Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles

Autores
Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; Nador, Fabiana Gabriela; Ruiz Molina, Daniel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; España
Fil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; España
Fil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; España
Materia
Mesoporous Silica
Nanoparticles
Polydopamine
Gatekeeping
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56442
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/56442
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica NanoparticlesMoreno Villaecija, Miguel AngelSedó Vegara, JosepGuisasola Cal, EduardoBaeza, AlejandroVallet Regí, MariaNador, Fabiana GabrielaRuiz Molina, DanielMesoporous SilicaNanoparticlesPolydopamineGatekeepinghttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; EspañaFil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; EspañaFil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; EspañaFil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; EspañaAmerican Chemical Society2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56442Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-76691944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.7b08584info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.7b08584info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:07Zoai:ri.conicet.gov.ar:11336/56442instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:07.437CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
spellingShingle Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
Moreno Villaecija, Miguel Angel
Mesoporous Silica
Nanoparticles
Polydopamine
Gatekeeping
title_short Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_full Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_fullStr Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_full_unstemmed Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_sort Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
dc.creator.none.fl_str_mv Moreno Villaecija, Miguel Angel
Sedó Vegara, Josep
Guisasola Cal, Eduardo
Baeza, Alejandro
Vallet Regí, Maria
Nador, Fabiana Gabriela
Ruiz Molina, Daniel
author Moreno Villaecija, Miguel Angel
author_facet Moreno Villaecija, Miguel Angel
Sedó Vegara, Josep
Guisasola Cal, Eduardo
Baeza, Alejandro
Vallet Regí, Maria
Nador, Fabiana Gabriela
Ruiz Molina, Daniel
author_role author
author2 Sedó Vegara, Josep
Guisasola Cal, Eduardo
Baeza, Alejandro
Vallet Regí, Maria
Nador, Fabiana Gabriela
Ruiz Molina, Daniel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Mesoporous Silica
Nanoparticles
Polydopamine
Gatekeeping
topic Mesoporous Silica
Nanoparticles
Polydopamine
Gatekeeping
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
Fil: Moreno Villaecija, Miguel Angel. Consejo Superior de Investigaciones Científicas; España
Fil: Sedó Vegara, Josep. Consejo Superior de Investigaciones Científicas; España
Fil: Guisasola Cal, Eduardo. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Baeza, Alejandro. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Vallet Regí, Maria. Universidad Complutense de Madrid; España. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Ruiz Molina, Daniel. Consejo Superior de Investigaciones Científicas; España
description We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56442
Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-7669
1944-8244
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56442
identifier_str_mv Moreno Villaecija, Miguel Angel; Sedó Vegara, Josep; Guisasola Cal, Eduardo; Baeza, Alejandro; Vallet Regí, Maria; et al.; Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles; American Chemical Society; ACS Applied Materials & Interfaces; 10; 9; 3-2018; 7661-7669
1944-8244
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.7b08584
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.7b08584
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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