The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease

Autores
Tarleton, Rick L.; Saunders, Ashley B.; Lococo, Bruno Edgardo; Alvarez Gianni, Maria Gabriela; Laucella, Susana Adriana; Hodo, Carolyn L.; Wilkerson, Gregory K.; Hamer, Sarah A.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, iswidely distributed in many vertebrate and triatomine species throughout North,Central, and South America. Variations in housing quality largely determineshuman infection risk in the Americas. However, the southern U.S. containswidespread, infected triatomine vectors and captive species and domesticatedanimals with active T. cruzi infection or at high risk of becoming infected anddeveloping Chagas disease. There is a critical need for better detection andintervention strategies, principally focused on human infection throughout theAmericas, but mainly in the U.S., for high-value dogs employed in governmentand other work. In addition to this economic impact, the concentration oflargely unavoidable T. cruzi infections in U.S. dogs provides an incomparableopportunity to answer questions related to T. cruzi infection and Chagasdisease that are impossible or unethical to address in humans. As the course ofT. cruzi infection and Chagas disease, the immune response to infection, andthe response to therapeutics are highly similar across the range of mammalianhost species, information obtained from studies in other species can directlyinform researchers on how to best detect, manage, and treat T. cruzi infectionand Chagas disease in humans.
Fil: Tarleton, Rick L.. University of Georgia; Estados Unidos
Fil: Saunders, Ashley B.. Texas A&M University; Estados Unidos
Fil: Lococo, Bruno Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Alvarez Gianni, Maria Gabriela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Hodo, Carolyn L.. University of Texas; Estados Unidos
Fil: Wilkerson, Gregory K.. University of North Carolina; Estados Unidos
Fil: Hamer, Sarah A.. Texas A&M University; Estados Unidos
Materia
TRYPANOSOMA CRUZI
CHAGAS
CONTROL
PHISIOPATHOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280303
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas DiseaseTarleton, Rick L.Saunders, Ashley B.Lococo, Bruno EdgardoAlvarez Gianni, Maria GabrielaLaucella, Susana AdrianaHodo, Carolyn L.Wilkerson, Gregory K.Hamer, Sarah A.TRYPANOSOMA CRUZICHAGASCONTROLPHISIOPATHOLOGYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, iswidely distributed in many vertebrate and triatomine species throughout North,Central, and South America. Variations in housing quality largely determineshuman infection risk in the Americas. However, the southern U.S. containswidespread, infected triatomine vectors and captive species and domesticatedanimals with active T. cruzi infection or at high risk of becoming infected anddeveloping Chagas disease. There is a critical need for better detection andintervention strategies, principally focused on human infection throughout theAmericas, but mainly in the U.S., for high-value dogs employed in governmentand other work. In addition to this economic impact, the concentration oflargely unavoidable T. cruzi infections in U.S. dogs provides an incomparableopportunity to answer questions related to T. cruzi infection and Chagasdisease that are impossible or unethical to address in humans. As the course ofT. cruzi infection and Chagas disease, the immune response to infection, andthe response to therapeutics are highly similar across the range of mammalianhost species, information obtained from studies in other species can directlyinform researchers on how to best detect, manage, and treat T. cruzi infectionand Chagas disease in humans.Fil: Tarleton, Rick L.. University of Georgia; Estados UnidosFil: Saunders, Ashley B.. Texas A&M University; Estados UnidosFil: Lococo, Bruno Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Alvarez Gianni, Maria Gabriela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Hodo, Carolyn L.. University of Texas; Estados UnidosFil: Wilkerson, Gregory K.. University of North Carolina; Estados UnidosFil: Hamer, Sarah A.. Texas A&M University; Estados UnidosScienceOpen2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280303Tarleton, Rick L.; Saunders, Ashley B.; Lococo, Bruno Edgardo; Alvarez Gianni, Maria Gabriela; Laucella, Susana Adriana; et al.; The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease; ScienceOpen; Zoonoses; 4; 1; 4-2024; 1-52737-74662737-7474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0005info:eu-repo/semantics/altIdentifier/doi/10.15212/ZOONOSES-2024-0005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:06:30Zoai:ri.conicet.gov.ar:11336/280303instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:06:31.066CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
title The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
spellingShingle The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
Tarleton, Rick L.
TRYPANOSOMA CRUZI
CHAGAS
CONTROL
PHISIOPATHOLOGY
title_short The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
title_full The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
title_fullStr The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
title_full_unstemmed The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
title_sort The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
dc.creator.none.fl_str_mv Tarleton, Rick L.
