an active PA metabolism in purified liver nuclei which generates important lipid second messengers, and which could thus be involved in nuclear processes such as gene transcription.
Fil: Gaveglio, Virginia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
Fil: Pasquaré, Susana Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
Fil: Giusto, Norma Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
Materia
Diacylglycerol
Liver
Monoacylglycerol
Nuclei
Phosphatidic Acid
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4554
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Phosphatidic acid metabolism in rat liver cell nucleiGaveglio, Virginia LucíaPasquaré, Susana JuanaGiusto, Norma MariaDiacylglycerolLiverMonoacylglycerolNucleiPhosphatidic Acidhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG production while sphingosine 1-phoshate and ceramide 1-phosphate reduced MAG formation from PA. Using different enzymatic modulators (detergents and ions) an increase in the PA metabolism by phospholipase type A was observed. Our findings evidence an active PA metabolism in purified liver nuclei which generates important lipid second messengers, and which could thus be involved in nuclear processes such as gene transcription.Fil: Gaveglio, Virginia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; ArgentinaFil: Pasquaré, Susana Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; ArgentinaFil: Giusto, Norma Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; ArgentinaElsevier Science2013-02-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4554Gaveglio, Virginia Lucía; Pasquaré, Susana Juana; Giusto, Norma Maria; Phosphatidic acid metabolism in rat liver cell nuclei; Elsevier Science; Febs Letters; 587; 7; 21-2-2013; 950-9560014-5793enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.febslet.2013.01.074/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2013.01.074info:eu-repo/semantics/altIdentifier/issn/0014-5793info:eu-repo/semantics/altIdentifier/ark/http://www.sciencedirect.com/science/article/pii/S0014579313001579info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:38:17Zoai:ri.conicet.gov.ar:11336/4554instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:38:17.37CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phosphatidic acid metabolism in rat liver cell nuclei
title Phosphatidic acid metabolism in rat liver cell nuclei
spellingShingle Phosphatidic acid metabolism in rat liver cell nuclei
Gaveglio, Virginia Lucía
Diacylglycerol
Liver
Monoacylglycerol
Nuclei
Phosphatidic Acid
title_short Phosphatidic acid metabolism in rat liver cell nuclei
title_full Phosphatidic acid metabolism in rat liver cell nuclei
title_fullStr Phosphatidic acid metabolism in rat liver cell nuclei
title_full_unstemmed Phosphatidic acid metabolism in rat liver cell nuclei
title_sort Phosphatidic acid metabolism in rat liver cell nuclei
dc.creator.none.fl_str_mv Gaveglio, Virginia Lucía
Pasquaré, Susana Juana
Giusto, Norma Maria
author Gaveglio, Virginia Lucía
author_facet Gaveglio, Virginia Lucía
Pasquaré, Susana Juana
Giusto, Norma Maria
author_role author
author2 Pasquaré, Susana Juana
Giusto, Norma Maria
author2_role author
author
dc.subject.none.fl_str_mv Diacylglycerol
Liver
Monoacylglycerol
Nuclei
Phosphatidic Acid
topic Diacylglycerol
Liver
Monoacylglycerol
Nuclei
Phosphatidic Acid
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG production while sphingosine 1-phoshate and ceramide 1-phosphate reduced MAG formation from PA. Using different enzymatic modulators (detergents and ions) an increase in the PA metabolism by phospholipase type A was observed. Our findings evidence an active PA metabolism in purified liver nuclei which generates important lipid second messengers, and which could thus be involved in nuclear processes such as gene transcription.
Fil: Gaveglio, Virginia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
Fil: Pasquaré, Susana Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
Fil: Giusto, Norma Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
description The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG production while sphingosine 1-phoshate and ceramide 1-phosphate reduced MAG formation from PA. Using different enzymatic modulators (detergents and ions) an increase in the PA metabolism by phospholipase type A was observed. Our findings evidence an active PA metabolism in purified liver nuclei which generates important lipid second messengers, and which could thus be involved in nuclear processes such as gene transcription.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4554
Gaveglio, Virginia Lucía; Pasquaré, Susana Juana; Giusto, Norma Maria; Phosphatidic acid metabolism in rat liver cell nuclei; Elsevier Science; Febs Letters; 587; 7; 21-2-2013; 950-956
0014-5793
url http://hdl.handle.net/11336/4554
identifier_str_mv Gaveglio, Virginia Lucía; Pasquaré, Susana Juana; Giusto, Norma Maria; Phosphatidic acid metabolism in rat liver cell nuclei; Elsevier Science; Febs Letters; 587; 7; 21-2-2013; 950-956
0014-5793
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.febslet.2013.01.074/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2013.01.074
info:eu-repo/semantics/altIdentifier/issn/0014-5793
info:eu-repo/semantics/altIdentifier/ark/http://www.sciencedirect.com/science/article/pii/S0014579313001579
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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