Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency

Autores
Molina, Veronica Carolina; Medici, Marta Graciela; Taranto, Maria Pia; Font, Graciela Maria
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: To evaluate the efficiency of the vitamin B12-producing Lactobacillus reuteri CRL1098 strain in preventing the symptoms caused by a nutritional cobalamin-deficient diet in pregnant female mice and their weaned offspring. Methods and Results: Pregnant female mice were divided into three groups: animals fed with a B12-deficient diet (DD), animals fed with DD plus L. reuteri CRL1098 and animals fed with a B12-sufficient diet. The animals received the different feedings from the end of gestation up to weaning. At the end of the trials, they and their corresponding offspring were bled to determine haematological, immunological and histological parameters. The administration of the pseudovitamin B12-producing strain prevented the symptoms observed in female and weaned young animals fed with a nutritional B12-deficient diet. Conclusions: Our data suggest that the pseudovitamin B12 produced by L. reuteri CRL1098 is biologically active and effective in preventing the pathologies caused by the nutritional deficiency of B12 both in pregnant mice and their offspring. Significance and Impact of the Study: The ability of L. reuteri CRL1098 to prevent a nutritional vitamin deficiency was demonstrated for the first time. The addition of a GRAS micro-organism to complement the B 12 content in deficient foods is an interesting biotechnological alternative.
Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Lactobacillus Reuteri
Mice
Nutritional Deficiency
Pregnancy
Vitamin B 12
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54860
Acceder
id CONICETDig_c272a854f03931f192780c1f959faa37
oai_identifier_str oai:ri.conicet.gov.ar:11336/54860
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiencyMolina, Veronica CarolinaMedici, Marta GracielaTaranto, Maria PiaFont, Graciela MariaLactobacillus ReuteriMiceNutritional DeficiencyPregnancyVitamin B 12https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Aims: To evaluate the efficiency of the vitamin B12-producing Lactobacillus reuteri CRL1098 strain in preventing the symptoms caused by a nutritional cobalamin-deficient diet in pregnant female mice and their weaned offspring. Methods and Results: Pregnant female mice were divided into three groups: animals fed with a B12-deficient diet (DD), animals fed with DD plus L. reuteri CRL1098 and animals fed with a B12-sufficient diet. The animals received the different feedings from the end of gestation up to weaning. At the end of the trials, they and their corresponding offspring were bled to determine haematological, immunological and histological parameters. The administration of the pseudovitamin B12-producing strain prevented the symptoms observed in female and weaned young animals fed with a nutritional B12-deficient diet. Conclusions: Our data suggest that the pseudovitamin B12 produced by L. reuteri CRL1098 is biologically active and effective in preventing the pathologies caused by the nutritional deficiency of B12 both in pregnant mice and their offspring. Significance and Impact of the Study: The ability of L. reuteri CRL1098 to prevent a nutritional vitamin deficiency was demonstrated for the first time. The addition of a GRAS micro-organism to complement the B 12 content in deficient foods is an interesting biotechnological alternative.Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaWiley Blackwell Publishing, Inc2009-02-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54860Molina, Veronica Carolina; Medici, Marta Graciela; Taranto, Maria Pia; Font, Graciela Maria; Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 106; 2; 25-2-2009; 467-4731364-50721365-2672CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2672.2008.04014.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2672.2008.04014.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:57Zoai:ri.conicet.gov.ar:11336/54860instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:57.843CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
title Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
spellingShingle Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
Molina, Veronica Carolina
Lactobacillus Reuteri
Mice
Nutritional Deficiency
Pregnancy
Vitamin B 12
title_short Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
title_full Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
title_fullStr Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
title_full_unstemmed Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
title_sort Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
dc.creator.none.fl_str_mv Molina, Veronica Carolina
Medici, Marta Graciela
Taranto, Maria Pia
Font, Graciela Maria
author Molina, Veronica Carolina
author_facet Molina, Veronica Carolina
Medici, Marta Graciela
Taranto, Maria Pia
Font, Graciela Maria
author_role author
author2 Medici, Marta Graciela
Taranto, Maria Pia
Font, Graciela Maria
author2_role author
author
author
dc.subject.none.fl_str_mv Lactobacillus Reuteri
Mice
Nutritional Deficiency
Pregnancy
Vitamin B 12
topic Lactobacillus Reuteri
Mice
Nutritional Deficiency
Pregnancy
Vitamin B 12
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aims: To evaluate the efficiency of the vitamin B12-producing Lactobacillus reuteri CRL1098 strain in preventing the symptoms caused by a nutritional cobalamin-deficient diet in pregnant female mice and their weaned offspring. Methods and Results: Pregnant female mice were divided into three groups: animals fed with a B12-deficient diet (DD), animals fed with DD plus L. reuteri CRL1098 and animals fed with a B12-sufficient diet. The animals received the different feedings from the end of gestation up to weaning. At the end of the trials, they and their corresponding offspring were bled to determine haematological, immunological and histological parameters. The administration of the pseudovitamin B12-producing strain prevented the symptoms observed in female and weaned young animals fed with a nutritional B12-deficient diet. Conclusions: Our data suggest that the pseudovitamin B12 produced by L. reuteri CRL1098 is biologically active and effective in preventing the pathologies caused by the nutritional deficiency of B12 both in pregnant mice and their offspring. Significance and Impact of the Study: The ability of L. reuteri CRL1098 to prevent a nutritional vitamin deficiency was demonstrated for the first time. The addition of a GRAS micro-organism to complement the B 12 content in deficient foods is an interesting biotechnological alternative.
Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Aims: To evaluate the efficiency of the vitamin B12-producing Lactobacillus reuteri CRL1098 strain in preventing the symptoms caused by a nutritional cobalamin-deficient diet in pregnant female mice and their weaned offspring. Methods and Results: Pregnant female mice were divided into three groups: animals fed with a B12-deficient diet (DD), animals fed with DD plus L. reuteri CRL1098 and animals fed with a B12-sufficient diet. The animals received the different feedings from the end of gestation up to weaning. At the end of the trials, they and their corresponding offspring were bled to determine haematological, immunological and histological parameters. The administration of the pseudovitamin B12-producing strain prevented the symptoms observed in female and weaned young animals fed with a nutritional B12-deficient diet. Conclusions: Our data suggest that the pseudovitamin B12 produced by L. reuteri CRL1098 is biologically active and effective in preventing the pathologies caused by the nutritional deficiency of B12 both in pregnant mice and their offspring. Significance and Impact of the Study: The ability of L. reuteri CRL1098 to prevent a nutritional vitamin deficiency was demonstrated for the first time. The addition of a GRAS micro-organism to complement the B 12 content in deficient foods is an interesting biotechnological alternative.
publishDate 2009
dc.date.none.fl_str_mv 2009-02-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54860
Molina, Veronica Carolina; Medici, Marta Graciela; Taranto, Maria Pia; Font, Graciela Maria; Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 106; 2; 25-2-2009; 467-473
1364-5072
1365-2672
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54860
identifier_str_mv Molina, Veronica Carolina; Medici, Marta Graciela; Taranto, Maria Pia; Font, Graciela Maria; Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 106; 2; 25-2-2009; 467-473
1364-5072
1365-2672
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2672.2008.04014.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2672.2008.04014.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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