Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo

Autores
Andres, Daniela Sabrina; Cerquetti, Daniel; Merello, Marcelo Jorge; Stoop, Ruedi
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described. We recorded the activity of single globus pallidus pars interna neurons during the transition from deep anesthesia to full alertness in relaxed, head-restrained, control, and parkinsonian (6-hydroxydopamine-lesioned group-lesioned) rats. We found that during awakening from anesthesia, the variation of neuronal entropy was significantly higher in the parkinsonian than in the control group. This implies in our view that in PD the entropy of the output neurons of the BG varies dynamically with the input to the network, which is determined by the level of alertness. Therefore, entropy needs to be interpreted as a dynamic, emergent property that characterizes the global state of the BG neuronal network, rather than a static property of parkinsonian neurons themselves. Within the framework of the "entropy hypothesis," this implies the presence of a pathological feedback loop in the parkinsonian BG, where increasing the network input results in a further increase of neuronal entropy and a worsening of akinesia.
Fil: Andres, Daniela Sabrina. Universitat Zurich; Suiza. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cerquetti, Daniel. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stoop, Ruedi. Universitat Zurich; Suiza
Materia
Alertness
Basal Ganglia
Emergent Properties
Entropy
Non-Linear
Parkinson'S Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38499
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivoAndres, Daniela SabrinaCerquetti, DanielMerello, Marcelo JorgeStoop, RuediAlertnessBasal GangliaEmergent PropertiesEntropyNon-LinearParkinson'S Diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described. We recorded the activity of single globus pallidus pars interna neurons during the transition from deep anesthesia to full alertness in relaxed, head-restrained, control, and parkinsonian (6-hydroxydopamine-lesioned group-lesioned) rats. We found that during awakening from anesthesia, the variation of neuronal entropy was significantly higher in the parkinsonian than in the control group. This implies in our view that in PD the entropy of the output neurons of the BG varies dynamically with the input to the network, which is determined by the level of alertness. Therefore, entropy needs to be interpreted as a dynamic, emergent property that characterizes the global state of the BG neuronal network, rather than a static property of parkinsonian neurons themselves. Within the framework of the "entropy hypothesis," this implies the presence of a pathological feedback loop in the parkinsonian BG, where increasing the network input results in a further increase of neuronal entropy and a worsening of akinesia.Fil: Andres, Daniela Sabrina. Universitat Zurich; Suiza. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cerquetti, Daniel. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; ArgentinaFil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Stoop, Ruedi. Universitat Zurich; SuizaFrontiers2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38499Andres, Daniela Sabrina; Cerquetti, Daniel; Merello, Marcelo Jorge; Stoop, Ruedi; Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo; Frontiers; Frontiers in Neurology; 5; 6-2014; 1-9; 961664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2014.00096info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2014.00096/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:23:58Zoai:ri.conicet.gov.ar:11336/38499instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:23:58.24CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
title Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
spellingShingle Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
Andres, Daniela Sabrina
Alertness
Basal Ganglia
Emergent Properties
Entropy
Non-Linear
Parkinson'S Disease
title_short Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
title_full Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
title_fullStr Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
title_full_unstemmed Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
title_sort Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo
dc.creator.none.fl_str_mv Andres, Daniela Sabrina
Cerquetti, Daniel
Merello, Marcelo Jorge
Stoop, Ruedi
author Andres, Daniela Sabrina
author_facet Andres, Daniela Sabrina
Cerquetti, Daniel
Merello, Marcelo Jorge
Stoop, Ruedi
author_role author
author2 Cerquetti, Daniel
Merello, Marcelo Jorge
Stoop, Ruedi
author2_role author
author
author
dc.subject.none.fl_str_mv Alertness
Basal Ganglia
Emergent Properties
Entropy
Non-Linear
Parkinson'S Disease
topic Alertness
Basal Ganglia
Emergent Properties
Entropy
Non-Linear
Parkinson'S Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described. We recorded the activity of single globus pallidus pars interna neurons during the transition from deep anesthesia to full alertness in relaxed, head-restrained, control, and parkinsonian (6-hydroxydopamine-lesioned group-lesioned) rats. We found that during awakening from anesthesia, the variation of neuronal entropy was significantly higher in the parkinsonian than in the control group. This implies in our view that in PD the entropy of the output neurons of the BG varies dynamically with the input to the network, which is determined by the level of alertness. Therefore, entropy needs to be interpreted as a dynamic, emergent property that characterizes the global state of the BG neuronal network, rather than a static property of parkinsonian neurons themselves. Within the framework of the "entropy hypothesis," this implies the presence of a pathological feedback loop in the parkinsonian BG, where increasing the network input results in a further increase of neuronal entropy and a worsening of akinesia.
Fil: Andres, Daniela Sabrina. Universitat Zurich; Suiza. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cerquetti, Daniel. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stoop, Ruedi. Universitat Zurich; Suiza
description A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described. We recorded the activity of single globus pallidus pars interna neurons during the transition from deep anesthesia to full alertness in relaxed, head-restrained, control, and parkinsonian (6-hydroxydopamine-lesioned group-lesioned) rats. We found that during awakening from anesthesia, the variation of neuronal entropy was significantly higher in the parkinsonian than in the control group. This implies in our view that in PD the entropy of the output neurons of the BG varies dynamically with the input to the network, which is determined by the level of alertness. Therefore, entropy needs to be interpreted as a dynamic, emergent property that characterizes the global state of the BG neuronal network, rather than a static property of parkinsonian neurons themselves. Within the framework of the "entropy hypothesis," this implies the presence of a pathological feedback loop in the parkinsonian BG, where increasing the network input results in a further increase of neuronal entropy and a worsening of akinesia.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38499
Andres, Daniela Sabrina; Cerquetti, Daniel; Merello, Marcelo Jorge; Stoop, Ruedi; Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo; Frontiers; Frontiers in Neurology; 5; 6-2014; 1-9; 96
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38499
identifier_str_mv Andres, Daniela Sabrina; Cerquetti, Daniel; Merello, Marcelo Jorge; Stoop, Ruedi; Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo; Frontiers; Frontiers in Neurology; 5; 6-2014; 1-9; 96
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2014.00096
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2014.00096/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.229304

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