Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production

Autores
Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.
Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
ANGIOTENSIN II
ANGIOTENSIN RECEPTORS
ANGIOTENSIN-(1-7)
NAD(P)H OXIDASE
OXIDATIVE STRESS
SUPEROXIDE ANION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162381

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network_name_str CONICET Digital (CONICET)
spelling Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide productionPolizio, Ariel HéctorGironacci, Mariela MercedesTomaro, Maria LujanPeña, ClaraANGIOTENSIN IIANGIOTENSIN RECEPTORSANGIOTENSIN-(1-7)NAD(P)H OXIDASEOXIDATIVE STRESSSUPEROXIDE ANIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2007-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162381Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-901043-6618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661807000825info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2007.04.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:27Zoai:ri.conicet.gov.ar:11336/162381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:27.694CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
title Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
spellingShingle Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
Polizio, Ariel Héctor
ANGIOTENSIN II
ANGIOTENSIN RECEPTORS
ANGIOTENSIN-(1-7)
NAD(P)H OXIDASE
OXIDATIVE STRESS
SUPEROXIDE ANION
title_short Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
title_full Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
title_fullStr Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
title_full_unstemmed Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
title_sort Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production
dc.creator.none.fl_str_mv Polizio, Ariel Héctor
Gironacci, Mariela Mercedes
Tomaro, Maria Lujan
Peña, Clara
author Polizio, Ariel Héctor
author_facet Polizio, Ariel Héctor
Gironacci, Mariela Mercedes
Tomaro, Maria Lujan
Peña, Clara
author_role author
author2 Gironacci, Mariela Mercedes
Tomaro, Maria Lujan
Peña, Clara
author2_role author
author
author
dc.subject.none.fl_str_mv ANGIOTENSIN II
ANGIOTENSIN RECEPTORS
ANGIOTENSIN-(1-7)
NAD(P)H OXIDASE
OXIDATIVE STRESS
SUPEROXIDE ANION
topic ANGIOTENSIN II
ANGIOTENSIN RECEPTORS
ANGIOTENSIN-(1-7)
NAD(P)H OXIDASE
OXIDATIVE STRESS
SUPEROXIDE ANION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.
Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Peña, Clara. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description Angiotensin (Ang)-(1–7), a bioactive compound of the renin–angiotensin system, exerts effects leading to blood pressure reduction which counterbalance Ang II pressor actions. The present study was conducted to examine Ang-(1–7) and Ang II effects on superoxide anion production in rat aorta using the lucigenin chemiluminescence method. Ang II dose-dependently increased superoxide anion formation when compared tocontrol levels; a maximal increase (2.5-fold) was observed with 1×10−10M peptide concentration. The Ang II-stimulated superoxide formation was blocked by 1×10−10M losartan, the specific AT1 receptor antagonist, but not by 1×10−10M PD 123319, the AT2 receptor antagonist, suggesting that the increased superoxide levels caused by Ang II are mediated through AT1 receptors activation. The Ang II-stimulated superoxideproductionwas not modified by 2×10−8Mallopurinol or 1×10−7Mindomethacin, but was completely abolished byNAD(P)H oxidase inhibitors: 1×10−8M diphenylene iodonium, or 2×10−8M apocynin, demonstrating that NAD(P)H oxidase participates in such response.In contrast to Ang II, Ang-(1–7) concentrations ranging 1×10−12 to 1×10−6M did not modify superoxide anion levels, but prevented the Ang II-enhanced superoxide production. In conclusion, we demonstrated that Ang-(1–7) blocks the pro-oxidant effects of Ang II, thus reducing the superoxide anion production and delaying the hypertension development.
publishDate 2007
dc.date.none.fl_str_mv 2007-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162381
Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-90
1043-6618
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162381
identifier_str_mv Polizio, Ariel Héctor; Gironacci, Mariela Mercedes; Tomaro, Maria Lujan; Peña, Clara; Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 56; 1; 7-2007; 86-90
1043-6618
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661807000825
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2007.04.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
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application/pdf
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dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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