Targeting late ICaL to close the window to ventricular arrhythmias

Autores
Gonano, Luis Alberto; Mattiazzi, Ramona Alicia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Triggered arrhythmias originate from aberrant cell membrane depolarizations that occur during or after completion of the cardiac action potential (AP). Although the phenomenon was recognized early and associated with cardiac arrhythmias in recordings relying on monophasic APs (Segers, 1941; Bozler, 1943), the concept of triggered activity was coined several decades later by Paul Cranefield (Cranefield, 1975) who, incidentally, served as editor-in-chief of this journal for more than 25 yr. This new term aimed to differentiate the slow membrane depolarization that depends on a previous AP (triggered activity) from automaticity, a slow membrane depolarization with different properties like the rhythmicity and spontaneity and independence on a preceding AP. Cranefield also originated the term “afterdepolarizations” for this triggered activity and described what are now traditionally known as early afterdepolarizations (EADs) “…that appears before the membrane potential has returned to the level it had at the beginning of the upstroke of the action potential,” and delayed afterdepolarizations (DADs), which occur “…after repolarization is complete i.e., after the membrane potential has returned to the level seen before the action potential” (Cranefield, 1975, 1977).
Fil: Gonano, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Materia
ICA L
ARRHYTHMIA
ROSCOVITINE
HEART
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181299
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Targeting late ICaL to close the window to ventricular arrhythmiasGonano, Luis AlbertoMattiazzi, Ramona AliciaICA LARRHYTHMIAROSCOVITINEHEARThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Triggered arrhythmias originate from aberrant cell membrane depolarizations that occur during or after completion of the cardiac action potential (AP). Although the phenomenon was recognized early and associated with cardiac arrhythmias in recordings relying on monophasic APs (Segers, 1941; Bozler, 1943), the concept of triggered activity was coined several decades later by Paul Cranefield (Cranefield, 1975) who, incidentally, served as editor-in-chief of this journal for more than 25 yr. This new term aimed to differentiate the slow membrane depolarization that depends on a previous AP (triggered activity) from automaticity, a slow membrane depolarization with different properties like the rhythmicity and spontaneity and independence on a preceding AP. Cranefield also originated the term “afterdepolarizations” for this triggered activity and described what are now traditionally known as early afterdepolarizations (EADs) “…that appears before the membrane potential has returned to the level it had at the beginning of the upstroke of the action potential,” and delayed afterdepolarizations (DADs), which occur “…after repolarization is complete i.e., after the membrane potential has returned to the level seen before the action potential” (Cranefield, 1975, 1977).Fil: Gonano, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaRockefeller University Press2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181299Gonano, Luis Alberto; Mattiazzi, Ramona Alicia; Targeting late ICaL to close the window to ventricular arrhythmias; Rockefeller University Press; Journal Of General Physiology; 153; 12; 10-2021; 1-40022-1295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://rupress.org/jgp/article/153/12/e202113009/212726/Targeting-late-ICaL-to-close-the-window-toinfo:eu-repo/semantics/altIdentifier/doi/10.1085/jgp.202113009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:20:45Zoai:ri.conicet.gov.ar:11336/181299instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:20:45.553CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Targeting late ICaL to close the window to ventricular arrhythmias
title Targeting late ICaL to close the window to ventricular arrhythmias
spellingShingle Targeting late ICaL to close the window to ventricular arrhythmias
Gonano, Luis Alberto
ICA L
ARRHYTHMIA
ROSCOVITINE
HEART
title_short Targeting late ICaL to close the window to ventricular arrhythmias
title_full Targeting late ICaL to close the window to ventricular arrhythmias
title_fullStr Targeting late ICaL to close the window to ventricular arrhythmias
title_full_unstemmed Targeting late ICaL to close the window to ventricular arrhythmias
title_sort Targeting late ICaL to close the window to ventricular arrhythmias
dc.creator.none.fl_str_mv Gonano, Luis Alberto
Mattiazzi, Ramona Alicia
author Gonano, Luis Alberto
author_facet Gonano, Luis Alberto
Mattiazzi, Ramona Alicia
author_role author
author2 Mattiazzi, Ramona Alicia
author2_role author
dc.subject.none.fl_str_mv ICA L
ARRHYTHMIA
ROSCOVITINE
HEART
topic ICA L
ARRHYTHMIA
ROSCOVITINE
HEART
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Triggered arrhythmias originate from aberrant cell membrane depolarizations that occur during or after completion of the cardiac action potential (AP). Although the phenomenon was recognized early and associated with cardiac arrhythmias in recordings relying on monophasic APs (Segers, 1941; Bozler, 1943), the concept of triggered activity was coined several decades later by Paul Cranefield (Cranefield, 1975) who, incidentally, served as editor-in-chief of this journal for more than 25 yr. This new term aimed to differentiate the slow membrane depolarization that depends on a previous AP (triggered activity) from automaticity, a slow membrane depolarization with different properties like the rhythmicity and spontaneity and independence on a preceding AP. Cranefield also originated the term “afterdepolarizations” for this triggered activity and described what are now traditionally known as early afterdepolarizations (EADs) “…that appears before the membrane potential has returned to the level it had at the beginning of the upstroke of the action potential,” and delayed afterdepolarizations (DADs), which occur “…after repolarization is complete i.e., after the membrane potential has returned to the level seen before the action potential” (Cranefield, 1975, 1977).
Fil: Gonano, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
description Triggered arrhythmias originate from aberrant cell membrane depolarizations that occur during or after completion of the cardiac action potential (AP). Although the phenomenon was recognized early and associated with cardiac arrhythmias in recordings relying on monophasic APs (Segers, 1941; Bozler, 1943), the concept of triggered activity was coined several decades later by Paul Cranefield (Cranefield, 1975) who, incidentally, served as editor-in-chief of this journal for more than 25 yr. This new term aimed to differentiate the slow membrane depolarization that depends on a previous AP (triggered activity) from automaticity, a slow membrane depolarization with different properties like the rhythmicity and spontaneity and independence on a preceding AP. Cranefield also originated the term “afterdepolarizations” for this triggered activity and described what are now traditionally known as early afterdepolarizations (EADs) “…that appears before the membrane potential has returned to the level it had at the beginning of the upstroke of the action potential,” and delayed afterdepolarizations (DADs), which occur “…after repolarization is complete i.e., after the membrane potential has returned to the level seen before the action potential” (Cranefield, 1975, 1977).
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181299
Gonano, Luis Alberto; Mattiazzi, Ramona Alicia; Targeting late ICaL to close the window to ventricular arrhythmias; Rockefeller University Press; Journal Of General Physiology; 153; 12; 10-2021; 1-4
0022-1295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181299
identifier_str_mv Gonano, Luis Alberto; Mattiazzi, Ramona Alicia; Targeting late ICaL to close the window to ventricular arrhythmias; Rockefeller University Press; Journal Of General Physiology; 153; 12; 10-2021; 1-4
0022-1295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://rupress.org/jgp/article/153/12/e202113009/212726/Targeting-late-ICaL-to-close-the-window-to
info:eu-repo/semantics/altIdentifier/doi/10.1085/jgp.202113009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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