Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery

Autores
Chevalier, Merari Tumin; Rescignano, Nicoletta; Martin Saldaña, Sergio; González Gómez, Álvaro; Kenny, José Maria; San Román, Julio; Mijangos, Carmen; Alvarez, Vera Alejandra
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.
Fil: Chevalier, Merari Tumin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Rescignano, Nicoletta. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Martin Saldaña, Sergio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: González Gómez, Álvaro. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Kenny, José Maria. Università di Perugia; Italia
Fil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Mijangos, Carmen. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
CELL VIABILITY
DRUG DELIVERY
NANOPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
POLYLYSINE
TAMOXIFEN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44311
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/44311
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Non-covalently coated biopolymeric nanoparticles for improved tamoxifen deliveryChevalier, Merari TuminRescignano, NicolettaMartin Saldaña, SergioGonzález Gómez, ÁlvaroKenny, José MariaSan Román, JulioMijangos, CarmenAlvarez, Vera AlejandraCELL VIABILITYDRUG DELIVERYNANOPARTICLESPOLY(LACTIC-CO-GLYCOLIC ACID)POLYLYSINETAMOXIFENhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.Fil: Chevalier, Merari Tumin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Rescignano, Nicoletta. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Martin Saldaña, Sergio. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: González Gómez, Álvaro. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Kenny, José Maria. Università di Perugia; ItaliaFil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Mijangos, Carmen. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaPergamon-Elsevier Science Ltd2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44311Chevalier, Merari Tumin; Rescignano, Nicoletta; Martin Saldaña, Sergio; González Gómez, Álvaro; Kenny, José Maria; et al.; Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery; Pergamon-Elsevier Science Ltd; European Polymer Journal; 95; 10-2017; 348-3570014-3057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014305717309515info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2017.08.031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:31Zoai:ri.conicet.gov.ar:11336/44311instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:31.91CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
title Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
spellingShingle Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
Chevalier, Merari Tumin
CELL VIABILITY
DRUG DELIVERY
NANOPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
POLYLYSINE
TAMOXIFEN
title_short Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
title_full Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
title_fullStr Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
title_full_unstemmed Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
title_sort Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
dc.creator.none.fl_str_mv Chevalier, Merari Tumin
Rescignano, Nicoletta
Martin Saldaña, Sergio
González Gómez, Álvaro
Kenny, José Maria
San Román, Julio
Mijangos, Carmen
Alvarez, Vera Alejandra
author Chevalier, Merari Tumin
author_facet Chevalier, Merari Tumin
Rescignano, Nicoletta
Martin Saldaña, Sergio
González Gómez, Álvaro
Kenny, José Maria
San Román, Julio
Mijangos, Carmen
Alvarez, Vera Alejandra
author_role author
author2 Rescignano, Nicoletta
Martin Saldaña, Sergio
González Gómez, Álvaro
Kenny, José Maria
San Román, Julio
Mijangos, Carmen
Alvarez, Vera Alejandra
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CELL VIABILITY
DRUG DELIVERY
NANOPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
POLYLYSINE
TAMOXIFEN
topic CELL VIABILITY
DRUG DELIVERY
NANOPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
POLYLYSINE
TAMOXIFEN
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.
Fil: Chevalier, Merari Tumin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Rescignano, Nicoletta. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Martin Saldaña, Sergio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: González Gómez, Álvaro. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Kenny, José Maria. Università di Perugia; Italia
Fil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Mijangos, Carmen. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44311
Chevalier, Merari Tumin; Rescignano, Nicoletta; Martin Saldaña, Sergio; González Gómez, Álvaro; Kenny, José Maria; et al.; Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery; Pergamon-Elsevier Science Ltd; European Polymer Journal; 95; 10-2017; 348-357
0014-3057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44311
identifier_str_mv Chevalier, Merari Tumin; Rescignano, Nicoletta; Martin Saldaña, Sergio; González Gómez, Álvaro; Kenny, José Maria; et al.; Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery; Pergamon-Elsevier Science Ltd; European Polymer Journal; 95; 10-2017; 348-357
0014-3057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014305717309515
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2017.08.031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269915168374784
score 13.13397

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