Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
- Autores
- Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.
Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina - Materia
-
ANGIOTENSIN II
ANGIOTENSIN RECEPTORS
ANGIOTENSIN-(1-7)
NAD(P)H OXIDASE
OXIDATIVE STRESS
SUPEROXIDE ANION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/162381
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Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide productionPolizio, Ariel HéctorGironacci, Mariela MercedesTomaro, Maria LujanPeña, ClaraANGIOTENSIN IIANGIOTENSIN RECEPTORSANGIOTENSIN-(1-7)NAD(P)H OXIDASEOXIDATIVE STRESSSUPEROXIDE ANIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2007-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162381Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-901043-6618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661807000825info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2007.04.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:27Zoai:ri.conicet.gov.ar:11336/162381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:27.694CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
title |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
spellingShingle |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production Polizio, Ariel Héctor ANGIOTENSIN II ANGIOTENSIN RECEPTORS ANGIOTENSIN-(1-7) NAD(P)H OXIDASE OXIDATIVE STRESS SUPEROXIDE ANION |
title_short |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
title_full |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
title_fullStr |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
title_full_unstemmed |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
title_sort |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production |
dc.creator.none.fl_str_mv |
Polizio, Ariel Héctor Gironacci, Mariela Mercedes Tomaro, Maria Lujan Peña, Clara |
author |
Polizio, Ariel Héctor |
author_facet |
Polizio, Ariel Héctor Gironacci, Mariela Mercedes Tomaro, Maria Lujan Peña, Clara |
author_role |
author |
author2 |
Gironacci, Mariela Mercedes Tomaro, Maria Lujan Peña, Clara |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ANGIOTENSIN II ANGIOTENSIN RECEPTORS ANGIOTENSIN-(1-7) NAD(P)H OXIDASE OXIDATIVE STRESS SUPEROXIDE ANION |
topic |
ANGIOTENSIN II ANGIOTENSIN RECEPTORS ANGIOTENSIN-(1-7) NAD(P)H OXIDASE OXIDATIVE STRESS SUPEROXIDE ANION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development. Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina |
description |
Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/162381 Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-90 1043-6618 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/162381 |
identifier_str_mv |
Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-90 1043-6618 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661807000825 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2007.04.004 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Ltd - Elsevier Science Ltd |
publisher.none.fl_str_mv |
Academic Press Ltd - Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268667723644928 |
score |
13.13397 |