Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome

Autores
Jacome Sosa, M. Miriam; Borthwick, Faye; Mangat, Rabban; Uwiera, Richard; Reaney, Martin J.; Shen, Jianheng; Quiroga, Ariel Dario; Jacobs, René L.; Lehner, Richard; Proctor, Spencer D.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trans11-18:1 (vaccenic acid, VA) is one of the most predominant naturally occurring trans fats in our food chain and has recently been shown to exert hypolipidemic effects in animal models. In this study, we reveal new mechanism(s) by which VA can alter body fat distribution, energy utilization and dysfunctional lipid metabolism in an animal model of obesity displaying features of the metabolic syndrome (MetS). Obese JCR:LA-cp rats were assigned to a control diet that included dairy-derived fat or the control diet supplemented with 1% VA. VA reduced total body fat (-6%), stimulated adipose tissue redistribution [reduced mesenteric fat (-17%) while increasing inguinal fat mass (29%)] and decreased adipocyte size (-44%) versus control rats. VA supplementation also increased metabolic rate (7%) concomitantly with an increased preference for whole-body glucose utilization for oxidation and increased insulin sensitivity [lower HOMA-IR (-59%)]. Further, VA decreased nonalcoholic fatty liver disease activity scores (-34%) and reduced hepatic (-27%) and intestinal (-39%) triglyceride secretion relative to control diet, while exerting differential transcriptional regulation of SREBP1 and FAS amongst other key genes in the liver and the intestine. Adding VA to dairy fat alleviates features of MetS potentially by remodeling adipose tissue and attenuating ectopic lipid accumulation in a rat model of obesity and MetS. Increasing VA content in the diet (naturally or by fortification) may be a useful approach to maximize the health value of dairy-derived fats.
Fil: Jacome Sosa, M. Miriam. University of Alberta; Canadá
Fil: Borthwick, Faye. University of Alberta; Canadá
Fil: Mangat, Rabban. University of Alberta; Canadá
Fil: Uwiera, Richard. University of Alberta; Canadá
Fil: Reaney, Martin J.. University of Saskatchewan; Canadá
Fil: Shen, Jianheng. University of Saskatchewan; Canadá
Fil: Quiroga, Ariel Dario. University of Alberta; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Jacobs, René L.. University of Alberta; Canadá
Fil: Lehner, Richard. University of Alberta; Canadá
Fil: Proctor, Spencer D.. University of Alberta; Canadá
Materia
ENERGY EXPENDITURE
FAT REDISTRIBUTION
INSULIN RESISTANCE
SATURATED FAT
TRIGLYCERIDE SECRETION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6034
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6034
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndromeJacome Sosa, M. MiriamBorthwick, FayeMangat, RabbanUwiera, RichardReaney, Martin J.Shen, JianhengQuiroga, Ariel DarioJacobs, René L.Lehner, RichardProctor, Spencer D.ENERGY EXPENDITUREFAT REDISTRIBUTIONINSULIN RESISTANCESATURATED FATTRIGLYCERIDE SECRETIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Trans11-18:1 (vaccenic acid, VA) is one of the most predominant naturally occurring trans fats in our food chain and has recently been shown to exert hypolipidemic effects in animal models. In this study, we reveal new mechanism(s) by which VA can alter body fat distribution, energy utilization and dysfunctional lipid metabolism in an animal model of obesity displaying features of the metabolic syndrome (MetS). Obese JCR:LA-cp rats were assigned to a control diet that included dairy-derived fat or the control diet supplemented with 1% VA. VA reduced total body fat (-6%), stimulated adipose tissue redistribution [reduced mesenteric fat (-17%) while increasing inguinal fat mass (29%)] and decreased adipocyte size (-44%) versus control rats. VA supplementation also increased metabolic rate (7%) concomitantly with an increased preference for whole-body glucose utilization for oxidation and increased insulin sensitivity [lower HOMA-IR (-59%)]. Further, VA decreased nonalcoholic fatty liver disease activity scores (-34%) and reduced hepatic (-27%) and intestinal (-39%) triglyceride secretion relative to control diet, while exerting differential transcriptional regulation of SREBP1 and FAS amongst other key genes in the liver and the intestine. Adding VA to dairy fat alleviates features of MetS potentially by remodeling adipose tissue and attenuating ectopic lipid accumulation in a rat model of obesity and MetS. Increasing VA content in the diet (naturally or by fortification) may be a useful approach to maximize the health value of dairy-derived fats.Fil: Jacome Sosa, M. Miriam. University of Alberta; CanadáFil: Borthwick, Faye. University of Alberta; CanadáFil: Mangat, Rabban. University of Alberta; CanadáFil: Uwiera, Richard. University of Alberta; CanadáFil: Reaney, Martin J.. University of Saskatchewan; CanadáFil: Shen, Jianheng. University of Saskatchewan; CanadáFil: Quiroga, Ariel Dario. University of Alberta; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Jacobs, René L.. University of Alberta; CanadáFil: Lehner, Richard. University of Alberta; CanadáFil: Proctor, Spencer D.. University of Alberta; CanadáElsevier Science Inc.2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6034Jacome Sosa, M. Miriam; Borthwick, Faye; Mangat, Rabban; Uwiera, Richard; Reaney, Martin J.; et al.; Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 25; 7; 7-2014; 692-7010955-2863enghttp://www.sciencedirect.com/science/article/pii/S0955286316000048info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0955286314000527info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2014.02.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:38:14Zoai:ri.conicet.gov.ar:11336/6034instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:38:15.075CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
title Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
spellingShingle Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
Jacome Sosa, M. Miriam
ENERGY EXPENDITURE
FAT REDISTRIBUTION
INSULIN RESISTANCE
SATURATED FAT
TRIGLYCERIDE SECRETION
title_short Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
title_full Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
title_fullStr Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
title_full_unstemmed Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
title_sort Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome
dc.creator.none.fl_str_mv Jacome Sosa, M. Miriam
Borthwick, Faye
Mangat, Rabban
Uwiera, Richard
Reaney, Martin J.
