Allostatic-interoceptive anticipation of social rejection

Autores
Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; García, Adolfo Martín; García, María del Carmen; Ortega, Rodrigo; Lawlor, Brian; Lopez, Vladimir; Ibañez, Agustin Mariano
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress.
Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile
Fil: Hesse Rizzi, Eugenia Fátima. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Mejía, Jhonny. Universidad Adolfo Ibáñez; Chile
Fil: Fraile, Matías. Universidad de San Andrés; Argentina
Fil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García, María del Carmen. Hospital Italiano; Argentina
Fil: Ortega, Rodrigo. Universidad Adolfo Ibañez; Chile
Fil: Lawlor, Brian. University of California; Estados Unidos
Fil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile
Materia
ALLOSTATIC INTEROCEPTION
SOCIAL REJECTION
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220505
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Allostatic-interoceptive anticipation of social rejectionMigeot, JoaquínHesse Rizzi, Eugenia FátimaFittipaldi, SolMejía, JhonnyFraile, MatíasGarcía, Adolfo MartínGarcía, María del CarmenOrtega, RodrigoLawlor, BrianLopez, VladimirIbañez, Agustin MarianoALLOSTATIC INTEROCEPTIONSOCIAL REJECTIONhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress.Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; ChileFil: Hesse Rizzi, Eugenia Fátima. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; ChileFil: Mejía, Jhonny. Universidad Adolfo Ibáñez; ChileFil: Fraile, Matías. Universidad de San Andrés; ArgentinaFil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: García, María del Carmen. Hospital Italiano; ArgentinaFil: Ortega, Rodrigo. Universidad Adolfo Ibañez; ChileFil: Lawlor, Brian. University of California; Estados UnidosFil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; ChileAcademic Press Inc Elsevier Science2023-08info:eu-repo/date/embargoEnd/2024-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220505Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; et al.; Allostatic-interoceptive anticipation of social rejection; Academic Press Inc Elsevier Science; Neuroimage; 276; 8-2023; 1-311053-8119CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1053811923003518?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroimage.2023.120200info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:02Zoai:ri.conicet.gov.ar:11336/220505instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:02.84CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Allostatic-interoceptive anticipation of social rejection
title Allostatic-interoceptive anticipation of social rejection
spellingShingle Allostatic-interoceptive anticipation of social rejection
Migeot, Joaquín
ALLOSTATIC INTEROCEPTION
SOCIAL REJECTION
title_short Allostatic-interoceptive anticipation of social rejection
title_full Allostatic-interoceptive anticipation of social rejection
title_fullStr Allostatic-interoceptive anticipation of social rejection
title_full_unstemmed Allostatic-interoceptive anticipation of social rejection
title_sort Allostatic-interoceptive anticipation of social rejection
dc.creator.none.fl_str_mv Migeot, Joaquín
Hesse Rizzi, Eugenia Fátima
Fittipaldi, Sol
Mejía, Jhonny
Fraile, Matías
García, Adolfo Martín
García, María del Carmen
Ortega, Rodrigo
Lawlor, Brian
Lopez, Vladimir
Ibañez, Agustin Mariano
author Migeot, Joaquín
author_facet Migeot, Joaquín
Hesse Rizzi, Eugenia Fátima
Fittipaldi, Sol
Mejía, Jhonny
Fraile, Matías
García, Adolfo Martín
García, María del Carmen
Ortega, Rodrigo
Lawlor, Brian
Lopez, Vladimir
Ibañez, Agustin Mariano
author_role author
author2 Hesse Rizzi, Eugenia Fátima
Fittipaldi, Sol
Mejía, Jhonny
Fraile, Matías
García, Adolfo Martín
García, María del Carmen
Ortega, Rodrigo
Lawlor, Brian
Lopez, Vladimir
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALLOSTATIC INTEROCEPTION
SOCIAL REJECTION
topic ALLOSTATIC INTEROCEPTION
SOCIAL REJECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress.
Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile
Fil: Hesse Rizzi, Eugenia Fátima. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Mejía, Jhonny. Universidad Adolfo Ibáñez; Chile
Fil: Fraile, Matías. Universidad de San Andrés; Argentina
Fil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García, María del Carmen. Hospital Italiano; Argentina
Fil: Ortega, Rodrigo. Universidad Adolfo Ibañez; Chile
Fil: Lawlor, Brian. University of California; Estados Unidos
Fil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile
description Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
info:eu-repo/date/embargoEnd/2024-02-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220505
Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; et al.; Allostatic-interoceptive anticipation of social rejection; Academic Press Inc Elsevier Science; Neuroimage; 276; 8-2023; 1-31
1053-8119
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220505
identifier_str_mv Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; et al.; Allostatic-interoceptive anticipation of social rejection; Academic Press Inc Elsevier Science; Neuroimage; 276; 8-2023; 1-31
1053-8119
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1053811923003518?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroimage.2023.120200
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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