Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes

Autores
Udabe, Jakes; Tiwari, Neha; Picco, Agustin Silvio; Huck Iriart, Cristián; Escudero, Carlos; Calderón, Marcelo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanoparticles (NPs) with functional cores are gaining research interest due to their advanced architecture. However, exposed reactive groups on NP surfaces can lead to material side reactions and biomedical tissue damage. NPs with multi-hierarchical morphologies can be synthesized by various methods; however, controlling the size and position of the functional groups using conventional and scalable methods is still a challenge. This study explores emulsion-based polymerization methods for producing multi-hierarchical NPs with varying sizes and compositions. We compared micro-, macro-, and semi-batch emulsion polymerization using 2-hydroxyethyl methacrylate (HEMA) and pentafluorophenyl methacrylate (PFMA) as co-monomers. The components present in PFMA can be substituted and are used for post-synthetic functionalization. The results suggest that the architecture of the synthesized NPs is multi-hierarchical, with the substitutable pentafluorophenyl units surrounded by HEMA monomers. Additionally, we evaluated the NPs' ability to enhance dermal drug penetration using nile red as a hydrophobic drug model. Significant variations in skin permeation enhancement properties were observed among the NPs, underscoring the impact of the synthesis method on nanocarriers' drug delivery performance.
Fil: Udabe, Jakes. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; España
Fil: Tiwari, Neha. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; España
Fil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Tecnologías Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologías Emergentes y Ciencias Aplicadas; Argentina. ALBA Synchrotron Light Source; España
Fil: Escudero, Carlos. ALBA Synchrotron Light Source; España
Fil: Calderón, Marcelo. Universidad del País Vasco; España. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco. Polymat; España
Materia
CORE-SHELL
EMULSION POLYMERIZATION
NANOPARTICLE
SKIN PENETRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229126
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/229126
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processesUdabe, JakesTiwari, NehaPicco, Agustin SilvioHuck Iriart, CristiánEscudero, CarlosCalderón, MarceloCORE-SHELLEMULSION POLYMERIZATIONNANOPARTICLESKIN PENETRATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nanoparticles (NPs) with functional cores are gaining research interest due to their advanced architecture. However, exposed reactive groups on NP surfaces can lead to material side reactions and biomedical tissue damage. NPs with multi-hierarchical morphologies can be synthesized by various methods; however, controlling the size and position of the functional groups using conventional and scalable methods is still a challenge. This study explores emulsion-based polymerization methods for producing multi-hierarchical NPs with varying sizes and compositions. We compared micro-, macro-, and semi-batch emulsion polymerization using 2-hydroxyethyl methacrylate (HEMA) and pentafluorophenyl methacrylate (PFMA) as co-monomers. The components present in PFMA can be substituted and are used for post-synthetic functionalization. The results suggest that the architecture of the synthesized NPs is multi-hierarchical, with the substitutable pentafluorophenyl units surrounded by HEMA monomers. Additionally, we evaluated the NPs' ability to enhance dermal drug penetration using nile red as a hydrophobic drug model. Significant variations in skin permeation enhancement properties were observed among the NPs, underscoring the impact of the synthesis method on nanocarriers' drug delivery performance.Fil: Udabe, Jakes. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; EspañaFil: Tiwari, Neha. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; EspañaFil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Tecnologías Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologías Emergentes y Ciencias Aplicadas; Argentina. ALBA Synchrotron Light Source; EspañaFil: Escudero, Carlos. ALBA Synchrotron Light Source; EspañaFil: Calderón, Marcelo. Universidad del País Vasco; España. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco. Polymat; EspañaPergamon-Elsevier Science Ltd2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229126Udabe, Jakes; Tiwari, Neha; Picco, Agustin Silvio; Huck Iriart, Cristián; Escudero, Carlos; et al.; Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes; Pergamon-Elsevier Science Ltd; European Polymer Journal; 201; 112566; 12-2023; 1-100014-3057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2023.112566info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014305723007498info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:30Zoai:ri.conicet.gov.ar:11336/229126instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:31.077CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
title Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
spellingShingle Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