Shen, Jianheng
Quiroga, Ariel Dario
Jacobs, René L.
Lehner, Richard
Proctor, Spencer D.
author Jacome Sosa, M. Miriam
author_facet Jacome Sosa, M. Miriam
Borthwick, Faye
Mangat, Rabban
Uwiera, Richard
Reaney, Martin J.
Shen, Jianheng
Quiroga, Ariel Dario
Jacobs, René L.
Lehner, Richard
Proctor, Spencer D.
author_role author
author2 Borthwick, Faye
Mangat, Rabban
Uwiera, Richard
Reaney, Martin J.
Shen, Jianheng
Quiroga, Ariel Dario
Jacobs, René L.
Lehner, Richard
Proctor, Spencer D.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENERGY EXPENDITURE
FAT REDISTRIBUTION
INSULIN RESISTANCE
SATURATED FAT
TRIGLYCERIDE SECRETION
topic ENERGY EXPENDITURE
FAT REDISTRIBUTION
INSULIN RESISTANCE
SATURATED FAT
TRIGLYCERIDE SECRETION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trans11-18:1 (vaccenic acid, VA) is one of the most predominant naturally occurring trans fats in our food chain and has recently been shown to exert hypolipidemic effects in animal models. In this study, we reveal new mechanism(s) by which VA can alter body fat distribution, energy utilization and dysfunctional lipid metabolism in an animal model of obesity displaying features of the metabolic syndrome (MetS). Obese JCR:LA-cp rats were assigned to a control diet that included dairy-derived fat or the control diet supplemented with 1% VA. VA reduced total body fat (-6%), stimulated adipose tissue redistribution [reduced mesenteric fat (-17%) while increasing inguinal fat mass (29%)] and decreased adipocyte size (-44%) versus control rats. VA supplementation also increased metabolic rate (7%) concomitantly with an increased preference for whole-body glucose utilization for oxidation and increased insulin sensitivity [lower HOMA-IR (-59%)]. Further, VA decreased nonalcoholic fatty liver disease activity scores (-34%) and reduced hepatic (-27%) and intestinal (-39%) triglyceride secretion relative to control diet, while exerting differential transcriptional regulation of SREBP1 and FAS amongst other key genes in the liver and the intestine. Adding VA to dairy fat alleviates features of MetS potentially by remodeling adipose tissue and attenuating ectopic lipid accumulation in a rat model of obesity and MetS. Increasing VA content in the diet (naturally or by fortification) may be a useful approach to maximize the health value of dairy-derived fats.
Fil: Jacome Sosa, M. Miriam. University of Alberta; Canadá
Fil: Borthwick, Faye. University of Alberta; Canadá
Fil: Mangat, Rabban. University of Alberta; Canadá
Fil: Uwiera, Richard. University of Alberta; Canadá
Fil: Reaney, Martin J.. University of Saskatchewan; Canadá
Fil: Shen, Jianheng. University of Saskatchewan; Canadá
Fil: Quiroga, Ariel Dario. University of Alberta; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Jacobs, René L.. University of Alberta; Canadá
Fil: Lehner, Richard. University of Alberta; Canadá
Fil: Proctor, Spencer D.. University of Alberta; Canadá
description Trans11-18:1 (vaccenic acid, VA) is one of the most predominant naturally occurring trans fats in our food chain and has recently been shown to exert hypolipidemic effects in animal models. In this study, we reveal new mechanism(s) by which VA can alter body fat distribution, energy utilization and dysfunctional lipid metabolism in an animal model of obesity displaying features of the metabolic syndrome (MetS). Obese JCR:LA-cp rats were assigned to a control diet that included dairy-derived fat or the control diet supplemented with 1% VA. VA reduced total body fat (-6%), stimulated adipose tissue redistribution [reduced mesenteric fat (-17%) while increasing inguinal fat mass (29%)] and decreased adipocyte size (-44%) versus control rats. VA supplementation also increased metabolic rate (7%) concomitantly with an increased preference for whole-body glucose utilization for oxidation and increased insulin sensitivity [lower HOMA-IR (-59%)]. Further, VA decreased nonalcoholic fatty liver disease activity scores (-34%) and reduced hepatic (-27%) and intestinal (-39%) triglyceride secretion relative to control diet, while exerting differential transcriptional regulation of SREBP1 and FAS amongst other key genes in the liver and the intestine. Adding VA to dairy fat alleviates features of MetS potentially by remodeling adipose tissue and attenuating ectopic lipid accumulation in a rat model of obesity and MetS. Increasing VA content in the diet (naturally or by fortification) may be a useful approach to maximize the health value of dairy-derived fats.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6034
Jacome Sosa, M. Miriam; Borthwick, Faye; Mangat, Rabban; Uwiera, Richard; Reaney, Martin J.; et al.; Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 25; 7; 7-2014; 692-701
0955-2863
url http://hdl.handle.net/11336/6034
identifier_str_mv Jacome Sosa, M. Miriam; Borthwick, Faye; Mangat, Rabban; Uwiera, Richard; Reaney, Martin J.; et al.; Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 25; 7; 7-2014; 692-701
0955-2863
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.sciencedirect.com/science/article/pii/S0955286316000048
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0955286314000527
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2014.02.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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