Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
- Autores
- Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; Nador, Fabiana Gabriela; Ruiz Molina, Daniel
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; España
Fil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; España
Fil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; España - Materia
-
Mesoporous Silica
Nanoparticles
Polydopamine
Gatekeeping - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/56442
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Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica NanoparticlesMoreno Villaecija, Miguel AngelSedó Vegara, JosepGuisasola Cal, EduardoBaeza, AlejandroVallet Regí, MariaNador, Fabiana GabrielaRuiz Molina, DanielMesoporous SilicaNanoparticlesPolydopamineGatekeepinghttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; EspañaFil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; EspañaFil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; EspañaAmerican Chemical Society2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56442Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-76691944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.7b08584info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.7b08584info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:43Zoai:ri.conicet.gov.ar:11336/56442instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:43.955CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
title |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
spellingShingle |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles Moreno Villaecija, Miguel Angel Mesoporous Silica Nanoparticles Polydopamine Gatekeeping |
title_short |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
title_full |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
title_fullStr |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
title_full_unstemmed |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
title_sort |
Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles |
dc.creator.none.fl_str_mv |
Moreno Villaecija, Miguel Angel Sedó Vegara, Josep Guisasola Cal, Eduardo Baeza, Alejandro Vallet Regí, Maria Nador, Fabiana Gabriela Ruiz Molina, Daniel |
author |
Moreno Villaecija, Miguel Angel |
author_facet |
Moreno Villaecija, Miguel Angel Sedó Vegara, Josep Guisasola Cal, Eduardo Baeza, Alejandro Vallet Regí, Maria Nador, Fabiana Gabriela Ruiz Molina, Daniel |
author_role |
author |
author2 |
Sedó Vegara, Josep Guisasola Cal, Eduardo Baeza, Alejandro Vallet Regí, Maria Nador, Fabiana Gabriela Ruiz Molina, Daniel |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Mesoporous Silica Nanoparticles Polydopamine Gatekeeping |
topic |
Mesoporous Silica Nanoparticles Polydopamine Gatekeeping |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time. Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; España Fil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; España Fil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España Fil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España Fil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; España |
description |
We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/56442 Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-7669 1944-8244 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/56442 |
identifier_str_mv |
Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-7669 1944-8244 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.7b08584 info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.7b08584 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268937028370432 |
score |
13.13397 |