Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
- Autores
- Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil - Materia
-
Central Nervous System
Electron Microscopy
Goats
Lectin Histochemistry
Lysosomes
Pancreas
Poisonous Plants
Sida Carpinifolia
Storage Disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53451
Ver los metadatos del registro completo
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Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in GoatsDriemeier, D.Colodel, E. M.Gimeno, Eduardo JuanBarros, S. S.Central Nervous SystemElectron MicroscopyGoatsLectin HistochemistryLysosomesPancreasPoisonous PlantsSida CarpinifoliaStorage Diseasehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; BrasilFil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barros, S. S.. Universidade Federal de Pelotas; BrasilAmerican College of Veterinary Pathologists2000-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53451Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-1590300-9858CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1354/vp.37-2-153info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1354/vp.37-2-153info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:40Zoai:ri.conicet.gov.ar:11336/53451instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:40.44CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
title |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
spellingShingle |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats Driemeier, D. Central Nervous System Electron Microscopy Goats Lectin Histochemistry Lysosomes Pancreas Poisonous Plants Sida Carpinifolia Storage Disease |
title_short |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
title_full |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
title_fullStr |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
title_full_unstemmed |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
title_sort |
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats |
dc.creator.none.fl_str_mv |
Driemeier, D. Colodel, E. M. Gimeno, Eduardo Juan Barros, S. S. |
author |
Driemeier, D. |
author_facet |
Driemeier, D. Colodel, E. M. Gimeno, Eduardo Juan Barros, S. S. |
author_role |
author |
author2 |
Colodel, E. M. Gimeno, Eduardo Juan Barros, S. S. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Central Nervous System Electron Microscopy Goats Lectin Histochemistry Lysosomes Pancreas Poisonous Plants Sida Carpinifolia Storage Disease |
topic |
Central Nervous System Electron Microscopy Goats Lectin Histochemistry Lysosomes Pancreas Poisonous Plants Sida Carpinifolia Storage Disease |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis. Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil |
description |
A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53451 Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-159 0300-9858 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/53451 |
identifier_str_mv |
Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-159 0300-9858 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1354/vp.37-2-153 info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1354/vp.37-2-153 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American College of Veterinary Pathologists |
publisher.none.fl_str_mv |
American College of Veterinary Pathologists |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614255885680640 |
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13.070432 |