Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats

Autores
Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
Materia
Central Nervous System
Electron Microscopy
Goats
Lectin Histochemistry
Lysosomes
Pancreas
Poisonous Plants
Sida Carpinifolia
Storage Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53451
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/53451
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in GoatsDriemeier, D.Colodel, E. M.Gimeno, Eduardo JuanBarros, S. S.Central Nervous SystemElectron MicroscopyGoatsLectin HistochemistryLysosomesPancreasPoisonous PlantsSida CarpinifoliaStorage Diseasehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; BrasilFil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barros, S. S.. Universidade Federal de Pelotas; BrasilAmerican College of Veterinary Pathologists2000-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53451Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-1590300-9858CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1354/vp.37-2-153info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1354/vp.37-2-153info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:58:21Zoai:ri.conicet.gov.ar:11336/53451instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:58:21.626CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
title Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
spellingShingle Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
Driemeier, D.
Central Nervous System
Electron Microscopy
Goats
Lectin Histochemistry
Lysosomes
Pancreas
Poisonous Plants
Sida Carpinifolia
Storage Disease
title_short Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
title_full Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
title_fullStr Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
title_full_unstemmed Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
title_sort Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
dc.creator.none.fl_str_mv Driemeier, D.
Colodel, E. M.
Gimeno, Eduardo Juan
Barros, S. S.
author Driemeier, D.
author_facet Driemeier, D.
Colodel, E. M.
Gimeno, Eduardo Juan
Barros, S. S.
author_role author
author2 Colodel, E. M.
Gimeno, Eduardo Juan
Barros, S. S.
author2_role author
author
author
dc.subject.none.fl_str_mv Central Nervous System
Electron Microscopy
Goats
Lectin Histochemistry
Lysosomes
Pancreas
Poisonous Plants
Sida Carpinifolia
Storage Disease
topic Central Nervous System
Electron Microscopy
Goats
Lectin Histochemistry
Lysosomes
Pancreas
Poisonous Plants
Sida Carpinifolia
Storage Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
description A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.
publishDate 2000
dc.date.none.fl_str_mv 2000-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53451
Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-159
0300-9858
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53451
identifier_str_mv Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-159
0300-9858
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1354/vp.37-2-153
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1354/vp.37-2-153
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American College of Veterinary Pathologists
publisher.none.fl_str_mv American College of Veterinary Pathologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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