Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

Autores
Moya Betancourt, Sara Natalia; Cámara, Candelaria Inés; Riva, Jullieta Soledad
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.
Fil: Moya Betancourt, Sara Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Cámara, Candelaria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Riva, Jullieta Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
BIOMEMBRANE MODELS
CHITOSAN
DICLOFENAC
DIETHYL AMINO-ETHYL DEXTRAN
LANGMUIR MONOLAYER
MAGNETIC NANOPARTICLES
MAXIMUM INSERTION PRESSURE
TRIFLUPROMAZINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226665
Acceder
id CONICETDig_c0ed2057e241dd43c21784896e2449c4
oai_identifier_str oai:ri.conicet.gov.ar:11336/226665
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane ModelsMoya Betancourt, Sara NataliaCámara, Candelaria InésRiva, Jullieta SoledadBIOMEMBRANE MODELSCHITOSANDICLOFENACDIETHYL AMINO-ETHYL DEXTRANLANGMUIR MONOLAYERMAGNETIC NANOPARTICLESMAXIMUM INSERTION PRESSURETRIFLUPROMAZINEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.Fil: Moya Betancourt, Sara Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Cámara, Candelaria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Riva, Jullieta Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaMDPI2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226665Moya Betancourt, Sara Natalia; Cámara, Candelaria Inés; Riva, Jullieta Soledad; Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models; MDPI; Pharmaceutics; 15; 2; 1-2023; 311-3251999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/2/311info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15020311info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:01:46Zoai:ri.conicet.gov.ar:11336/226665instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:01:46.674CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
title Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
spellingShingle Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
Moya Betancourt, Sara Natalia
BIOMEMBRANE MODELS
CHITOSAN
DICLOFENAC
DIETHYL AMINO-ETHYL DEXTRAN
LANGMUIR MONOLAYER
MAGNETIC NANOPARTICLES
MAXIMUM INSERTION PRESSURE
TRIFLUPROMAZINE
title_short Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
title_full Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
title_fullStr Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
title_full_unstemmed Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
title_sort Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
dc.creator.none.fl_str_mv Moya Betancourt, Sara Natalia
Cámara, Candelaria Inés
Riva, Jullieta Soledad
author Moya Betancourt, Sara Natalia
author_facet Moya Betancourt, Sara Natalia
Cámara, Candelaria Inés
Riva, Jullieta Soledad
author_role author
author2 Cámara, Candelaria Inés
Riva, Jullieta Soledad
author2_role author
author
dc.subject.none.fl_str_mv BIOMEMBRANE MODELS
CHITOSAN
DICLOFENAC
DIETHYL AMINO-ETHYL DEXTRAN
LANGMUIR MONOLAYER
MAGNETIC NANOPARTICLES
MAXIMUM INSERTION PRESSURE
TRIFLUPROMAZINE
topic BIOMEMBRANE MODELS
CHITOSAN
DICLOFENAC
DIETHYL AMINO-ETHYL DEXTRAN
LANGMUIR MONOLAYER
MAGNETIC NANOPARTICLES
MAXIMUM INSERTION PRESSURE
TRIFLUPROMAZINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.
Fil: Moya Betancourt, Sara Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Cámara, Candelaria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Riva, Jullieta Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226665
Moya Betancourt, Sara Natalia; Cámara, Candelaria Inés; Riva, Jullieta Soledad; Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models; MDPI; Pharmaceutics; 15; 2; 1-2023; 311-325
1999-4923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226665
identifier_str_mv Moya Betancourt, Sara Natalia; Cámara, Candelaria Inés; Riva, Jullieta Soledad; Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models; MDPI; Pharmaceutics; 15; 2; 1-2023; 311-325
1999-4923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/2/311
info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15020311
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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