Udabe, Jakes
CORE-SHELL
EMULSION POLYMERIZATION
NANOPARTICLE
SKIN PENETRATION
title_short Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
title_full Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
title_fullStr Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
title_full_unstemmed Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
title_sort Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes
dc.creator.none.fl_str_mv Udabe, Jakes
Tiwari, Neha
Picco, Agustin Silvio
Huck Iriart, Cristián
Escudero, Carlos
Calderón, Marcelo
author Udabe, Jakes
author_facet Udabe, Jakes
Tiwari, Neha
Picco, Agustin Silvio
Huck Iriart, Cristián
Escudero, Carlos
Calderón, Marcelo
author_role author
author2 Tiwari, Neha
Picco, Agustin Silvio
Huck Iriart, Cristián
Escudero, Carlos
Calderón, Marcelo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CORE-SHELL
EMULSION POLYMERIZATION
NANOPARTICLE
SKIN PENETRATION
topic CORE-SHELL
EMULSION POLYMERIZATION
NANOPARTICLE
SKIN PENETRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nanoparticles (NPs) with functional cores are gaining research interest due to their advanced architecture. However, exposed reactive groups on NP surfaces can lead to material side reactions and biomedical tissue damage. NPs with multi-hierarchical morphologies can be synthesized by various methods; however, controlling the size and position of the functional groups using conventional and scalable methods is still a challenge. This study explores emulsion-based polymerization methods for producing multi-hierarchical NPs with varying sizes and compositions. We compared micro-, macro-, and semi-batch emulsion polymerization using 2-hydroxyethyl methacrylate (HEMA) and pentafluorophenyl methacrylate (PFMA) as co-monomers. The components present in PFMA can be substituted and are used for post-synthetic functionalization. The results suggest that the architecture of the synthesized NPs is multi-hierarchical, with the substitutable pentafluorophenyl units surrounded by HEMA monomers. Additionally, we evaluated the NPs' ability to enhance dermal drug penetration using nile red as a hydrophobic drug model. Significant variations in skin permeation enhancement properties were observed among the NPs, underscoring the impact of the synthesis method on nanocarriers' drug delivery performance.
Fil: Udabe, Jakes. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; España
Fil: Tiwari, Neha. Universidad del País Vasco; España. Universidad del País Vasco. Polymat; España
Fil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Tecnologías Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologías Emergentes y Ciencias Aplicadas; Argentina. ALBA Synchrotron Light Source; España
Fil: Escudero, Carlos. ALBA Synchrotron Light Source; España
Fil: Calderón, Marcelo. Universidad del País Vasco; España. Ikerbasque, Basque Foundation For Science; España. Universidad del País Vasco. Polymat; España
description Nanoparticles (NPs) with functional cores are gaining research interest due to their advanced architecture. However, exposed reactive groups on NP surfaces can lead to material side reactions and biomedical tissue damage. NPs with multi-hierarchical morphologies can be synthesized by various methods; however, controlling the size and position of the functional groups using conventional and scalable methods is still a challenge. This study explores emulsion-based polymerization methods for producing multi-hierarchical NPs with varying sizes and compositions. We compared micro-, macro-, and semi-batch emulsion polymerization using 2-hydroxyethyl methacrylate (HEMA) and pentafluorophenyl methacrylate (PFMA) as co-monomers. The components present in PFMA can be substituted and are used for post-synthetic functionalization. The results suggest that the architecture of the synthesized NPs is multi-hierarchical, with the substitutable pentafluorophenyl units surrounded by HEMA monomers. Additionally, we evaluated the NPs' ability to enhance dermal drug penetration using nile red as a hydrophobic drug model. Significant variations in skin permeation enhancement properties were observed among the NPs, underscoring the impact of the synthesis method on nanocarriers' drug delivery performance.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229126
Udabe, Jakes; Tiwari, Neha; Picco, Agustin Silvio; Huck Iriart, Cristián; Escudero, Carlos; et al.; Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes; Pergamon-Elsevier Science Ltd; European Polymer Journal; 201; 112566; 12-2023; 1-10
0014-3057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229126
identifier_str_mv Udabe, Jakes; Tiwari, Neha; Picco, Agustin Silvio; Huck Iriart, Cristián; Escudero, Carlos; et al.; Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes; Pergamon-Elsevier Science Ltd; European Polymer Journal; 201; 112566; 12-2023; 1-10
0014-3057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2023.112566
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014305723007498
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269584661413888
score 13.13397

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