Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy

Autores
Martín Giménez, Virna Margarita; Modrego, Javier; Gómez Garre, Dulcenombre; Manucha, Walter Ariel Fernando; de Las Heras, Natalia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition of patients´ gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interestingly, certain strains of these bacteria produce metabolites that can target the S protein of other coronaviruses, thereby preventing their trans-mission and harmful effects. At the same time, the presence of gut dysbiosis can exacerbate in-flammation and oxidative stress, creating a vicious cycle that perpetuates the disease. Furthermore, it is widely recognized that the gut microbiota can metabolize various foods and drugs, producing by-products that may have either beneficial or detrimental effects. In this regard, a decrease in short-chain fatty acid (SCFA), such as acetate, propionate, and butyrate, can influence the overall inflammatory and oxidative state, affecting the prevention, treatment, or worsening of COVID-19. This review aims to explore the current evidence regarding gut dysbiosis in patients with COVID-19, its association with inflammation and oxidative stress, the molecular mechanisms involved, and the potential of gut microbiota modulation in preventing and treating SARS-CoV-2 infection. Given that gut microbiota has demonstrated high adaptability, exploring ways and strategies to maintain good intestinal health, as well as an appropriate diversity and composition of the gut microbiome, becomes crucial in the battle against COVID-19.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Modrego, Javier. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; España
Fil: Gómez Garre, Dulcenombre. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; España. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Materia
COVID-19
MICROBIOTA
OXIDATIVE STRESS
INFLAMMATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248612
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapyMartín Giménez, Virna MargaritaModrego, JavierGómez Garre, DulcenombreManucha, Walter Ariel Fernandode Las Heras, NataliaCOVID-19MICROBIOTAOXIDATIVE STRESSINFLAMMATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition of patients´ gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interestingly, certain strains of these bacteria produce metabolites that can target the S protein of other coronaviruses, thereby preventing their trans-mission and harmful effects. At the same time, the presence of gut dysbiosis can exacerbate in-flammation and oxidative stress, creating a vicious cycle that perpetuates the disease. Furthermore, it is widely recognized that the gut microbiota can metabolize various foods and drugs, producing by-products that may have either beneficial or detrimental effects. In this regard, a decrease in short-chain fatty acid (SCFA), such as acetate, propionate, and butyrate, can influence the overall inflammatory and oxidative state, affecting the prevention, treatment, or worsening of COVID-19. This review aims to explore the current evidence regarding gut dysbiosis in patients with COVID-19, its association with inflammation and oxidative stress, the molecular mechanisms involved, and the potential of gut microbiota modulation in preventing and treating SARS-CoV-2 infection. Given that gut microbiota has demonstrated high adaptability, exploring ways and strategies to maintain good intestinal health, as well as an appropriate diversity and composition of the gut microbiome, becomes crucial in the battle against COVID-19.Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: Modrego, Javier. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; EspañaFil: Gómez Garre, Dulcenombre. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; España. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; EspañaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; EspañaMolecular Diversity Preservation International2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248612Martín Giménez, Virna Margarita; Modrego, Javier; Gómez Garre, Dulcenombre; Manucha, Walter Ariel Fernando; de Las Heras, Natalia; Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 24; 15; 7-2023; 1-161422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/24/15/12249info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms241512249info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:03:33Zoai:ri.conicet.gov.ar:11336/248612instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:03:33.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
title Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
spellingShingle Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
Martín Giménez, Virna Margarita
COVID-19
MICROBIOTA
OXIDATIVE STRESS
INFLAMMATION
title_short Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
title_full Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
title_fullStr Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
title_full_unstemmed Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
title_sort Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Modrego, Javier
Gómez Garre, Dulcenombre
Manucha, Walter Ariel Fernando
de Las Heras, Natalia
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Modrego, Javier
Gómez Garre, Dulcenombre
Manucha, Walter Ariel Fernando
de Las Heras, Natalia
author_role author
author2 Modrego, Javier
Gómez Garre, Dulcenombre
Manucha, Walter Ariel Fernando
de Las Heras, Natalia
author2_role author
author
author
author
dc.subject.none.fl_str_mv COVID-19
MICROBIOTA
OXIDATIVE STRESS
INFLAMMATION
topic COVID-19
MICROBIOTA
OXIDATIVE STRESS
INFLAMMATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition of patients´ gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interestingly, certain strains of these bacteria produce metabolites that can target the S protein of other coronaviruses, thereby preventing their trans-mission and harmful effects. At the same time, the presence of gut dysbiosis can exacerbate in-flammation and oxidative stress, creating a vicious cycle that perpetuates the disease. Furthermore, it is widely recognized that the gut microbiota can metabolize various foods and drugs, producing by-products that may have either beneficial or detrimental effects. In this regard, a decrease in short-chain fatty acid (SCFA), such as acetate, propionate, and butyrate, can influence the overall inflammatory and oxidative state, affecting the prevention, treatment, or worsening of COVID-19. This review aims to explore the current evidence regarding gut dysbiosis in patients with COVID-19, its association with inflammation and oxidative stress, the molecular mechanisms involved, and the potential of gut microbiota modulation in preventing and treating SARS-CoV-2 infection. Given that gut microbiota has demonstrated high adaptability, exploring ways and strategies to maintain good intestinal health, as well as an appropriate diversity and composition of the gut microbiome, becomes crucial in the battle against COVID-19.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Modrego, Javier. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; España
Fil: Gómez Garre, Dulcenombre. Instituto de Investigación Sanitaria.; España. Instituto de Salud Carlos III; España. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
description Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition of patients´ gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interestingly, certain strains of these bacteria produce metabolites that can target the S protein of other coronaviruses, thereby preventing their trans-mission and harmful effects. At the same time, the presence of gut dysbiosis can exacerbate in-flammation and oxidative stress, creating a vicious cycle that perpetuates the disease. Furthermore, it is widely recognized that the gut microbiota can metabolize various foods and drugs, producing by-products that may have either beneficial or detrimental effects. In this regard, a decrease in short-chain fatty acid (SCFA), such as acetate, propionate, and butyrate, can influence the overall inflammatory and oxidative state, affecting the prevention, treatment, or worsening of COVID-19. This review aims to explore the current evidence regarding gut dysbiosis in patients with COVID-19, its association with inflammation and oxidative stress, the molecular mechanisms involved, and the potential of gut microbiota modulation in preventing and treating SARS-CoV-2 infection. Given that gut microbiota has demonstrated high adaptability, exploring ways and strategies to maintain good intestinal health, as well as an appropriate diversity and composition of the gut microbiome, becomes crucial in the battle against COVID-19.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248612
Martín Giménez, Virna Margarita; Modrego, Javier; Gómez Garre, Dulcenombre; Manucha, Walter Ariel Fernando; de Las Heras, Natalia; Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 24; 15; 7-2023; 1-16
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248612
identifier_str_mv Martín Giménez, Virna Margarita; Modrego, Javier; Gómez Garre, Dulcenombre; Manucha, Walter Ariel Fernando; de Las Heras, Natalia; Gut microbiota dysbiosis in COVID-19: modulation and approaches for prevention and therapy; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 24; 15; 7-2023; 1-16
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/24/15/12249
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms241512249
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.106097

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