Alterations in time estimation in multiple system atrophy

Autores
Hogl, Birgit; Agostino, Patricia; Peralta, Maria Cecilia; Gershanik, Oscar Samuel; Golombek, Diego Andrés
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Precise spatiotemporal performance is required by many common tasks and represents a basic aspect of cognition. Time estimation in the second-to-minutes range – known as interval timing – involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic–glutamatergic pathways. Neurodegenerative disorders such as Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized by basal ganglia dysfunction due to dopamine loss. Although interval timing in PD has been studied, little is known about temporal processing in MSA. In the present work, control, PD and MSA subjects (n = 8 for each group) were tested for interval timing in short (<5 s), medium (5–15 s) and long (>15 s) duration stimuli. MSA differed significantly from controls and PD patients in terms of decreased accuracy in the timing task. Differences between PD and MSA patients (as well as between MSA and controls) were lost after levodopa treatment. We show that time estimation for time bins between 5 and 20 s is affected in subjects with MSA, who had a significant tendency to underestimate time intervals as compared to controls or PD patients. Recordings of cognitive performance related to timing could be considered useful measurements of the progression of movement disorder-related pathologies
Fil: Hogl, Birgit. Universidad de Innsbruck; Austria
Fil: Agostino, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Peralta, Maria Cecilia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Gershanik, Oscar Samuel. Fundación Favaloro; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Materia
Basal Ganglia
Dopamine
Multiple System Atrophy
Parkinson'S Disease
Time Estimation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/35692
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/35692
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alterations in time estimation in multiple system atrophyHogl, BirgitAgostino, PatriciaPeralta, Maria CeciliaGershanik, Oscar SamuelGolombek, Diego AndrésBasal GangliaDopamineMultiple System AtrophyParkinson'S DiseaseTime Estimationhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Precise spatiotemporal performance is required by many common tasks and represents a basic aspect of cognition. Time estimation in the second-to-minutes range – known as interval timing – involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic–glutamatergic pathways. Neurodegenerative disorders such as Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized by basal ganglia dysfunction due to dopamine loss. Although interval timing in PD has been studied, little is known about temporal processing in MSA. In the present work, control, PD and MSA subjects (n = 8 for each group) were tested for interval timing in short (<5 s), medium (5–15 s) and long (>15 s) duration stimuli. MSA differed significantly from controls and PD patients in terms of decreased accuracy in the timing task. Differences between PD and MSA patients (as well as between MSA and controls) were lost after levodopa treatment. We show that time estimation for time bins between 5 and 20 s is affected in subjects with MSA, who had a significant tendency to underestimate time intervals as compared to controls or PD patients. Recordings of cognitive performance related to timing could be considered useful measurements of the progression of movement disorder-related pathologiesFil: Hogl, Birgit. Universidad de Innsbruck; AustriaFil: Agostino, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Peralta, Maria Cecilia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Gershanik, Oscar Samuel. Fundación Favaloro; ArgentinaFil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaElsevier2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/35692Hogl, Birgit; Agostino, Patricia; Peralta, Maria Cecilia; Gershanik, Oscar Samuel; Golombek, Diego Andrés; Alterations in time estimation in multiple system atrophy; Elsevier; Basal Ganglia; 4; 3-4; 6-2014; 95-992210-5336CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.baga.2014.06.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210533614000525info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:25Zoai:ri.conicet.gov.ar:11336/35692instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:25.952CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alterations in time estimation in multiple system atrophy
title Alterations in time estimation in multiple system atrophy
spellingShingle Alterations in time estimation in multiple system atrophy
Hogl, Birgit
Basal Ganglia
Dopamine
Multiple System Atrophy
Parkinson'S Disease
Time Estimation
title_short Alterations in time estimation in multiple system atrophy
title_full Alterations in time estimation in multiple system atrophy
title_fullStr Alterations in time estimation in multiple system atrophy
title_full_unstemmed Alterations in time estimation in multiple system atrophy
title_sort Alterations in time estimation in multiple system atrophy
dc.creator.none.fl_str_mv Hogl, Birgit
Agostino, Patricia
Peralta, Maria Cecilia
Gershanik, Oscar Samuel
Golombek, Diego Andrés
author Hogl, Birgit
author_facet Hogl, Birgit
Agostino, Patricia
Peralta, Maria Cecilia
Gershanik, Oscar Samuel
Golombek, Diego Andrés
author_role author
author2 Agostino, Patricia
Peralta, Maria Cecilia
Gershanik, Oscar Samuel
Golombek, Diego Andrés
author2_role author
author
author
author
dc.subject.none.fl_str_mv Basal Ganglia
Dopamine
Multiple System Atrophy
Parkinson'S Disease
Time Estimation
topic Basal Ganglia
Dopamine
Multiple System Atrophy
Parkinson'S Disease
Time Estimation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Precise spatiotemporal performance is required by many common tasks and represents a basic aspect of cognition. Time estimation in the second-to-minutes range – known as interval timing – involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic–glutamatergic pathways. Neurodegenerative disorders such as Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized by basal ganglia dysfunction due to dopamine loss. Although interval timing in PD has been studied, little is known about temporal processing in MSA. In the present work, control, PD and MSA subjects (n = 8 for each group) were tested for interval timing in short (<5 s), medium (5–15 s) and long (>15 s) duration stimuli. MSA differed significantly from controls and PD patients in terms of decreased accuracy in the timing task. Differences between PD and MSA patients (as well as between MSA and controls) were lost after levodopa treatment. We show that time estimation for time bins between 5 and 20 s is affected in subjects with MSA, who had a significant tendency to underestimate time intervals as compared to controls or PD patients. Recordings of cognitive performance related to timing could be considered useful measurements of the progression of movement disorder-related pathologies
Fil: Hogl, Birgit. Universidad de Innsbruck; Austria
Fil: Agostino, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Peralta, Maria Cecilia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Gershanik, Oscar Samuel. Fundación Favaloro; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
description Precise spatiotemporal performance is required by many common tasks and represents a basic aspect of cognition. Time estimation in the second-to-minutes range – known as interval timing – involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic–glutamatergic pathways. Neurodegenerative disorders such as Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized by basal ganglia dysfunction due to dopamine loss. Although interval timing in PD has been studied, little is known about temporal processing in MSA. In the present work, control, PD and MSA subjects (n = 8 for each group) were tested for interval timing in short (<5 s), medium (5–15 s) and long (>15 s) duration stimuli. MSA differed significantly from controls and PD patients in terms of decreased accuracy in the timing task. Differences between PD and MSA patients (as well as between MSA and controls) were lost after levodopa treatment. We show that time estimation for time bins between 5 and 20 s is affected in subjects with MSA, who had a significant tendency to underestimate time intervals as compared to controls or PD patients. Recordings of cognitive performance related to timing could be considered useful measurements of the progression of movement disorder-related pathologies
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/35692
Hogl, Birgit; Agostino, Patricia; Peralta, Maria Cecilia; Gershanik, Oscar Samuel; Golombek, Diego Andrés; Alterations in time estimation in multiple system atrophy; Elsevier; Basal Ganglia; 4; 3-4; 6-2014; 95-99
2210-5336
CONICET Digital
CONICET
url http://hdl.handle.net/11336/35692
identifier_str_mv Hogl, Birgit; Agostino, Patricia; Peralta, Maria Cecilia; Gershanik, Oscar Samuel; Golombek, Diego Andrés; Alterations in time estimation in multiple system atrophy; Elsevier; Basal Ganglia; 4; 3-4; 6-2014; 95-99
2210-5336
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.baga.2014.06.004
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210533614000525
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270044262760448
score 13.13397

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