Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
- Autores
- Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; Cruz, Uriel Mora; Enriz, Ricardo Daniel
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombia
Fil: Vargas M, Leonor Y.. Universidad Industrial Santander; Colombia
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Cruz, Uriel Mora. Universidad Industrial Santander; Colombia
Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina - Materia
-
ANTIFUNGAL ACTIVITY
HOMOALLYLAMINES
SAR
SYNTHESIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/138702
Ver los metadatos del registro completo
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Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agentsSuvire, Fernando DanielSortino, Maximiliano AndrésKouznetsov, Vladimir V.Vargas M, Leonor Y.Zacchino, Susana Alicia StellaCruz, Uriel MoraEnriz, Ricardo DanielANTIFUNGAL ACTIVITYHOMOALLYLAMINESSARSYNTHESIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; ColombiaFil: Vargas M, Leonor Y.. Universidad Industrial Santander; ColombiaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Cruz, Uriel Mora. Universidad Industrial Santander; ColombiaFil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaElsevier2006-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138702Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-18620968-0896CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0968089605010230info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2005.10.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:09Zoai:ri.conicet.gov.ar:11336/138702instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:09.948CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
title |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
spellingShingle |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents Suvire, Fernando Daniel ANTIFUNGAL ACTIVITY HOMOALLYLAMINES SAR SYNTHESIS |
title_short |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
title_full |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
title_fullStr |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
title_full_unstemmed |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
title_sort |
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
dc.creator.none.fl_str_mv |
Suvire, Fernando Daniel Sortino, Maximiliano Andrés Kouznetsov, Vladimir V. Vargas M, Leonor Y. Zacchino, Susana Alicia Stella Cruz, Uriel Mora Enriz, Ricardo Daniel |
author |
Suvire, Fernando Daniel |
author_facet |
Suvire, Fernando Daniel Sortino, Maximiliano Andrés Kouznetsov, Vladimir V. Vargas M, Leonor Y. Zacchino, Susana Alicia Stella Cruz, Uriel Mora Enriz, Ricardo Daniel |
author_role |
author |
author2 |
Sortino, Maximiliano Andrés Kouznetsov, Vladimir V. Vargas M, Leonor Y. Zacchino, Susana Alicia Stella Cruz, Uriel Mora Enriz, Ricardo Daniel |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ANTIFUNGAL ACTIVITY HOMOALLYLAMINES SAR SYNTHESIS |
topic |
ANTIFUNGAL ACTIVITY HOMOALLYLAMINES SAR SYNTHESIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties. Fil: Suvire, Fernando Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombia Fil: Vargas M, Leonor Y.. Universidad Industrial Santander; Colombia Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina Fil: Cruz, Uriel Mora. Universidad Industrial Santander; Colombia Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina |
description |
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-03-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/138702 Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862 0968-0896 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/138702 |
identifier_str_mv |
Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862 0968-0896 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0968089605010230 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2005.10.036 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614066208768000 |
score |
13.070432 |