Saunders, Ashley B.
Lococo, Bruno Edgardo
Alvarez Gianni, Maria Gabriela
Laucella, Susana Adriana
Hodo, Carolyn L.
Wilkerson, Gregory K.
Hamer, Sarah A.
author Tarleton, Rick L.
author_facet Tarleton, Rick L.
Saunders, Ashley B.
Lococo, Bruno Edgardo
Alvarez Gianni, Maria Gabriela
Laucella, Susana Adriana
Hodo, Carolyn L.
Wilkerson, Gregory K.
Hamer, Sarah A.
author_role author
author2 Saunders, Ashley B.
Lococo, Bruno Edgardo
Alvarez Gianni, Maria Gabriela
Laucella, Susana Adriana
Hodo, Carolyn L.
Wilkerson, Gregory K.
Hamer, Sarah A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TRYPANOSOMA CRUZI
CHAGAS
CONTROL
PHISIOPATHOLOGY
topic TRYPANOSOMA CRUZI
CHAGAS
CONTROL
PHISIOPATHOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, iswidely distributed in many vertebrate and triatomine species throughout North,Central, and South America. Variations in housing quality largely determineshuman infection risk in the Americas. However, the southern U.S. containswidespread, infected triatomine vectors and captive species and domesticatedanimals with active T. cruzi infection or at high risk of becoming infected anddeveloping Chagas disease. There is a critical need for better detection andintervention strategies, principally focused on human infection throughout theAmericas, but mainly in the U.S., for high-value dogs employed in governmentand other work. In addition to this economic impact, the concentration oflargely unavoidable T. cruzi infections in U.S. dogs provides an incomparableopportunity to answer questions related to T. cruzi infection and Chagasdisease that are impossible or unethical to address in humans. As the course ofT. cruzi infection and Chagas disease, the immune response to infection, andthe response to therapeutics are highly similar across the range of mammalianhost species, information obtained from studies in other species can directlyinform researchers on how to best detect, manage, and treat T. cruzi infectionand Chagas disease in humans.
Fil: Tarleton, Rick L.. University of Georgia; Estados Unidos
Fil: Saunders, Ashley B.. Texas A&M University; Estados Unidos
Fil: Lococo, Bruno Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Alvarez Gianni, Maria Gabriela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Hodo, Carolyn L.. University of Texas; Estados Unidos
Fil: Wilkerson, Gregory K.. University of North Carolina; Estados Unidos
Fil: Hamer, Sarah A.. Texas A&M University; Estados Unidos
description Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, iswidely distributed in many vertebrate and triatomine species throughout North,Central, and South America. Variations in housing quality largely determineshuman infection risk in the Americas. However, the southern U.S. containswidespread, infected triatomine vectors and captive species and domesticatedanimals with active T. cruzi infection or at high risk of becoming infected anddeveloping Chagas disease. There is a critical need for better detection andintervention strategies, principally focused on human infection throughout theAmericas, but mainly in the U.S., for high-value dogs employed in governmentand other work. In addition to this economic impact, the concentration oflargely unavoidable T. cruzi infections in U.S. dogs provides an incomparableopportunity to answer questions related to T. cruzi infection and Chagasdisease that are impossible or unethical to address in humans. As the course ofT. cruzi infection and Chagas disease, the immune response to infection, andthe response to therapeutics are highly similar across the range of mammalianhost species, information obtained from studies in other species can directlyinform researchers on how to best detect, manage, and treat T. cruzi infectionand Chagas disease in humans.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280303
Tarleton, Rick L.; Saunders, Ashley B.; Lococo, Bruno Edgardo; Alvarez Gianni, Maria Gabriela; Laucella, Susana Adriana; et al.; The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease; ScienceOpen; Zoonoses; 4; 1; 4-2024; 1-5
2737-7466
2737-7474
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280303
identifier_str_mv Tarleton, Rick L.; Saunders, Ashley B.; Lococo, Bruno Edgardo; Alvarez Gianni, Maria Gabriela; Laucella, Susana Adriana; et al.; The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease; ScienceOpen; Zoonoses; 4; 1; 4-2024; 1-5
2737-7466
2737-7474
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0005
info:eu-repo/semantics/altIdentifier/doi/10.15212/ZOONOSES-2024-0005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ScienceOpen
publisher.none.fl_str_mv ScienceOpen
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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