Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents

Autores
Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; Cruz, Uriel Mora; Enriz, Ricardo Daniel
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombia
Fil: Vargas M, Leonor Y.. Universidad Industrial Santander; Colombia
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Cruz, Uriel Mora. Universidad Industrial Santander; Colombia
Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
ANTIFUNGAL ACTIVITY
HOMOALLYLAMINES
SAR
SYNTHESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138702

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spelling Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agentsSuvire, Fernando DanielSortino, Maximiliano AndrésKouznetsov, Vladimir V.Vargas M, Leonor Y.Zacchino, Susana Alicia StellaCruz, Uriel MoraEnriz, Ricardo DanielANTIFUNGAL ACTIVITYHOMOALLYLAMINESSARSYNTHESIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; ColombiaFil: Vargas M, Leonor Y.. Universidad Industrial Santander; ColombiaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Cruz, Uriel Mora. Universidad Industrial Santander; ColombiaFil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaElsevier2006-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138702Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-18620968-0896CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0968089605010230info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2005.10.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:09Zoai:ri.conicet.gov.ar:11336/138702instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:09.948CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
title Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
spellingShingle Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
Suvire, Fernando Daniel
ANTIFUNGAL ACTIVITY
HOMOALLYLAMINES
SAR
SYNTHESIS
title_short Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
title_full Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
title_fullStr Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
title_full_unstemmed Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
title_sort Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
dc.creator.none.fl_str_mv Suvire, Fernando Daniel
Sortino, Maximiliano Andrés
Kouznetsov, Vladimir V.
Vargas M, Leonor Y.
Zacchino, Susana Alicia Stella
Cruz, Uriel Mora
Enriz, Ricardo Daniel
author Suvire, Fernando Daniel
author_facet Suvire, Fernando Daniel
Sortino, Maximiliano Andrés
Kouznetsov, Vladimir V.
Vargas M, Leonor Y.
Zacchino, Susana Alicia Stella
Cruz, Uriel Mora
Enriz, Ricardo Daniel
author_role author
author2 Sortino, Maximiliano Andrés
Kouznetsov, Vladimir V.
Vargas M, Leonor Y.
Zacchino, Susana Alicia Stella
Cruz, Uriel Mora
Enriz, Ricardo Daniel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL ACTIVITY
HOMOALLYLAMINES
SAR
SYNTHESIS
topic ANTIFUNGAL ACTIVITY
HOMOALLYLAMINES
SAR
SYNTHESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombia
Fil: Vargas M, Leonor Y.. Universidad Industrial Santander; Colombia
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Cruz, Uriel Mora. Universidad Industrial Santander; Colombia
Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138702
Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862
0968-0896
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138702
identifier_str_mv Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862
0968-0896
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0968089605010230
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2005.10.036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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